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Preclinical studies suggest that taurine may exert neuroprotective effects. However, its relevance to dementia risk in human populations remains unclear. We investigated the associations between mid-life dietary taurine intake, circulating taurine concentrations, and the risk of late-life all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD) in a large prospective cohort. This

Targeted radionuclide therapy is an emerging potent therapeutic strategy in oncology. The cell surface antigen CD44v6 is a potential pan-cancer target for radionuclide therapy. This study aimed to evaluate the therapeutic efficacy, biodistribution, dosimetry, and safety profile of AKIR001, an antibody targeting CD44v6 labeled with 177Lu. Methods: The biodistribution and preclinical dosimetry of [1

In recent decades, with the advancement of technologies facilitating reproduction, parents have been able to make decisions regarding their childrens’ reproductive potential: to preserve their fertility when threatened by genetic conditions or medical treatment; to use their gametes or embryos to make grandchildren; or even to collect their gametes posthumously and then use them to make grandchild

Peatland trees are valuable archives of paleoclimatic information; however, gaps persist in understanding the relationships between tree growth, peatland hydrology, and hydroclimate variables. While previous research in peatlands has mainly focused on tree-ring widths (TRW), yielding inconclusive results, the potential of stable carbon (δ13C) and oxygen (δ18O) isotopes in tree rings remains unexpl

STUDY QUESTION What are the perspectives of oocyte and sperm donors 14-17 years post-donation on the release of their identity and potential contact with donor-conceived offspring (DCO)? SUMMARY ANSWER Most oocyte and sperm donors wanted to be notified about future releases of their identity and were positive towards contact with DCO, but more than half expressed a need for support in relation to

Dust is essential to the evolution of galaxies and drives the formation of planetary systems. The challenge of inferring the origin of different pre-solar dust grains from meteoritic samples motivates forward modelling to understand the contributions of low- and high-mass stars to dust in our Solar system. In this work we follow the evolution of dust with tracer particles within a hydrodynamical s

Background: In patients with rectal cancer, when it is not possible to restore bowel continuity with an anastomosis, the optimal surgical method is still a matter of debate. The aim of this trial was to determine 30-day postoperative surgical complication rates after Hartmann’s procedure (HP) versus intersphincteric abdominoperineal excision (iAPE) in patients with rectal cancer who were not suita

We investigate the young stellar cluster population of M51 and how it is affected by encounters with giant molecular clouds (GMCs). We combine a galactic model with N-body simulations of 5000 unique clusters in the mass range [600-24000] M⊙. We simulate each cluster twice: with (CR) and without (CN) tidal perturbations from the GMCs. We are able to reproduce the majority of the observed mass- and

The end of what the GDR called “real existierender Sozialismus” in Europe at the beginning of the 1990s dramatically changed the geopolitical situation in Central and Eastern Europe. Five states ceased to exist, whereas 22 new states have been recognized, accompanied by a host of internationally unrecognized states. Nearly half a century of relative stability in Europe was replaced by volatility a

Adaptive dynamical networks (ADNs) describe systems in which the states of the network nodes and the network structure itself co-evolve over time. This interplay of two coupled dynamical processes underlies a wide range of natural and technological phenomena, such as neural plasticity, learning, and opinion formation. The inherently co-evolutionary nature of ADNs poses significant challenges to ma

Allergic asthma is characterized by Type 2 inflammation and eosinophilia. Tartrate-resistant acid phosphatase 5 (TRAP5; also referred to as acid phosphatase 5 [ACP5]) is a metallophosphatase expressed by alveolar macrophages that dephosphorylates osteopontin, a phosphoglycoprotein with increased expression in asthma. To investigate the role of TRAP5 during asthma, we used a murine model of ovalbum

Objective: To investigate the development of sexual activity, sexual function, and body image in women with primary vulvar cancer from the time of diagnosis to 24 months after the end of treatment. Methods: This nationwide prospective cohort study assessed health-related quality of life in women with newly diagnosed vulvar cancer using validated patient-reported outcome measures (EORTC-QLQ-VU34 [E

OBJECTIVE: To estimate the prevalence and predictors of sustained remission (SR) in patients with psoriatic arthritis (PsA) receiving biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in Sweden. METHODS: All patients with PsA initiating b/tsDMARDs and who were registered in the national Swedish Rheumatology Quality Register (SRQ) from April 1999 to December 2019 wer

Using an Earth-abundant transition metal to mediate formation and splitting of C-C σ-bonds, in response to electrical stimuli, constitutes a promising strategy to construct complex organic skeletons. Here, we showcase how [nBu4N][N3] reacts with an isocyanide adduct of a tetrahedral and high-spin TiII complex, [(TptBu,Me)TiCl] (1), to enact N-atom transfer, C-N bond formation, and C-C coupling, to

ObjectivesThis nested case–control study aimed to investigate the relationship between components of the Swedish food-based dietary guidelines (SDG) from 2015 and the risk of developing rheumatoid arthritis (RA).MethodsData were obtained from the prospective Malmö Diet and Cancer Study (MDCS) conducted 1991–1996. Diet was assessed at baseline using a validated diet history method. Incident RA case

Subdural hemorrhage, retinal hemorrhages, and encephalopathy are associated with the medical diagnosis of abusive head trauma. These findings have also been observed in children exposed to admitted or witnessed shaking. There are various suggested mechanisms behind these findings. One mechanism is exclusive to intentional shaking, while the other suggested mechanisms are compatible with both inten

BACKGROUND: Sharp force injuries display varying patterns depending on the manner of death (homicide, suicide, accidental). The purpose of this study was to analyse forensic autopsy data to examine the characteristics of sharp force injuries on the extremities, to differentiate between different manners of death and to examine demographic differences.METHODS: This retrospective cohort study utiliz