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Uncovering immune cell-associated genes in breast cancer : based on summary data-based Mendelian randomized analysis and colocalization study

BACKGROUND: Breast cancer, which is the most prevalent form of cancer among women globally, encompasses various subtypes that demand distinct treatment approaches. The tumor microenvironment and immune response are of crucial significance in the development and progression of breast cancer. Nevertheless, there has been scant evidence concerning the genes within breast cancer - specific immune cell

Co-evolutionary dynamics for two adaptively coupled Theta neurons

Natural and technological networks exhibit dynamics that can lead to complex cooperative behaviors, such as synchronization in coupled oscillators and rhythmic activity in neuronal networks. Understanding these collective dynamics is crucial for deciphering a range of phenomena from brain activity to power grid stability. Recent interest in co-evolutionary networks has highlighted the intricate in

Listening with costume : a material-discursive practice

This chapter is a dialogue between practice and theory and between humanand non-human companions about what listening with costume might imply.Whereas hearing is the passive process of perceiving sound through our ears,listening requires attention, understanding and interpretation. It is an active skillthat involves knowledge, memory and our imagination and it may call upon ourother senses. Moreov

An Iterative Ray Tracing Algorithm to Increase Simulation Speed While Maintaining Overall Precision

Ray tracing is a frequently used method for acoustic simulations, valued for its calculation speed and ease of use. Although it is fast, there are no fully ray tracing-based real-time simulation methods or engines. Under real-time restrictions, ray tracing simulations lose precision and the variance inherent in the random simulation method has too much impact on the outcome. In this paper, an algo

Local Differentiation in the Loess Deposition as a Function of Dust Source : Key Study Novo Orahovo Loess Paleosol Sequence (Vojvodina, Serbia)

Typical patterns of the Late Pleistocene loess–paleosol units are preserved in the Novo Orahovo brickyard, Northern Serbia. Presented preliminary luminescence chronology supports the chronostratigraphic interpretations of global isotopic marine climate reconstructions. Magnetic susceptibility and sedimentological evidence exhibit general similarities with the marine oxygen-isotope stratigraphy. Th

High Diversity of Giardia duodenalis Assemblages and Sub-Assemblages in Asymptomatic School Children in Ibadan, Nigeria

Giardia duodenalis is a significant contributor to the burden of diarrheal disease in sub-Saharan Africa. This study assesses the occurrence and molecular diversity of G. duodenalis and other intestinal parasites in apparently healthy children (n = 311) in Ibadan, Nigeria. Microscopy was used as a screening method and PCR and Sanger sequencing as confirmatory and genotyping methods, respectively.

Deep learning searches for vector-like leptons at the LHC and electron/muon colliders

The discovery potential of both singlet and doublet vector-like leptons (VLLs) at the Large Hadron Collider (LHC) as well as at the not-so-far future muon and electron machines is explored. The focus is on a single production channel for LHC direct searches while double production signatures are proposed for the leptonic colliders. A Deep Learning algorithm to determine the discovery (or exclusion

In-beam γ -ray spectroscopy of 94 Ag

A recoil-beta-tagging experiment has been performed to study the excited T= 0 and T= 1 states in the odd–odd N= Z nucleus 94Ag, populated via the 40Ca(58Ni,1p3n)94Ag reaction. The experiment was conducted using the MARA recoil separator and JUROGAM3 array at the Accelerator Laboratory of the University of Jyväskylä. Through correlating fast, high-energy beta decays at the MARA focal plane with pro

Anti-phosphatidylserine antibody levels are low in multigravid pregnant women in a malaria-endemic area in Nigeria, and do not correlate with anti-VAR2CSA antibodies

Anemia is a common malaria-associated complication in pregnant women in endemic regions. Phosphatidylserine (PS) is exposed to the immune system during the massive destruction of red blood cells (RBCs) that accompany malaria, and antibodies against PS have been linked to anemia through destruction of uninfected RBCs. We determined levels of anti-PS IgG antibodies in pregnant women in Ibadan, Niger

Ultra-high field imaging, plasma markers and autopsy data uncover a specific rostral locus coeruleus vulnerability to hyperphosphorylated tau

Autopsy data indicate that the locus coeruleus (LC) is one of the first sites in the brain to accumulate hyperphosphorylated tau pathology, with the rostral part possibly being more vulnerable in the earlier stages of the disease. Taking advantage of recent developments in ultra-high field (7 T) imaging, we investigated whether imaging measures of the LC also reveal a specific anatomic correlation

Surface guided electron FLASH radiotherapy for canine cancer patients

BackgroundDuring recent years FLASH radiotherapy (FLASH-RT) has shown promising results in radiation oncology, with the potential to spare normal tissue while maintaining the antitumor effects. The high speed of the FLASH-RT delivery increases the need for fast and precise motion monitoring to avoid underdosing the target. Surface guided radiotherapy (SGRT) uses surface imaging (SI) to render a 3D

LuMaMi28 : Real-Time Millimeter-Wave Multi-User MIMO Systems with Antenna Selection

This paper presents LuMaMi28, a real-time 28GHz multi-user (MU) multiple-input multiple-output (MIMO) testbed. In this testbed, the base station has 16 transceiver chains with a fully-digital beamforming architecture (with different pre-coding algorithms) and simultaneously supports multiple user equipments (UEs) with spatial multiplexing. The UEs are equipped with a beam-switchable antenna array

Caveolin-1 genotypes as predictor for locoregional recurrence and contralateral disease in breast cancer

Purpose: Caveolin-1 (CAV1) has been implicated in breast cancer oncogenesis and metastasis and may be a potential prognosticator, especially for non-distant events. CAV1 functions as a master regulator of membrane transport and cell signaling. Several CAV1 SNPs have been linked to multiple cancers, but the prognostic impact of CAV1 SNPs in breast cancer remains unclear. Here, we investigated CAV1

Spherical White with Diamond

Site-specific public work, commissioned by NATUR North Atlantic Tales/Curated Place in collaboration with National Trust Formby. The work includes three sound installations: 'Spherical White with Diamond', stereo work (voice: Jez Dolan). 'Þytur', 9 mono-channels (voices: Maja Jantar, Angela Rawlings, Halla Steinunn Stefánsdóttir). 'The Shadowy Space Beneath', a stereo work, which builds on texts f

Image Processing

Image processing provides tools for image enhancement and extraction of information from images. Modification of the colour table allows for amplification of the contrast in certain pixel-value intervals while the contrast is suppressed in other intervals. This can in turn be used to selectively enhance the displayed image in intervals of special importance to the current problem. One of the most