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Care for Sound. Sound Environment, Healing & Health Care

Resarch shows the importance of sound environment in health care for healing processses to be effective. Intensive care environments are often caracterized by heavy work load for staff in combination with underdimensioned localities, personel and economy. Results are stress and tension that also affects the well being and recovery for patients. To find yourself in an intensive care unit has more t

New Mediators and Novel Mechanisms in Allergic Airway Inflammation

Hyperresponsiveness and inflammation are major pathophysiological features of both allergic rhinitis and asthma. The mechanisms behind these are not fully understood. The aims of this thesis were to investigate if cytokines involved in the allergic response can induce airway hyperreactivity by affecting the airway smooth muscle directly and to identify novel mediators involved in allergic airway i

Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease

Background and Aim: A recent study in Indian subjects suggested common variants in apolipoprotein C3 (APOC3) (T-455C at rs2854116 and C-482T at rs2854117) to contribute to non-alcoholic fatty liver disease (NAFLD), plasma apoC3 and triglyceride concentrations. Our aim was to determine the contribution of genetic variation in APOC3 on liver fat content and plasma triglyceride and apoC3 concentratio

Inhibition kinetics of catabolic dehydrogenases by elevated moieties of ATP and ADP - implication for a new regulation mechanism in Lactococcus lactis

ATP and ADP inhibit, in varying degrees, several dehydrogenases of the central carbon metabolism of Lactococcus lactis ATCC 19435 in vitro, i.e. glyceraldehyde-3-phosphate dehydrogenase (GAPDH), lactate dehydrogenase (LDH) and alcohol dehydrogenase (ADH). Here we demonstrate mixed inhibition for GAPDH and competitive inhibition for LDH and ADH by adenine nucleotides in single inhibition studies. T

Characterization of oil and starch accumulation in tubers of Cyperus esculentus var. sativus (Cyperaceae): A novel model system to study oil reserves in nonseed tissues

Premise of the study: Storage oil (triacylglycerol) accumulates in tissues such as the embryo and endosperm of seeds and the fruit mesocarp, but seldom in underground organs. As a rare exception, cultivated variants of yellow nutsedge (Cyperus esculentus) contain high amounts of both oil and starch in the mature tubers. Methods: Biochemical analyses and light and electron microscopy were used to s

The Service Triad: Modelling Dialectic Tensions in Service Encounters

SUMMARY: Models of service encounters are often fraught by reductionism, describing business relationships as mathematical combinations of dyadic constellations. Metaphors of ideal social relationships (marriages or friendships) are highlighted to stress normative aspects of equal, balanced and long-term business partnerships. However, these approaches are limited in their analytical sensitivity,

Strength tests of glulam beams with quadratic holes - Test report

This report deals with strength tests of glulam beams with quadratic holes with rounded corners. A total of 36 individual tests were carried out, divided into nine test series with four nominally equal tests in each test series. There were four para\-meters varied within these test series: beam size, bending moment to shear force ratio, material strength class and also hole placement with respect

A Metabolic Study of Huntington's Disease.

Huntington's disease patients have a number of peripheral manifestations suggestive of metabolic and endocrine abnormalities. We, therefore, investigated a number of metabolic factors in a 24-hour study of Huntington's disease gene carriers (premanifest and moderate stage II/III) and controls.

Does Allergen-specific Immunotherapy Induce Contact Allergy to Aluminium?

Persistent, itching nodules have been reported to appear at the injection site after allergen-specific immuno-therapy with aluminium-precipitated antigen extract, occasionally in conjunction with contact allergy to aluminium. This study aimed to quantify the development of contact allergy to aluminium during allergen-specific immunotherapy. A randomized, controlled, single-blind multicentre study

Reduced macular function in ABCA4 carriers.

To study retinal function and morphology in ABCA4 carriers to investigate if ABCA4 carriership is associated with any functional or morphological changes and, if so, to explore whether certain mutations may be associated with particularly severe alterations.

Light Higgs bosons in phenomenological NMSSM

We consider scenarios in the next-to-minimal supersymmetric model (NMSSM) where the CP-odd and charged Higgs bosons are very light. As we demonstrate, these can be obtained as simple deformations of existing phenomenological MSSM benchmarks scenarios with parameters defined at the weak scale. This offers a direct and meaningful comparison to the MSSM case. Applying a wide set of up-to-date constra

Internal Simulation of Perceptions and Actions

We present a study of neural network architectures able to internally simulate perceptions and actions. All these architectures employ the novel Associative Self-Organizing Map (A-SOM) as a perceptual neural network. The A-SOM develops a representation of its input space, but in addition also learns to associate its activity with an arbitrary number of additional (possibly delayed) inputs. One arc

Bönder som värnare – beväpning, status och uppror : feodala kontrapunkter i Europa i ett longue durée-perspektiv ca 1000–1800

Peasant revolts in Europe in the period 1000–1800 often involved militarized peasants. In Western Europe, this appeared in particular between 1300 and 1500 in connection with the late medieval process of militarization of the population. After the sixteenth century a similar process took place in central and Eastern Europe, where the revolts tended to be dominated by border and frontier population

The Archaeology of Time travel – An introduction

This article introduces the concept of Time Travel as a new way to approach the past in our age. The article deals with the question: What role does the past play for people in our time? The time travel discussion focusses on the following themes: Time travel between materality and virtuality; Time travel on the market of experiences; Designing time travel; Evaluating time travel.

Pharmacokinetics and pharmacodynamics of pentoxifylline and metabolites

Pentoxifylline is a haemorheologic drug with complex pharmacokinetics and pharmacodynamics due to both reversible metabolism and the formation of active metabolites. In humans, pentoxifylline is metabolised to at least seven phase 1 metabolites (M1-M7). The reversible metabolism of pentoxifylline to the enantiomers of M1 has only been partly studied. This thesis investigates the pharmacokinetics

Geochronology of high-pressure mafic granulite dykes in SW Sweden; tracking the P-T-t path of metamorphism using Hf isotopes in zircon and baddeleyite

Although the U-Pb zircon chronometer has been widely used for dating metamorphism in moderate to high-grade rocks, it is generally difficult to link the U-Pb age of zircon to specific metamorphic reactions. In this study, the initial Hf isotopic composition of secondary zircon is compared with the evolution of Hf isotopic composition of the bulk sample, back-projected from the measured value throu