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Dendrokronologisk analys av huvudbyggnaden Vita Holmen på Löwenströmska sjukhuset, Upplands Väsby
Upper airway microbiome transplantation for patients with chronic rhinosinusitis
Background: Chronic or recurrent rhinosinusitis without polyps (CRSsNP) is characterized by a persistent inflammation of the sinonasal mucosa. The underlying cause is unclear but increasing interest has been directed toward changes in the sinonasal microbiome as a potential driver. Methods: Twenty-two patients diagnosed with CRSsNP were treated with antibiotics for 13 days, followed by 5 consecuti
Should Benzodiazepines be Used for Reducing Dyspnea in Patients with Advanced Illnesses?
Dyspnea is a common and highly distressing symptom in patients with advanced illnesses. Many patients continue to experience chronic dyspnea despite optimal management of underlying disease(s) and various non-pharmacologic interventions, necessitating the consideration of pharmacologic therapies for palliation of dyspnea. One commonly asked question by clinicians is whether benzodiazepines have a
Imaging Studies of Olfaction in Health and Parkinsonism
Olfactory loss is a common non-motor symptom of Parkinson’s disease (PD), often preceding the cardinal motor symptoms of the disease. The aim of this thesis was to: (a) evaluate whether olfactory examination can increase diagnostic accuracy, and (b) study the structural and functional neural basis of olfactory dysfunction in PD with different applications of Magnetic Resonance Imaging (MRI).Paper
Methods for anti-factor VIII antibody levels in haemophilia A patients-validation of a multiplec immunoassay and comparability with assays measuring non-neutralising and neutralising antibodies (inhibitors)
IntroductionThe development of neutralising (inhibitors) and non-neutralising antibodies (NNAs) is a complication to factor replacement therapy in haemophilia. The diagnostic methods available lack standardisation, have high inter-laboratory variation, and false-negative as well as false-positive results may affect treatment. Both functional inhibitors and NNAs may be detected with higher reproduc
From Big Bang to Big Data : A History of the Media
Does media history really start with a bang? More than just newspapers, television, and social networks, media are the means by which any information is communicated, from cosmic radiation traces to medieval church bells to modern identity documents. Cultures are held together as much by bookkeeping and records as they are by stories and myths.From Big Bang to Big Data is a long history of the med
Pollen based landcover reconstructions help to reveal past climate–human–land-cover interactions in Europe (LANDCLIM2)
Mapping trait versus species turnover reveals spatiotemporal variation in functional redundancy and network robustness in a plant-pollinator community
Functional overlap among species (redundancy) is considered important in shaping competitive and mutualistic interactions that determine how communities respond to environmental change. Most studies view functional redundancy as static, yet traits within species—which ultimately shape functional redundancy—can vary over seasonal or spatial gradients. We therefore have limited understanding of how
Women’s experience of sexuality after radical cystectomy–a qualitative study
Purpose: The aim of this study was to explore how women experienced sexuality after radical cystectomy due to bladder cancer. Methods: We performed an interview study with qualitative design with content analysis. Inclusion criteria were age below 75 years. In total 10 women, with a median age of 64 years at surgery, were interviewed at median 24 months post radical cystectomy. Results: The 10 wom
European Stabilisation Policy After the COVID-19 Pandemic: More Flexible Integration or More Federalism?
Crises are a major driving force behind cooperation in the European Union. During severe crises, cooperation has been enlarged and intensified. The Ukrainian war and the covid-19 pandemic are two examples of this pattern, not least when it comes to the conduct of stabilization policies in the EU. In this chapter, we discuss the implications for the EU of a move towards increased fiscal federalism.
Examining Legitimacy in Government Agencies’ Crisis Communication
Governments exercise power over the public in many ways. One clear example is during societal crises when government agencies engage in purposeful strategic communication, issue restrictions and recommendations, and rely on people’s compliance to reach response objectives and meet needs in society. Here, issues of authority and legitimacy are crucial. In this study, we are interested in how this p
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Cooling strategies during neonatal transport for hypoxic-ischaemic encephalopathy
Aim: We reviewed the literature on cooling methods during transport of newborn infants with hypoxic-ischaemic encephalopathy (HIE) born in a non-tertiary centre and transferred to a neonatal intensive care unit for therapeutic hypothermia. Methods: The electronic databases CENTRAL, MEDLINE, Embase, CINAHL, and Scopus were searched from inception up to 8 March 2022 for studies comparing cooling ver
A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ42 Aggregation
The aggregation of the amyloid β (Aβ) peptide is one of the molecular hallmarks of Alzheimer’s disease (AD). Although Aβ deposits have mostly been observed extracellularly, various studies have also reported the presence of intracellular Aβ assemblies. Because these intracellular Aβ aggregates might play a role in the onset and progression of AD, it is important to investigate their possible origi
Simulations of phase transitions and capacitance, of simple ionic fluids in porous electrodes
In this work, we simulate the capacitance of a simple charged fluid model consisting of equal-sized, spherical monovalent ions, immersed in an implicit solvent. Apart from Coulomb forces, the particles interact via a truncated and shifted Lennard-Jones potential. This is a possible crude model for hydrophobic ions (assuming an implicit aqueous solvent) and allows for a possible demixing transition
Machine learning-assisted parameter identification for constitutive models based on concatenated loading path sequences
A hybrid strategy for the identification of material parameters of constitutive models is presented. One main challenge in the context of classic optimisation-based parameter identification schemes is the generation of adequate starting values for the multi-objective optimisation procedure. We address this issue by employing an artificial neural network that is trained with data obtained from the
Factors influencing self-management behavior during the “Blanking Period” in patients with atrial fibrillation : A cross-sectional study based on the information-motivation-behavioral skills model
Background: Atrial fibrillation (AF) is becoming increasingly common. Effective self-management during the “Blanking Period” is critical. The Information-Motivation-Behavioral skills (IMB) model can be used to study health behaviors in chronic disease patients, but it has not been studied in AF patients. Objective: The goal of this study was to explore the influencing factors and interaction pathw
HPAEC-PAD analysis for determination of the amino acid profiles in protein fractions from oat flour combined with correction of amino acid loss during hydrolysis
Current derivatization-dependent approaches for amino acid composition analysis of cereal proteins have significant variability due to lack of direct analysis opportunities and loss of amino acids during protein-hydrolysis. To tackle these drawbacks, a novel direct, derivatization-free approach was successfully introduced, using HPAEC-PAD, and applied for analysis of hydrolyzed defatted oat flour
Experimental test on the performance of a −80 °C cascade refrigeration unit using refrigerants R290-R170 for COVID-19 vaccines storage
With the urgent demand for ultralow-temperature refrigerators worldwide, the operation reliability and stability of the refrigeration system becomes greatly crucial. In this study, a -80 oC ultralow-temperature cascade refrigeration system (CRS) is developed. From aspects of global warming potential (GWP) and ozone depletion potential (ODP), the environmentally friendly refrigerants R290 and R170