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In this issue of Journal of Endocrinology, Dr Han and colleagues report a protective effect of the glutamate dehydrogenase-activator BCH under diabetes-like conditions that impair β-cell function in both a pancreatic β-cell line and in db/db mice. Based on these observations, the authors suggest that BCH could serve as novel treatment modality in Type 2 Diabetes. The present commentary discusses t

There is general consensus in the study of science, and especially research policy studies, that a wave of profound change has struck academic science in the past decades. Central parts of this change are increased competition, growing demands of relevance and excellence, and managerialism reforms in institutions and policy systems. The underpinning thesis of this article is that, if seen from the

The paper is devoted to modeling wireless mesh networks (WMN) through mixed-integer programming (MIP) formulations that allow to precisely characterize the link data rate capacity and transmission scheduling using the notion of time slots. Such MIP models are formulated for several cases of the modulation and coding schemes (MCS) assignment. We present a general way of solving the max–min fairness

Age-related decline in cardiac function can be prevented or postponed by lifelong endurance training. However, effects of normal ageing as well as of lifelong endurance exercise on longitudinal and radial contribution to stroke volume are unknown. The aim of this study was to determine resting longitudinal and radial pumping in elderly athletes, sedentary elderly and young sedentary subjects. Furt

Abstract Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. In the last decades numerous markers have been considered and investigated for the prediction of CV events, but only a few of them resulted in improved global risk assessment beyond traditional risk factors when incorporated into coronary evaluation scores. Recent genetic studies have pointed out a few bu

Fear of falling can be conceptualized in different ways, e.g., as concerns about falling or low fall-related self-efficacy. It is common in people with Parkinson's disease (PD), and there is growing knowledge about its contributing factors. However, previous multivariate studies have mainly focused on fear of falling in relation to PD-related disabilities, and less is known about the associations

BackgroundOak moss absolute, an extract from the lichen Evernia prunastri, is a valued perfume ingredient but contains extreme allergens. ObjectivesTo compare the elicitation properties of two preparations of oak moss absolute: classic oak moss', the historically used preparation, and new oak moss', with reduced contents of the major allergens atranol and chloroatranol. Patients/materials/methodsT

Aims/hypothesis There has been long-standing debate about whether diabetes is a causal risk factor for pancreatic cancer or a consequence of tumour development. Prospective epidemiological studies have shown variable relationships between pancreatic cancer risk and blood markers of glucose and insulin metabolism, overall and as a function of lag times between marker measurements (blood donation) a

The acoustic cavitation phenomenon is a source of energy for a wide range of applications such as sonoluminescence and sonochemistry. The behavior of a single bubble in liquids is an essential study for acoustic cavitation. The bubbles react with the pressure forces in liquids and reveal their full potential when periodically driven by acoustic waves. As a result of extreme compression of the bubb

Det reformerade allmänna svenska pensionssystemet har hyllats av många, inte minst av dem som deltagit i själva utarbetandet av systemet, men hur upplevs några av de mer grundläggande antagandena bakom reformen av dem det avser att ge ekonomiskt skydd åt på ålderdomen? Genom ett omfattande djupintervjumaterial visar Lars Harrysson och Erika Werner att det finns såväl stöd som brist på det samma fö

Background. Oestrogen receptor (ER) status is important for the choice of systemic treatment of breast cancer patients. However, most data from randomised trials on the effect of adjuvant endocrine therapy according to ER status are based on the cytosol methods. Comparisons with immunohistochemical methods have given similar results. The aim of the present study was to examine whether different ER

The aim of the present study was to report independent correlates of ecstasy use in the Swedish general population. Data were drawn from a Swedish national household survey conducted in 2008-2009 on a random, stratified sample of 58,000 inhabitants of Sweden, aged 15 to 64. The response rate was 38.3%. Logistic regression analysis was used to identify correlates of recent (past-year) and former ec

The largest perturbation on upper trophic levels of many marine ecosystems stems from fishing. The reaction of the ecosystem goes beyond the trophic levels directly targeted by the fishery. This reaction has been described either as a change in slope of the overall size spectrum or as a trophic cascade triggered by the removal of top predators. Here we use a novel size- and trait-based model to ex

The gene encoding thymidine kinase 1 from tomato (toTK1) has in combination with azidothymidine (AZT) recently been proposed as a powerful suicide gene for anticancer gene therapy. The toTK1/AZT combination has been demonstrated to have several advantages for the treatment of glioblastomas because AZT can easily penetrate the blood-brain barrier and toTK1 can efficiently phosphorylate AZT and also

Introduction: We conducted a prospective observational study in cardiac arrest survivors treated with mild induced hypothermia, evaluating different platelet function tests at hypo-and normothermia. We also investigated the relation between gastric emptying and vasodilator stimulated phosphoprotein (VASP). Methods: Comatose survivors of out of hospital cardiac arrest were included and divided into

Inexpensive and environmentally friendly electrolyte polymers that can be operated at higher temperatures and drier conditions are highly interesting for PEM fuel cells for automotive, portable power and stationary electricity generation applications. In this study an ionomer based on polysulfone grafted with poly(vinylphosphonic acid) (PSUgPVPA) in the cathode Pt/C catalyst layer (CL) was electro

The opinions of legal professionals about child and adult witnesses might influence the likelihood that a case is allowed to proceed through the different stages of the legal process. With the aim of knowing the opinions of legal practitioners about child and adult witnesses, 84 legal professionals (Swedish police, prosecutors, and attorneys) were surveyed about their beliefs about child and adult