Sökresultat

Filtyp

Din sökning på "*" gav 529856 sökträffar

Local CTLA4 blockade effectively restrains experimental pancreatic adenocarcinoma growth in vivo.

Antibody-mediated blockade of CTLA4 has been shown to be effective in treating a select group of patients with late-stage melanoma. The precise mechanism underlying the clinical activity of CTLA4 immunotherapy is poorly understood, although recent experimental findings indicate that antibody-mediated depletion of regulatory T cells (Tregs) in the tumor microenvironment plays a key role in efficaci

Variation in turbidity with precipitation and flow in a regulated river system - river Gota Alv, SW Sweden

The turbidity variation in time and space is investigated in the downstream stretch of the river Gota Alv in Sweden. The river is heavily regulated and carries the discharge from the largest fresh water lake in Sweden, Lake Vanern, to the outflow point in Goteborg Harbour on the Swedish west coast. The river is an important waterway and serves as a fresh-water supply for 700 000 users. Turbidity i

Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition.

There are inconsistent and limited data available to assess the relationship between fat intake and risk of epithelial ovarian cancer (EOC). We examined the consumption of total fat, fat sources and fat subtypes in relation to risk of EOC and its major histologic subtypes in the European Prospective Investigation into Cancer and Nutrition which includes incident invasive (n=1095) and borderline (n

Acute Traumatic Brain Injury Mortality in the elderly.

Despite recent progress, prognosis for the elderly (defined as aged 70 or more) afflicted by Traumatic Brain Injury (TBI) is unfavorable and surgical intervention remains controversial. Research during the last decade on the mortality rates or prognostic factors for survival in the elderly is limited.

In vivo evaluation of large-scale IR-based traceability recovery

Modern large-scale software development is a complex undertaking and coordinating various processes is crucial to achieve efficiency. The alignment between requirements and test activities is one important aspect. Production and maintenance of software result in an ever-increasing amount of information. To be able to work efficiently under such circumstances, navigation in all available data needs

Audio Feedback with Reduced Self-focus as an Intervention for Social Anxiety: An Experimental Study.

Socially anxious individuals tend to underestimate their performance largely due to attentional bias. Video and audio feedback (AF) with cognitive preparation (CP) have shown to improve socially anxious individuals' evaluation of their performance in previous studies. In the present study, it was hypothesized that one of the three steps in CP, reduced self-focus (RS), is sufficient to cause an imp

Migrants' Integration in Western Europe: Bridging Social Psychology and Political Science

This article presents the possibilities and advantages of integrating social psychology and political science in the study of intergroup relations in diverse societies in Western Europe. Social psychology provides interesting insights in understanding the emotional and cognitive consequences of increased diversity. However, this literature tends to overlook the role of institutional discourses and

Solar forcing as an important trigger for West Greenland sea-ice variability over the last millennium

Arctic sea ice represents an important component of the climate system, and the present reduction of sea ice in the Arctic is of major concern. Despite its importance, little is known about past changes in sea-ice cover and the underlying forcing mechanisms. Here, we use diatom assemblages from a marine sediment core collected from the West Greenland shelf to reconstruct changes in sea-ice cover o

The hematopoietic tumor suppressor interferon regulatory factor 8 (IRF8) is upregulated by the antimetabolite cytarabine in leukemic cells involving the zinc finger protein ZNF224, acting as a cofactor of the Wilms' tumor gene 1 (WT1) protein.

The transcription factor interferon regulatory factor-8 (IRF8) is highly expressed in myeloid progenitors, while most myeloid leukemias show low or absent expression. Loss of IRF8 in mice leads to a myeloproliferative disorder, indicating a tumor-suppressive role of IRF8. The Wilms tumor gene 1 (WT1) protein represses the IRF8-promoter. The zinc finger protein ZNF224 can act as a transcriptional c

Pelagic-benthic coupling within an upwelling system of the subtropical northeast Atlantic over the last 35 ka BP

We present a high resolution, multiproxy study of the relationship between pelagic and benthic environments of a coastal upwelling system in the subtropical NE Atlantic Ocean. Marine sediments corresponding to late MIS3 to the Holocene in the radiocarbon dated core GeoB7926, retrieved off Mauritania (21 degrees N) were analysed to reconstruct productivity in surface waters and its linkage to deep

A new key pole for the East European Craton at 1452 Ma: Palaeomagnetic and geochronological constraints from mafic rocks in the Lake Ladoga region (Russian Karelia)

Palaeomagnetic and geochronological studies on mafic rocks in the Lake Ladoga region in South Russian Karelia provide a new, reliably dated Mesoproterozoic key paleopole for the East European Craton (Baltica). U-Pb dating on baddeleyite gives a crystallisation age of 1452 +/- 12 Ma for one of the studied dolerite dykes. A mean palaeomagnetic pole for the Mesoproterozoic dolerite dykes. Valaam sill

Furongian (Cambrian) agnostoids of Scandinavia and their implications for intercontinental correlation

Out of the 14 agnostoid species/subspecies so far recorded from the Furongian of Scandinavia, seven are excellent biostratigraphical indices and important for correlation between Baltica and other palaeocontinents. Glyptagnostus reticulatus, Aspidagnostus lunulosus and Agnostus (Homagnostus) obesus first appear at the base of the G. reticulatus Zone, allowing a precise correlation of the base of t

Dispersion of overdamped diffusing particles in channel flows coupled to transverse acoustophoretic potentials: Transport regimes and scaling anomalies

We address the dispersion properties of overdamped Brownian particles migrating in a two-dimensional acoustophoretic microchannel, where a pressure-driven axial Stokes flow coexists with a transverse acoustophoretic potential. Depending on the number and symmetries of the stable nodal points of the acoustophoretic force with respect to the axial velocity profile, different convection-enhanced disp

Search for dark matter in events with a Z boson and missing transverse momentum in pp collisions at root s=8 TeV with the ATLAS detector

A search is presented for production of dark-matter particles recoiling against a leptonically decaying Z boson in 20.3 fb(-1) of pp collisions at root s = 8 TeV with the ATLAS detector at the Large Hadron Collider. Events with large missing transverse momentum and two oppositely charged electrons or muons consistent with the decay of a Z boson are analyzed. No excess above the Standard Model pred

Polymer leaching from film coating: Effects on the coating transport properties.

The release mechanism of metoprolol succinate pellets coated with a blend of a water-insoluble polymer, ethyl cellulose (EC), and a water-soluble polymer, hydroxypropyl cellulose (HPC) is mechanistically explained. The kinetics of drug release and HPC leaching were followed for drug doses. The coating was initially not permeable to the drug, and release started only after a critical amount of the

Contact allergy from disperse dyes in textiles-a review.

Several disperse dyes (DDs) are still considered to be the most important allergens in textile dermatitis, but there are sparse data about their current use in textiles. The aim of this review was to evaluate published studies and reports on contact allergy to DDs published in PubMed during the last 22 years (1990-2012). Prevalence data are provided by study and by dye, as well as by the described

Modification of Human-Biometeorologically Significant Radiant Flux Densities by Shading as Local Method to Mitigate Heat Stress in Summer within Urban Street Canyons

Increasing heat will be a significant problem for Central European cities in the future. Shading devices are discussed as a method to mitigate heat stress on citizens. To analyze the physical processes, which are characteristic of shading in terms of urban human-biometeorology, experimental investigations on the thermal effects of shading by a building and shading by tree canopies were conducted i