Chromothripsis is a mutational phenomenon characterized by massive, clustered genomic rearrangements that occurs in cancer and other diseases. Recent studies in selected cancer types have suggested that chromothripsis may be more common than initially inferred from low-resolution copy-number data. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Can

We introduce the notion of a-walk S(n) = a1X1 +… + anXn, based on a sequence of positive numbers a = (a1, a2,…) and a Rademacher sequence X1,X2,…. We study recurrence/ transience (properly defined) of such walks for various sequences of a.

Heterotopic mineralization entails pathological mineral formation inside soft tissues. In human tendons mineralization is often associated with tendinopathies, tendon weakness and pain. In Achilles tendons, mineralization is considered to occur through heterotopic ossification (HO) primarily in response to tendon pathologies. However, refined details regarding HO deposition and microstructure are

This paper analyzes the problem and requirements of securely distributing software updates over the Internet,to devices in an Industrial Control System (ICS) and more generally in Internet of Things (IoT) infrastructurescontrolling a physical system, such as power grids and water supply systems. We present a novel approachthat allows to securely distribute software updates of different types, e.g.

While process improvement is an increasingly important topic for organizations, academic institutions find it hard to teach the topic in a cross functional real world project manner. This paper describes a unique course which is theoretically sound, academically rigorous, multi-disciplinary, and practically relevant while providing the students with a transformational learning opportunity. The cou

The prevalence of obesity has reached pandemic proportions, and now approximately 25% of adults in Westernized countries have obesity. Recognized as a major health concern, obesity is associated with multiple comorbidities, particularly cardiometabolic disorders. In this Review, we present obesity as an evolutionarily novel condition, summarize the epidemiological evidence on its detrimental cardi

Although masculinity is a powerful concept in both sociology and gender studies, previous research forgot to analyse sex work under this perspective. Even though the actors involved are men, and previous studies have highlighted the importance of masculinity not only in the relation manto- woman but also in the “gay world”, there is a lack of attention in male sex working. Then, the aim of this pa

Purpose: To demonstrate the feasibility and accuracy of chemical shift–encoded imaging of the fatty acid composition (FAC) of human bone marrow adipose tissue at 7 T, and to determine suitable image-acquisition parameters using simulations. Methods: The noise performance of FAC estimation was investigated using simulations with a range of inter-echo time, and accuracy was assessed using a phantom

Införandet av människoexploateringsbrottet i 4 kap. 1 b § BrB aktualiserar ett antal frågor som tidigare inte behandlats i praxis. Bestämmelsen prövades för första gången av Högsta domstolen i NJA 2022 s. 23, vilket är det avgörande denna artikel kommenterar. Författaren visar att domstolen ställt upp en ordning för hur prövningen ska gå till, diskuterar innebörden av rekvisitet exploatering samt

starting point. Through active participation as an urban sketcher through digital publishing,dialogue and interaction, I analyze my analytical process and urban sketching practice. Theaim is to examine ethnographic drawing as a visual cultural analytical method. My contributionis based the connection between urban ideals and innovative, creative environments in alocal context. An overall knowledgeIn this article I have chosen a contemporary phenomenon, urban sketching, as an empirical starting point. Through active participation as an urban sketcher through digital publishing, dialogue and interaction, I analyze my analytical process and urban sketching practice. The aim is to examine ethnographic drawing as a visual cultural analytical method. My contribution is based the connection betwe

Background: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is an emerging and potentially life-saving procedure, necessitating qualified operators in an increasing number of centres. The procedure shares technical elements with other vascular access procedures using the Seldinger technique, which is mastered by doctors not only in endovascular specialties but also in trauma surg

This chapter gives an introduction to the European Research Infrastructure Consortium (ERIC) – a European Union (EU) policy tool introduced in 2009 with the purpose to set up and operate collaborative Research Infrastructures by granting them a legal personality and qualities of an international organization. The shared responsibility between the member states and the EU in the research and innova

The extent to which plants thermoregulate to maintain relatively stable metabolic function in response to gradual and rapid temperature changes that jeopardize crop production is unclear. Maize thermoregulation was investigated based on leaf temperature (TL) measurements and its relationship with photochemistry and stomatal conductance (gs) under dry and wet soil scenarios. Seasonal climatology wa

Time-resolved analysis of photon cross-correlation function g(2)(τ) is applied to photoluminescence (PL) of individual submicrometer size MAPbI3 perovskite crystals. Surprisingly, an antibunching effect in the long-living tail of PL is observed, while the prompt PL obeys the photon statistics typical for a classical emitter. We propose that antibunched photons from the PL decay tail originate from

This paper analysis sexual scripts theory in relation to gay men courtship, love relationships, and casual sex. The aim is to understand how gay masculinity is evolving in the 21st Century. Previous research has reinforced the concept that gay men follow heterosexual masculinity and scripts in their relationships with other men. Here, analysing data from the most used gay dating app ‘Grindr’, we t

There is confusion regarding the dynamics of the umbilical cord circulation and the concomitant placental transfusion. How long does it continue, and at what rate? These questions remain an enigma for many. In this article we will address some common misconceptions about the management of cord circulation, try to explain why there is a lack of clarity, and call in to question the conclusions from

Suspensions of microswimmers are a class of systems inherently out of equilibrium, due to the mechanical work continuously performed by a large number of active agents. Biological examples are plentiful, as many aquatic microorganisms have the ability to propel themselves. A distinct phenomenon displayed by such systems is the increased diffusivity of passive tracer particles, relative to their eq