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CODUSA - Customize Optimal Donor Using Simulated Annealing In Heart Transplantation.

In heart transplantation, selection of an optimal recipient-donor match has been constrained by the lack of individualized prediction models. Here we developed a customized donor-matching model (CODUSA) for patients requiring heart transplantations, by combining simulated annealing and artificial neural networks. Using this approach, by analyzing 59,698 adult heart transplant patients, we found th

The influence of different stresses on glomalin levels in an arbuscular mycorrhizal fungus-salinity increases glomalin content.

Glomalin is a glycoprotein produced by arbuscular mycorrhizal (AM) fungi, and the soil fraction containing glomalin is correlated with soil aggregation. Thus, factors potentially influencing glomalin production could be of relevance for this ecosystem process and for understanding AM fungal physiology. Previous work indicated that glomalin production in AM fungi may be a stress response, or relate

Low bone mineral density is associated with increased mortality in elderly men: MrOS Sweden

We studied the nature of the relationship between bone mineral density (BMD) and the risk of death among elderly men. BMD was associated with mortality risk and was independent of adjustments for other co-morbidities. A piecewise linear function described the relationship more accurately than assuming the same gradient of risk over the whole range of BMD (p = 0.020). Low BMD was associated with a

Bayesian Inference for Nonlinear Dynamical Systems : Applications and Software Implementation

The topic of this thesis is estimation of nonlinear dynamical systems, focusing on the use of methods such as particle filtering and smoothing. There are three areas of contributions: software implementation, applications of nonlinear estimation and some theoretical extensions to existing algorithms. The common theme for all the work presented is the pyParticleEst software framework, which has b

On the Generalization of the GMS Evolutionary Model

We study a generalization of the evolution model proposed by Guiol, Machado and Schinazi [4]. In our model, at each moment of time a random number of species is either born or removed from the system; the species to be removed are those with the lower fitnesses, fitnesses being some numbers in [0, 1]. We show that under appropriate conditions, a set of species approaches (in some sense) a sample f

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The aim of our work was to calculate basic mathematical characteristics of payment functional, such as mathematical expectation, variation and expected risk in discrete and continuous market models. In our paper we present a model of financial market in which the entire time interval in the continuous model is divided into steps with exponential distribution, and in the discrete model into steps o

Effects of linear amphiphilicity on membrane interactions of C-terminal thrombin peptides

Effects of linear amphiphilicity on membrane interactions of antimicrobial peptides were investigated by ellipsometry, dual polarization interferometry, fluorescence spectroscopy, light scattering, and circular dichroism. In doing so, the thrombin-derived GKY25 (GKYGFYTHVFRLKKWIQKVIDQFGE) was compared to WFF25 (WFFFYYLIIGGGVVTHQQRKKKKDE) of identical composition, but with amino acids sorted accord

Insights Into the Molecular Mechanism for Type 2 Diabetes Susceptibility at the KCNQ1 Locus From Temporal Changes in Imprinting Status in Human Islets

The molecular basis of type 2 diabetes predisposition at most established susceptibility loci remains poorly understood. KCNQ1 maps within the 11p15.5 imprinted domain, a region with an established role in congenital growth phenotypes. Variants intronic to KCNQ1 influence diabetes susceptibility when maternally inherited. By use of quantitative PCR and pyrosequencing of human adult islet and fetal

Semi-empirical atomistic study of point defect properties in BCC transition metals

We have constructed a set of embedded atom method (EAM) potentials for Fe, Ta, W and V and used them in order to study point defect properties. The parametrizations of the potentials ensure that the third order elastic constants are continuous and they have been fitted to the cohesive energies, the lattice constants, the unrelaxed vacancy formation energies and the second order elastic constants.

Evaluation of Level of Confidence and Optimization of Roll-back Recovery with Checkpointing for Real-Time Systems

Increasing soft error rates for semiconductor devices manufactured in later technologies enforce the usage of fault tolerant techniques such as Roll-back Recovery with Checkpointing (RRC). As RRC introduces time overhead that increases the completion (execution) time, time constraints (deadlines) might be violated. This is a drawback for a class of computer systems where the correct operation is d

Endoscopic assessment and grading of Barrett's esophagus using magnification endoscopy and narrow band imaging: Impact of structured learning and experience on the accuracy of the Amsterdam classification system

Objective. Several classification systems have been launched to characterize Barrett's esophagus (BE) mucosa using magnification endoscopy with narrow band imaging (ME-NBI). The good accuracy and interobserver agreement described in the early reports were not reproduced subsequently. Recently, we reported somewhat higher accuracy of the classification developed by the Amsterdam group. The critical

Arterial dysfunction but maintained systemic blood pressure in cavin-1-deficient mice.

Caveolae are omega-shaped plasma membrane micro-domains that are abundant in cells of the vascular system. Formation of caveolae depends on caveolin-1 and cavin-1 and lack of either protein leads to loss of caveolae. Mice with caveolin-1 deficiency have dysfunctional blood vessels, but whether absence of cavin-1 similarly leads to vascular dysfunction is not known. Here we addressed this hypothesi

Gut Manifestations in an Experimental Model of Multiple Sclerosis

Multiple sclerosis (MS) is an immune-mediated demyelinating and neurodegenerative disease of the central nervous system (CNS). Neuroinflammatory processes in MS are believed to lead to damage and leakage in the blood-brain barrier that protects the CNS and regulates the trafficking of soluble mediators and leukocytes. MS is thought to be triggered in genetically susceptible individuals following e

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BACQUIN, MARI, Theseus de Cologne, édition partielle d’une chanson de geste du XIVe siècle. Études romanes de Lund, 81, 355 pages. Written in French. Monograph. Theseus de Cologne is a French romance from the fourteenth century written by an anonymous author. This voluminous work contains more than 26,000 lines. The text of the romance is preserved in three manuscripts from the fifteenth century,

Two-particle Aharonov-Bohm effect in electronic interferometers

We review recent theoretical investigations on the two-particle Aharonov-Bohm effect and its relation to entanglement production and detection. The difficulties of the entanglement detection due to dephasing and finite temperature are discussed regarding a recent experimental realization of a two-particle Aharonov-Bohm interferometer [15]. We also discuss a theoretical proposal for a two-particle

Phase transition pathways for the production of 100 nm oil-in-water emulsions

Oil/water emulsions can be produced through phase inversion, by adding water to a reverse water/oil microemulsion. According to small angle neutron scattering experiments and visual observations performed during phase inversion, the stages of this process are as follows: (i) upon water addition, the microemulsion gives way to a highly swollen lamellar phase; (ii) the transient lamellar phase break