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To further our understanding of inherited susceptibility to Hodgkin lymphoma (HL), we performed a meta-analysis of seven genome-wide association studies totalling 5,325 HL cases and 22,423 controls. We identify five new HL risk loci at 6p21.31 (rs649775, P = 2.11 × 10-10), 6q23.3 (rs1002658, P = 2.97 × 10-8), 11q23.1 (rs7111520, P = 1.44 × 10-11), 16p11.2 (rs6565176, P = 4.00 × 10-8) and 20q13.12
Recently, vehicle sharing emerged as a new type of mobility service. In particular, if these systems happen to be free-floating, their operating area is typically located within the city and vehicles could be picked-up and parked in any permitted spot, and not only at predetermined stations. This specific feature enables everyone to pick-up and drop-off a rented vehicle close to his demand points,
Equity refers to a fair sharing of costs or resources. Horizontal equity concerns distribution among individuals or groups with the same necessities, whereas vertical equity should be considered in situations with different levels of needs. This paper deals with transit service, looking at how to make it equitable from a spatial and social point of view. Traditionally equity has been neglected in
Promoting a more sustainable development of urban realities is one of the most important goals of the recent decades. One possible strategy to undertake in order to achieve this objective is the implementation of a road pricing: tolling private cars when passing by certain roads of the network could be a way to tone down the traffic congestion and, at the same time, encourage the shifting towards
Most of the models for solving the transportation Network Design Problem (NDP) often neglect equity goals that, assuming the societal function of transportation systems, should play an important role. The NDP should be addressed to solutions in which the outcomes of the design (costs and/or benefits) are distributed as fairly as possible among the potential users or class of users. In this paper,
The attractiveness of cycling-and in particular of bike-sharing systems-as a sustainable alternative of transportation is constantly growing, given the undeniable benefits associated with it. The aim of this paper is to present a multi-objective model based on a Fuzzy Inference System to be embedded in a mobile application that could assist cyclists in the selection of the smartest route to follow
Background: Geraniol is a widely used fragrance terpene, and is included in fragrance mix I. Geraniol is prone to autoxidation, forming the skin sensitizers geranial, neral, and geraniol-7-hydroperoxide. Oxidized geraniol has previously been patch tested in 1 clinic, giving 1% to 4.6% positive reactions in consecutive patients when tested at 2% to 11%. Aim: To compare test reactions to pure and ox
Paleogeographic proximity of Baltica and Laurentia in the supercontinent Rodinia has been widely accepted. However, robust paleomagnetic poles are still scarce, hampering quantitative tests of proposed relative positions of the two cratons. A recent paleomagnetic study of the early Neoproterozoic Blekinge-Dalarna dolerite (BDD) dykes in Sweden provided a 946–935 Ma key pole for Baltica, but earlie
The Archean Yilgarn Craton in Western Australia hosts at least five generations of Proterozoic mafic dykes, the oldest previously identified dykes belonging to the ca. 2408–2401 Ma Widgiemooltha Supersuite. We report here the first known Archean mafic dyke dated at 2615 ± 6 Ma by the ID-TIMS U-Pb method on baddeleyite and at 2610 ± 25 Ma using in situ SHRIMP U-Pb dating of baddeleyite. Aeromagneti
The origins, evolutionary history and diversification of the Australian butterfly fauna are poorly known and uncertain. Two competing hypotheses have been proposed to explain the occurrence of butterflies on this isolated continental landmass. The common view is that all Australian butterflies entered the continent relatively recently from the northern hemisphere via Southeast Asia and/or mainland
The mass of the Higgs boson is measured in the H→ZZ⁎→4ℓ and in the H→γγ decay channels with 36.1 fb−1 of proton–proton collision data from the Large Hadron Collider at a centre-of-mass energy of 13 TeV recorded by the ATLAS detector in 2015 and 2016. The measured value in the H→ZZ⁎→4ℓ channel is mH ZZ⁎=124.79±0.37GeV, while the measured value in the H→γγ channel is mH γγ=124.93±0.40GeV. Combining
I denna artikel ger jag en förklaring till den för Ruts bok karakteristiska transparensen i guds gärningar. Att JHVH framställs som verksam genom huvudkaraktärerna Rut och Boas goda gärningar har sin grund i bokens etisk-didaktiska syfte. Berättelsen gudomliggör dessa modellfigurers handlingar genom att framställa dem som Guds egna. att JHVH identifierar sig med ett sådant liv i solidaritet visar
GPUs in embedded platforms are reaching performance levels comparable to desktop hardware, thus it becomes interesting to apply Computer Vision techniques. We propose, implement, and evaluate a novel feature detector and descriptor combination, i.e., we combine the Harris-Hessian detector with the FREAK binary descriptor. The implementation is done in OpenCL, and we evaluate the execution time and
AbstractSafe drinking water is far from sterile and can contain 10^3-10^5 bacteria/mL. This water microbiome can be altered through various treatment processes in the drinking water treatment plant (DWTP), particularity when it comes in contact with biofilms. Biofilms cover surfaces in the drinking water systems and contain diverse bacterial communities that interact with the water. In this thesis
This paper examines how a Scandinavian country organises elderly care as a welfare service on a quasi-market. More specifically, it deals with how public officers work with meeting citizens’ need and demand, while at the same time struggle with political decrees, changes in the political climate, as well as the whims of the market. Swedish elderly care is used as an example of how a welfare servic
This paper examines how elderly care is organised as a welfare service on a quasi-market. More specifically, it deals with how public officers work with meeting citizens' need and demand, while at the same time struggle with political decrees, changes in the political climate, as well as the whims of the market. Swedish elderly care is used as an example of how a welfare service is organised on a
The thymus is the primary lymphoid organ where naïve T cells are generated; however, with the exception of age, the parameters that govern its function in healthy humans remain unknown. We characterized the variability of thymic function among 1000 age- and sex-stratified healthy adults of the Milieu Intérieur cohort, using quantification of T cell receptor excision circles (TRECs) in peripheral b
Background: The processes leading to the diversity of over 7000 present-day languages have been the subject of scholarly interest for centuries. Several factors have been suggested to contribute to the spatial segregation of speaker populations and the subsequent linguistic divergence. However, their formal testing and the quantification of their relative roles is still missing. We focussed here o
