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Hydraulic Parameter Estimation for District Heating Based on Laboratory Experiments

In this paper we consider calibration of hydraulic models for district heating networks based on operational data. We extend previous theoretical work on the topic to handle real-world complications, namely unknown valve characteristics and hysteresis. We generate two datasets in the Smart Water Infrastructure Laboratory in Aalborg, Denmark, on which we evaluate the proposed procedure. In the firs

Decentralized PI-control and Anti-windup in Resource Sharing Networks

We consider control of multiple stable first-order systems which have a control coupling described by an M-matrix. These agents are subject to incremental sector-bounded nonlinearities. We show that such plants can be globally asymptotically stabilized to a unique equilibrium using fully decentralized proportional integral anti-windup-equipped controllers subject to local tuning rules. In addition

Interventions to improve outdoor mobility among people living with disabilities: A systematic review

BackgroundAround 15% of the global population live with some form of disabilities and experience worse health outcomes, less participation in the community and are part of fewer activities outside the home. Outdoor mobility interventions aim to improve the ability to move, travel and orient outside the home and could influence the number of activities outside the home, participation and quality of

Chrome-rich spinels in micrometeorites from modern Antarctic sedimentary deposits

Each year, approximately 5000 tons of extraterrestrial material reaches the Earth's surface as micrometeorites, cosmic dust particles ranging from 10 to 2000 μm in size. These micrometeorites, collected from diverse environments, mainly deep-sea sediments, Antarctic ice, snow and loose sediments, and hot deserts, are crucial in understanding our Solar System's evolution. Chrome-rich spinel (Cr-spi

Sequential drug treatment targeting cell cycle and cell fate regulatory programs blocks non-genetic cancer evolution in acute lymphoblastic leukemia

Background: Targeted therapies exploiting vulnerabilities of cancer cells hold promise for improving patient outcome and reducing side-effects of chemotherapy. However, efficacy of precision therapies is limited in part because of tumor cell heterogeneity. A better mechanistic understanding of how drug effect is linked to cancer cell state diversity is crucial for identifying effective combination

Associations of psychological factors with atherosclerosis and cardiovascular health in middle-age : the population-based Swedish CArdioPulmonary bioImage study (SCAPIS)

Background: Cardiovascular disease (CVD) is a major global health issue, primarily caused by atherosclerosis. Psychological factors may play a role in the development and progression of CVD. However, the relationship between psychological factors and atherosclerosis is complex and poorly understood. This study, therefore, aimed to examine the association of psychological factors with (i) coronary

Inhibition of aquaporin-9 ameliorates severe acute pancreatitis and associated lung injury by NLRP3 and Nrf2/HO-1 pathways

Inflammation, apoptosis and oxidative stress play crucial roles in the deterioration of severe acute pancreatitis-associated acute respiratory distress syndrome (SAP-ARDS). Unfortunately, despite a high mortality rate of 45 %[1], there are limited treatment options available for ARDS outside of last resort options such as mechanical ventilation and extracorporeal support strategies[2]. This study

Modelling the evaporative cooling effect from methanol injection in the intake of internal combustion engines

Renewable methanol is one of the most promising alternative fuels for internal combustion engines. However, its much higher latent heat of vaporization compared to traditional fossil-based hydrocarbon fuels poses new challenges. On both spark-ignition (SI) engines and dual-fuel (DF) engines, methanol can be introduced through injectors installed in the intake path, with its evaporation then causin

Feasibility of a pioneer social service treatment for gambling disorder—The first 6-month follow-up data

Gambling disorder can be treated with cognitive behavioral therapy (CBT), but treatment is under-dimensioned in many settings. For example, in Sweden, a setting with mixed responsibility for addiction treatment between health care and social services, treatment for gambling disorder has only recently been introduced in the responsibilities of public institutions. After the introduction of gambling

Associations of modifiable and non-modifiable risk factors with cognitive functions – a prospective, population-based, 17 years follow-up study of 3,229 individuals

Background: Although several cardiovascular, demographic, genetic and lifestyle factors have been associated with cognitive function, little is known about what type of cognitive impairment they are associated with. The aim was to examine the associations between different risk factors and future memory and attention/executive functions, and their interaction with APOE genotype. Methods: Participa

Smart real-time evaluation of tunnel fire risk and evacuation safety via computer vision

The distribution of vehicles during a tunnel fire is a crucial factor that affects fire development and hazards, as well as the following evacuation and rescue operations. This work proposed a novel method using computer vision for assessing the real-time tunnel fire risk and evacuation safety by considering the classification and entry flow of vehicles. The proposed system utilizes YOLOv7 and Dee

An observational analysis on the influence of parental allergic rhinitis, asthma and smoking on exhaled nitric oxide in offspring

Background: Parental allergic diseases and smoking influence respiratory disease in the offspring but it is not known whether they influence fractional exhaled nitric oxide (FeNO) in the offspring. We investigated whether parental allergic diseases, parental smoking and FeNO levels in parents were associated with FeNO levels in their offspring. Methods: We studied 609 offspring aged 16–47 years fr

Distance decay effects predominantly shape spider but not carabid community composition in crop fields in north-western Europe

Agricultural intensification and expansion are regarded as main drivers of biodiversity loss. This conclusion is mainly based on observed declines of local diversity (α-diversity), while effects on community composition homogenization (decrease of β-diversity) at a larger spatial scale are less well understood. Carabid beetles and spiders represent two widespread guilds and are important predators

Solving complex problems in emergencies : A Fire and Rescue Service perspective

Syftet med denna licentiatavhandling är att bidra till en ökad förståelse för hurräddningstjänsten kan förbättra sin förmåga att lösa komplexa problem vidstorskaliga olyckshändelser. Större olyckor är ofta komplexa och dynamiskahändelser som kännetecknas av en hög grad av osäkerhet, oförutsägbarhet ochtvetydighet. Under sådana förhållanden utmanas räddningstjänstens förmåga att lösa de olika och mGlobal trends suggest an increasing level of uncertainty regarding potential risks faced by individuals, organizations, or society as a whole. These trends are likely to alter the risk landscape, necessitating the enhancement of societal capabilities to effectively address emerging risks. Among the key actors dealing with such changes is the Fire and Rescue Service (FRS). However, these challenges

Species-specific erosion of genetic diversity in grassland butterflies depends on landscape land cover

Changes in land cover, particularly agricultural intensification, are a primary cause of pollinator decline. Decline and isolation can reduce genetic diversity, reducing adaptive potential and unmasking genetic load. Maintenance of functional connectivity in changing landscapes is necessary to ensure persistence, but how land cover impacts genetic diversity and functional connectivity in butterfli

Effects of time of the day at sampling on CSF and plasma levels of Alzheimer’ disease biomarkers

Background: Studies suggest that cerebrospinal fluid (CSF) levels of amyloid-β (Aβ)42 and Aβ40 present a circadian rhythm. However sustained sampling of large volumes of CSF with indwelling intrathecal catheters used in most of these studies might have affected CSF dynamics and thereby confounded the observed fluctuations in the biomarker levels. Methods: We included 38 individuals with either nor

ITIS-PseKNC : Identification of Translation Initiation Site in human genes using pseudo k-tuple nucleotides composition

Translation is an essential genetic process for understanding the mechanism of gene expression. Due to the large number of protein sequences generated in the post-genomic era, conventional methods are unable to identify Translation Initiation Site (TIS) in human genes timely and accurately. It is thus highly desirable to develop an automatic and accurate computational model for identification of T

Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology

Lewy body (LB) diseases, characterized by the aggregation of misfolded α-synuclein proteins, exhibit notable clinical heterogeneity. This may be due to variations in accumulation patterns of LB neuropathology. Here we apply a data-driven disease progression model to regional neuropathological LB density scores from 814 brain donors with Lewy pathology. We describe three inferred trajectories of LB

Identification of Heat Shock Protein families and J-protein types by incorporating Dipeptide Composition into Chou's general PseAAC

Heat Shock Proteins (HSPs) are the substantial ingredients for cell growth and viability, which are found in all living organisms. HSPs manage the process of folding and unfolding of proteins, the quality of newly synthesized proteins and protecting cellular homeostatic processes from environmental stress. On the basis of functionality, HSPs are categorized into six major families namely: (i) HSP2

Adolescent boys’ experiences of mental health and school health services - an interview study from Norway

Background: Mental health problems among adolescents is a global challenge. During the transition to adolescence, physiological, psychological, and social changes occur, leading to increased vulnerability. Thus, adolescent boys are less likely to seek help for mental health problems, which makes them an undetected group. The aim of this study was to gain a deeper understanding of adolescent boys’