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Molecular mechanisms of Streptococcus dysgalactiae subsp equisimilis enabling intravascular persistence

Streptococcus dysgalactiae subsp. equisimilis (SDSE) can cause recurrent bacteremic infection. We have characterized novel virulence properties of an SDSE isolate of type stG485.0 that caused severe sepsis three times in a patient despite that he had opsonizing antibodies to the isolate. An infected aortic aneurysm was suspected to be the focus for the persisting bacteria. For the first time we sh

Usage of Open Source in Commercial Software Product Development - Findings from a Focus Group Meeting

Open source components can be used as one type of software component in development of commercial software. In development using this type of component, potential open source components must first be identified, then specific components must be selected, and after that selected components should maybe be adapted before they are included in the developed product. A company using open source compone

25-Hydroxyvitamin D and Cardiovascular Disease in Patients With Systemic Lupus Erythematosus: Data From a Large International Inception Cohort

Objective. An association between 25-hydroxyvitamin D (25[ OH] D; vitamin D) deficiency and increased cardiovascular (CV) risk factors and CV disease (CVD) has been shown in general population studies. Vitamin D deficiency has been noted in systemic lupus erythematosus (SLE), and CVD is a major cause of morbidity and mortality in SLE. The objectives of this study were to estimate the associations

Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome

BACKGROUND Men and women with type 1 long QT syndrome (LQT1) exhibit time-dependent differences in the risk for cardiac events. OBJECTIVE We hypothesized that sex-specific risk for LQT1 is related to the location and function of the disease-causing mutation in the KCNQ1 gene. METHODS The risk for life-threatening cardiac events (comprising aborted cardiac arrest [ACA] or sudden cardiac death [SCD]

Prevention of dislocation of the hip in children with cerebral palsy: 20-year results of a population-based prevention programme.

In 1994 a cerebral palsy (CP) register and healthcare programme was established in southern Sweden with the primary aim of preventing dislocation of the hip in these children. The results from the first ten years were published in 2005 and showed a decrease in the incidence of dislocation of the hip, from 8% in a historical control group of 103 children born between 1990 and 1991 to 0.5% in a grou

Underlying event characteristics and their dependence on jet size of charged-particle jet events in pp collisions at root(s)=7 TeV with the ATLAS detector

Distributions sensitive to the underlying event are studied in events containing one or more chargedparticle jets produced in pp collisions at root s = 7 TeV with the ATLAS detector at the Large Hadron Collider (LHC). These measurements reflect 800 mu b(-1) of data taken during 2010. Jets are reconstructed using the anti-k(t) algorithm with radius parameter R varying between 0.2 and 1.0. Distribut

The assessment of vertical daylight factors across the walls of atrium buildings, Part 2: Rectangular atria

This study investigated the impact of well geometry and surface reflectance on vertical daylight factors on the walls of rectangular atria under a CIE standard overcast sky. The vertical daylight factors predicted using the modelling software Radiance were validated by artificial sky scale model measurements. More simulated data of vertical daylight factors for a very wide range of rectangular atr

On the Choice of Test for a Unit Root when the Errors are Conditionally Heteroskedastic

It is well known that in the context of the classical regression model with heteroskedastic errors, while ordinary least squares (OLS) is not efficient, the weighted least squares (WLS) and quasi-maximum likelihood (QML) estimators that utilize the information contained in the heteroskedasticity are. In the context of unit root testing with conditional heteroskedasticity, while intuition suggests

Field ionization of high-Rydberg fragments produced after inner-shell photoexcitation and photoionization of the methane molecule

We have studied the production of neutral high-Rydberg (HR) fragments from the CH4 molecule at the C 1s -> 3p excitation and at the C 1s ionization threshold. Neutral fragments in HR states were ionized using a pulsed electric field and the resulting ions were mass-analyzed using an ion time-of-flight spectrometer. The atomic fragments C(HR) and H(HR) dominated the spectra, but molecular fragments

Dashboard report on performance on select quality indicators to cancer care providers

Objective: Cancer quality registers are attracting increasing attention as important, but still underutilized sources of clinical data. To optimize the use of registers in quality assurance and improvement, data have to be rapidly collected, collated and presented as actionable, at-a-glance information to the reporting departments. This article presents a dashboard performance report on select qua

Derivative backoff: The other saturation problem for PID controllers

tThe PID controller is by far the most common controller, and to ensure good behavior under all circumstances, a PID implementation must consider many practical aspects such as integrator windup,derivative kick, and bumpless parameter and mode changes. In this paper, an entirely new issue for the derivative part is introduced and has been named derivative backoff. It occurs when the process value

Data fusion for reconstruction algorithms via different sensors in geophysical sensing

Abstract in UndeterminedInformation fusion via multimodal inverse problems and different sensors is addressed using a Fisher information analysis approach. The Fisher information measure is inherently additive, and it facilitates an appropriate weighting of the measurement data that is statistically optimal and can hence be useful with reconstruction algorithms in geophysical sensing. Given that t

Acuity and Anxiety From the Patient's Perspective in the Emergency Department.

Knowledge of a patient's perception of her medical needs and urgency may make it possible for emergency nurses to communicate the triage decision and make the patient understand the assessment and triage category. The aim of this study was to compare the patients' own assessments of their acuity to the triage nurse's assessment, as well as describe patient satisfaction and levels of anxiety.

Implementation of robot-assisted gynecologic surgery for patients with low and high BMI in a German gynecological cancer center.

Purpose To present a single center outcome from an initial series of gynecological robotic cases with a special reference to obese patients. Methods A retrospective evaluation of 116 women, undergoing elective gynecologic robot-assisted surgery from February 2011 to December 2012. Procedures included hysterectomy (HE), radical HE, adnexectomy, myomectomy, pelvic lymphadenectomy and paraaortic lymp

The effect of IPS on participants' engagement, quality of life, empowerment, and motivation: a randomized controlled trial.

Abstract Objective: To investigate the effectiveness of Individual Placement and Support (IPS) with regard to non-vocational outcomes among individuals with severe mental illness. Methods: A randomized controlled trial was carried out, comparing IPS with traditional vocational rehabilitation. The Empowerment Scale, the Worker Role Interview, the Profile of Occupational Engagement, and the Manchest

Characterization of volatile components extracted from Vangueria infausta (African medlar) by using GC-MS

Volatile compounds isolated from the African medlar (Vangueria infausta L.) were identified by gas chromatography and gas chromatography-mass spectrometry. The volatile components identified in the extract were: hexanoic acid (5600 mu g/g, dry matter, DM), octanoic acid (240 mu g/g, DM), methyl hexanoate (15 mu g/g, DM), ethyl hexanoate (44 mu g/g, DM), methyl octanoate (12 mu g/g, DM) and ethyl o

Biokinetics Of 18F-Choline Studied In Four Prostate Cancer Patients

Biokinetic data are important when calculating the absorbed dose to the patients and can also be used to find the optimal time between injection and imaging. To the authors' knowledge, there are no published biokinetic data in humans for (18)F-choline, except some distribution data at single time points. Four patients with suspicion of metastases due to biochemical recurrence (measurable prostate-

Autocrine Fibroblast Growth Factor 18 Mediates Dexamethasone-Induced Osteogenic Differentiation of Murine Mesenchymal Stem Cells

The potential of mesenchymal stem cells (MSC) to differentiate into functional bone forming cells provides an important tool for bone regeneration. The identification of factors capable of promoting osteoblast differentiation in MSCs is therefore critical to enhance the osteogenic potential of MSCs. Using microarray analysis combined with biochemical and molecular approach, we found that FGF18, a

The Role of Neuropeptides in Suicidal Behavior: A Systematic Review

There is a growing evidence that neuropeptides may be involved in the pathophysiology of suicidal behavior. A critical review of the literature was conducted to investigate the association between neuropeptides and suicidal behavior. Only articles from peer-reviewed journals were selected for the inclusion in the present review. Twenty-six articles were assessed for eligibility but only 22 studies