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Background: In the COMET study, carvedilol improved survival compared to metoprolol tartrate in 3029 patients with NYHA II-IV heart failure and EF <35%, followed for an average of 58 months. Aims: To evaluate whether the effect on overall mortality was specific for a particular mode of death. This may help to identify the mechanism of the observed difference. Methods: Of the 1112 total deaths, 972
Most foot-propelled swimming birds sweep their webbed feet backwards in a curved path that lies in a plane aligned with the swimming direction. When the foot passes the most outward position, near the beginning of the power stroke, a tangent to the foot trajectory is parallel with the line of swimming and the foot web is perpendicular to it. But later in the stroke the foot takes an increasingly t
Identifying haemophilia patients with inhibitors for clinical trials is difficult due to the limited number of patients available. Registries are therefore being established as an additional means of data collection. The aim of this study was to investigate the effect of different recombinant activated factor VII (rFVIIa; NovoSeven((R))) dose ranges and dosing schedules on the incidence of re-blee
Alpha 1-antitrypsin (A1AT) deficiency, one of the most common inborn errors of metabolism in Caucasians, is characterized by a low serum concentration of A1AT and a high risk of pulmonary emphysema and liver disease. The allelic frequency for the most common protease inhibitor (PI) Z mutation in the SERPINA1 gene is 2-5% in Caucasians of European descent. The objective of our study was to estimate
1. Some models of marine no-take reserves predict that reserves can enhance fishery yield. However, empirical evidence of this remains inconclusive. One reason for this may be the disregard for density-dependent body growth in most models. Density-dependent body growth links the number and size of individuals, and thus could influence the biomass of fishery yield. 2. We developed an age- and size
Mixtures of hydrophobically modified hydroxyethyl cellulose (HMHEC) and alkali-sensitive cleavable betaine ester surfactants have been studied by viscometry, H-1 NMR, absorbance measurements, and birefringence determinations. Before the hydrolysis, the surfactants behaved as conventional nondegradable surfactants in terms of the effect on the viscosity of increasing surfactant concentration. As th
OBJECTIVE: To explore the effects of MgSO4 in combination with glucose, insulin, and potassium (GIK) on intrinsic AV-nodal properties during chronic atrial fibrillation. METHODS: The study included two patient groups--(a) control and intervention and (b) intervention--with different infusion times and concentrations of MgSO4. Ambulatory electrocardiographic recordings were analyzed using modified
The aerosol characterization experiment performed within the Large-Scale Biosphere-Atmosphere Experiment in Amazonia-Smoke, Aerosols, Clouds, Rainfall and Climate (LBA-SMOCC) field experiment carried out in Rondonia, Brazil, in the period from September to November 2002 provides a unique data set of size-resolved chemical composition of boundary layer aerosol over the Amazon Basin from the intense
We have analyzed mantle cell lymphomas (MCLs), using high-density DNA microarrays, and confirmed the expression of differentially regulated antigens, using flow cytometry and immunohistochemistry. The results show that MCLs acquire expression of molecules that normally are involved in interaction with other immune cells and, thus, might affect the ability of the tumor to survive. The MCL signature
Mutations in the three collagen VI genes COL6A1, COL6A2 and COL6A3 cause Bethlem myopathy and Ullrich congenital muscular dystrophy (UCMD). UCMD, a severe disorder characterized by congenital muscle weakness, proximal joint contractures and marked distal joint hyperextensibility, has been considered a recessive condition, and homozygous or compound heterozygous mutations have been defined in COL6A
Objective: The etiology of secretory otitis media (SOM) is multifactorial. The main factors discussed are infection and tuba[ dysfunction. This study aimed to detect poor tuba[ function and tympanic membrane pathology in young adults after extremely long-standing SOM. Methods: Thirty-four patients, 16-25 years old, with previous chronic SOM persisting at least 6 years (mean 11.2 years, range 6.2-1
The LIDAR technique is an efficient tool in monitoring the distribution of atmospheric species of importance. We study the concentration of atmospheric atomic mercury in an Italian geothermal field and discuss the possibility of using recent results from local polynomial kernel regression theory for the evaluation of the derivative of the DIAL curve. A MISE-optimal bandwidth selector, which takes
in vitro models are often used to investigate pathophysiological mechanisms of brain cell injury as they occur for instance during cerebral ischemia. To analyze the efficacy of potential neuroprotective compounds, cell physiological experiments were performed in a recently improved culture system of human model neurons. The postmitotic neurons were generated from the human NT-2 teratocarcinoma cel
Numerous lineages of avian malaria parasites of the genus Plasmodium have been deposited in GenBank. However, only 11 morphospecies of Plasmodium have been linked to these lineages. Such linking is important because it provides opportunities to combine the existing knowledge of traditional parasitology with novel genetic information of these parasites obtained by molecular techniques. This study l
Purpose: A scale assessing primary care physicians' priorities for genetic education (The Gen-EP scale) was developed and tested in five European countries. The objective of this study was to determine its factor structure, to test scaling assumptions and to determine internal consistency. Methods: The sample consisted of 3686 practitioners (general practitioners, gyneco-obstetricians, pediatricia
We present a new approach for the accurate reconstruction of three-dimensional skeletal positions using roentgen single-plane photogrammetric analysis (RSPA). This technique uses a minimum of three markers embedded in each segment which allow continuous, real-time, internal skeletal movement to be measured from single-plane images, provided that the precise distance between the markers is known. A
