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Load and lock: the molecular mechanisms of B-lymphocyte commitment.

Summary: The maturation of B-lymphoid cells from hematopoietic stem cells in the bone marrow is a complex process under control of interplay between extrinsic and intrinsic factors. In addition to serving as a model for normal cell differentiation, disturbances in this process results in immunodeficiencies and malignancies, such as leukemia and lymphoma, making the subject of high relevance for mo

Chromosome 2q12, the ADRA2B I/D polymorphism and metabolic syndrome.

OBJECTIVE: To test whether a previously hypertension-linked 23 cM region on chromosome 2 is linked to the metabolic syndrome (MetS) or its individual components, and whether a common I/D polymorphism of the adrenergic receptor 2b (ADRA2B) gene, mapping in that region, is associated with the same traits. METHODS: We conducted fine mapping of the hypertension-linked region on chromosome 2 spanning b

Arkeologiska liv lästa

A critical review of Jarl Nordbladh (ed), "Arkeologiska liv. Om att leva arkeologiskt" (Archaeological lives: on living as an archaeologist, Göteborg 1995). The book deals with the lives of six Swedish and Danish archaeologists.

Sequelae following sural nerve biopsy in type 1 diabetic subjects.

Objectives - To detect post-operative sequelae of sural nerve biopsy. Materials and methods-- A questionnaire mailed to type 1 diabetic patients (n = 24; male/female 23/1; reply n = 23) 2 years after biopsy. Results - Type 1 diabetic patients (age 56 [11]; median [interquartile range]) had a long duration of diabetes (DM; 20 [19] years) and all had neuropathy. Three out of 24 patients developed in

High-order Harmonics - A Coherent Source In the Xuv Range

We review the main results concerning high-order generation processes from the point of view of a potential user of this new source of XUV radiation. The perspectives for optimizing the source, both in efficiency and in spectral range, its characteristics and in particular, its coherence properties, are discussed. Finally, we describe two experiments, which demonstrate the usefulness of the harmon

Information for better or for worse: interviews with parents when their foetus was found to have choroid plexus cysts at a routine second trimester ultrasound.

The aim of the study was to gain a theoretical understanding of parents' experiences and handling of the situation, when their foetus was diagnosed as having choroid plexus cysts, at a routine second trimester ultrasound examination. Nine couples and one mother were interviewed using one open question. Analysis method was Grounded Theory. The main concern was anxiety and the core category became n

Archaeology, Identity and the Right to Culture. Anthropological perspectives on repatriation

The debate concerning repatriation and reburial has recently earned increasing attention in Sweden. While most archaeologists today understand the importance of repatriation and the arguments underlying the claims, the process is not completely unproblematic, and certainly not in all cases. This article explores some tendencies within the international debate about repatriation and frames them wit

Nonlinear FE Model of the CFRP / Concrete Interface

This paper presents a finite element analysis which is validated against laboratory tests of eight beams strengthened with externally bonded with carbon fibre reinforced plastic (CFRP) plates. The commercial numerical analysis tool Abaqus was used. Cohesive elements were used to model traction and shear behaviour of concrete/CFRP interface. The results are presented and discussed in terms of loadi