Increased apolipoprotein E ε4 in epilepsy with senile plaques
Inheritance of the apolipoprotein E (ApoE) ε4 allele is a risk factor for Alzheimer's disease (AD) and is associated with increased deposition of β-amyloid (Aβ) in AD, Down's syndrome, and normal aging. Aβ deposition in the form of senile plaques (SPs) has recently been described in patients with temporal lobe epilepsy (TLE). We studied the relationship between ApoE ε4 genotype and the deposition