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Influence of the pre-analytical specimen storage conditions on thrombin generation assay
Designing pi-stacked molecular structures to control heat transport through molecular junctions
We propose and analyze a way of using pi stacking to design molecular junctions that either enhance or suppress a phononic heat current, but at the same time remain conductors for an electric current. Such functionality is highly desirable in thermoelectric energy converters, as well as in other electronic components where heat dissipation should be minimized or maximized. We suggest a molecular d
Life-History Differences Favor Evolution of Male Dimorphism in Competitive Games
Many species exhibit two discrete male morphs: fighters and sneakers. Fighters are large and possess weapons but may mature slowly. Sneakers are small and have no weapons but can sneak matings and may mature quickly to start mating earlier in life than fighters. However, how differences in competitive ability and life history interact to determine male morph coexistence has not yet been investigat
Attosecond Electron Spectroscopy Using a Novel Interferometric Pump-Probe Technique
We present an interferometric pump-probe technique for the characterization of attosecond electron wave packets (WPs) that uses a free WP as a reference to measure a bound WP. We demonstrate our method by exciting helium atoms using an attosecond pulse (AP) with a bandwidth centered near the ionization threshold, thus creating both a bound and a free WP simultaneously. After a variable delay, the
Chemical Evolution of the Inner 2 Degrees of the Milky Way Bulge: [α/Fe] Trends and Metallicity Gradients
The structure, formation, and evolution of the Milky Way bulge is a matter of debate. Important diagnostics for discriminating between models of bulge formation and evolution include alpha-abundance trends with metallicity, and spatial abundance and metallicity gradients. Due to the severe optical extinction in the inner Bulge region, only a few detailed investigations of this region have been per
Interactions between semiconductor nanowires and living cells.
Semiconductor nanowires are increasingly used for biological applications and their small dimensions make them a promising tool for sensing and manipulating cells with minimal perturbation. In order to interface cells with nanowires in a controlled fashion, it is essential to understand the interactions between nanowires and living cells. The present paper reviews current progress in the understan
Emerging biomarkers and intervention targets for immune-modulation of atherosclerosis - A review of the experimental evidence.
The role of inflammation in atherosclerosis and plaque vulnerability is well recognized. However, it is only during recent years it has become evident that this inflammation is modulated by immune responses against plaque antigens such as oxidized LDL. Interestingly, both protective and pathogenic immune responses exist and experimental data from animal studies suggest that modulation of these imm
Fibroblast growth factor 10 represses premature cell differentiation during establishment of the intestinal progenitor niche
Spatio-temporal regulation of the balance between cell renewal and cell differentiation is of vital importance for embryonic development and adult homeostasis. Fibroblast growth factor signaling relayed from the mesenchyme to the epithelium is necessary for progenitor maintenance during organogenesis of most endoderm-derived organs, but it is still ambiguous whether the signal is exclusively mitog
Interaction complexity matters: disentangling services and disservices of ant communities driving yield in tropical agroecosystems.
Owing to complex direct and indirect effects, impacts of higher trophic levels on plants is poorly understood. In tropical agroecosystems, ants interact with crop mutualists and antagonists, but little is known about how this integrates into the final ecosystem service, crop yield. We combined ant exclusion and introduction of invasive and native-dominant species in cacao agroecosystems to test wh
Circulation stabilizing therapy and pulmonary high-resolution computed tomography in a porcine brain-dead model.
Currently 80% of donor lungs are not accepted for transplantation, often due to fluid overload. Our aim was to investigate if forced fluid infusion may be replaced by a new pharmacological therapy to stabilize circulation after brain death in an animal model, and to assess therapy effects on lung function and morphology trough blood gas parameters and state-of-the-art High-resolution CT (HRCT).
Effects of Bilberry (Vaccinium myrtillus) in Combination with Lactic Acid Bacteria on Intestinal Oxidative Stress Induced by Ischemia-Reperfusion in Mouse.
Intestinal ischemia-reperfusion (I/R) results in oxidative stress, inflammation, and tissue injuries. The present study investigates the antioxidative and anti-inflammatory effects of a dietary supplement of bilberry, either alone or in combination with Lactobacillus plantarum RESO56, L. plantarum HEAL19, or Pediococcus acidilactici JAM046, in an I/R-induced model for oxidative stress in mice. A b
Genome analysis of Moraxella catarrhalis strain RH4, a Human Respiratory Tract Pathogen.
Moraxella catarrhalis is an emerging human-restricted respiratory tract pathogen that is a common cause of childhood otitis media and exacerbations of chronic obstructive pulmonary disease in adults. Here, we report the first completely assembled and annotated genome sequence of an isolate of M. catarrhalis: strain RH4, originally isolated from blood of an infected patient. The RH4 genome consists
Humanising the Subaltern: Unbounded Caste and the Limits of a Rights Regime
The Power of Knowledge: Learning from 'Learning by Knowledge-Intensive Firm'
P>This article reviews and discusses the contribution of William Starbuck's 'Learning by Knowledge-Intensive Firms'. Apart from situating Starbuck's article in its historical context and contemporary debates it is argued that the concept of esoteric knowledge and the focus on persuasion provides untapped potential for enhancing our understanding of knowledge work and knowledge-intensive firms. In
Prevalence and characteristics of the metabolic syndrome in 2479 hypopituitary patients with adult-onset GH deficiency before GH replacement: a KIMS analysis
Objective: An increased risk of cardiovascular morbidity and mortality in adult GH deficiency (GHD) may be related to hypopituitarism but also to the presence of the metabolic syndrome (MetS). Our objective was to investigate the characteristics and prevalence of MetS as well as its comorbidities in adult GHD. Design: In KIMS (Pfizer International Metabolic Database) 2479 patients with severe adul
Human variome project country nodes: Documenting genetic information within a country
The Human Variome Project (http://www.humanvariomeproject.org) is an international effort aiming to systematically collect and share information on all human genetic variation. The two main pillars of this effort are gene/disease-specific databases and a network of Human Variome Project Country Nodes. The latter are nationwide efforts to document the genomic variation reported within a specific po
Structural abnormalities in atrial walls are associated with presence and persistency of atrial fibrillation but not with age.
OBJECTIVES: The purpose of this study was to assess the association between structural changes in human atria, age, and history of atrial fibrillation (AF). BACKGROUND: Development of fibrosis in atrial walls is associated with deterioration of atrial conduction and predisposes to AF in experiment. Human data, however, are scarce, and whether fibrosis is a cause or consequence of AF is not known.
Cloud condensation nuclei production associated with atmospheric nucleation: a synthesis based on existing literature and new results
This paper synthesizes the available scientific information connecting atmospheric nucleation with subsequent cloud condensation nuclei (CCN) formation. We review both observations and model studies related to this topic, and discuss the potential climatic implications. We conclude that CCN production associated with atmospheric nucleation is both frequent and widespread phenomenon in many types o
Patterns of psychological responses in parents of children that underwent stem cell transplantation
ObjectiveHematopoietic stem cell transplantation (HSCT) is curative in several life-threatening pediatric diseases but may affect children and their families inducing depression, anxiety, burnout symptoms, and post-traumatic stress symptoms, as well as post-traumatic growth (PTG). The aim of this study was to investigate the co-occurrence of different aspects of such responses in parents of childr