You want to run an experiment where you anticipate finding a treatment effect.How large should your sample size be to have a reasonable chance of detectingsignificant results? In this manuscript, I present and explain the Stata code I use toaddress this question. The code uses simulations to conduct power analyses,offering a flexible alternative to the commonly used analytical tools. Unliketraditi

Nitrogenase is the only enzyme that can cleave the strong triple bond in N2, making nitrogen available for biological life. Despite extensive research, the mechanism of nitrogen fixation by nitrogenase is not fully understood, partly due to the enzyme’s complex structure, which includes the largest iron–sulfur cluster known in metalloenzymes, the FeMo cluster. Understanding this process requires t

When treating pregnant women with antiepileptic drugs (AEDs), clinicians have to balance potential fetal adverse effects against the risks of uncontrolled maternal disease. Only recently have emerging scientic data provided a rational basis for treatment decisions considering both aspects. The focus of research is currently moving from the first to the second AED generation. Lamotrigine is relativ

The human silencing hub (HUSH) complex binds to transcripts of LINE-1 retrotransposons (L1s) and other genomic repeats, recruiting MORC2 and other effectors to remodel chromatin. How HUSH and MORC2 operate alongside DNA methylation, a central epigenetic regulator of repeat transcription, remains largely unknown. Here we interrogate this relationship in human neural progenitor cells (hNPCs), a soma

the first presentation of artists Marcus Matt and Samaneh ReyhaniText i utställningskatalog till utställningen: AS IF HERE – Samaneh Reyhani & Marcus Matt på Trelleborgs museer 8 June 2024- 1 September 2024.

Obesity is a known risk factor for development of osteoarthritis (OA). Numerical tools like finite-element (FE) models combined with degenerative algorithms have been developed to understand the interplay between OA and obesity. In this study, we aimed to predict knee cartilage degeneration in a cohort of obese adults to investigate the importance of patient-specific information on degeneration pr

The migration of large populations has had significant importance on historical and contemporary societies. Since mass migration is a multifaceted phenomenon that significantly impacts both places of origin and destination, shaping the lives of those directly and indirectly involved, it has drawn extensive research attention. Much of the economic history literature has focused on the Age of Mass M

A measurement of the Standard Model Higgs boson produced in association with a W or Z boson and decaying into a pair of τ-leptons is presented. This search is based on proton-proton collision data collected at s=13 TeV by the ATLAS experiment at the LHC corresponding to an integrated luminosity of 140 fb−1. For the Higgs boson candidate, only final states with at least one τ-lepton decaying hadron

Denna studie tar avstamp i den tudelade akademiska debatten kring vilka potentialer och fallgropar det finns för tillfällig användning av stadens mellanrum, och har syftat till att undersöka hur Institut for (x) har lyckats upprätthålla sin tillfälliga användning av Godsbanearealerne i Aarhus över en längre tidsperiod. Genom intervjuer med representanter för Institut for (x) och Aarhus kommun, harAgainst the backdrop of a divided academic debate on the potentials and pitfalls for temporary use of urban space, this essay aims to explore how Institut for (x) as a temporary use project has been able to maintain their use of Godsbanearealerne in Aarhus over a longer period of time. This has been done through interviews with representatives of Institut for (x) and Aarhus municipality, where the

This paper aims to explore how four Bolivian small and medium-sized enterprises’ business has overcome the gaps in reliance on traditional small and medium-sized enterprises’ business models, i.e., to extract and sell raw unrefined natural resources in a local area, and instead make productive use of innovation inputs (technology, higher-educated people) by innovating their business models. We wer

Bakgrunn.I Norge blir det hvert år analysert hundretusener av urinprøver for å påvise inntak av rusmidler og legemidler med ruspotensial. Ved Avdeling for klinisk farmakologi ved St. Olavs hospital analyseres årlig rundt 60 000 urinprøver for rusmidler og legemidler med ruspotensial. Vi ønsket å finne ut om vårt standard analysepanel avdekker de fleste.Materiale og metode.Alle urinprøver mottatt i

Efficient prevention of adverse drug reactions (ADRs) requires knowledge about their severity and pharmacological mechanisms and is dependent on reliable data on their frequencies and possible risk factors. The study was conducted to investigate the prescribers' experience and understanding of the ADRs of psychotropic drugs, and their attitude towards reporting these. In a questionnaire, physician

Bakgrunn.I 2007 kom det anbefalinger om at serumkonsentrasjonen av digitoksin bør ligge i området 8 – 15 nmol/l, noe som er ca. halvparten av det som tidligere var ansett som optimalt, og forslag til nye doseringsrutiner.Materiale og metode.Utviklingen for angitt dosering og serumkonsentrasjoner av digitoksin er undersøkt med utgangspunkt i 13 054 prøver sendt til Avdeling for klinisk farmakologi

After common belief the impairment of nerve conduction seen with multiple sclerosis has to do with uncovering of internodal potassium channels. Therefore, suitable potassium channel blockers like 5-methoxypsoralen can alleviate functional deficits due to multiple sclerosis. This has been demonstrated by single tests under well-defined laboratory conditions and by further clinical single trials. Wi

The effects of myoglobin on renal microcirculation were studied in anesthetized rats subjected to hemorrhagic hypotension. Capillary flow distribution was determined by allowing two dyes to circulate for 3 and 1 min, respectively, freezing the left kidney and quantifying the dye distribution in histological sections by analyzing the distances of regularly spaced test points to the next dye-labeled

Depression is common during pregnancy, and a considerable proportion of pregnant women take antidepressants. Modern antidepressants (e.g. SSRIs) are fairly safe to use during pregnancy. Several physiological changes occur in the pregnant state, possibly affecting the pharmacokinetics of many drugs. Metabolism via CYP enzymes are important for the elimination of antidepressants. This metabolism mayDepression is common during pregnancy, and a considerable proportion of pregnant women take antidepressants. Modern antidepressants (e.g. SSRIs) are fairly safe to use during pregnancy. Several physiological changes occur in the pregnant state, possibly affecting the pharmacokinetics of many drugs. Metabolism via CYP enzymes are important for the elimination of antidepressants. This metabolism may