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The impact of age on survival of diffuse large B-cell lymphoma - a population-based study

Background. For Diffuse large B-cell lymphoma (DLBCL), the International Prognostic Index is the major tool for prognostication and considers an age above 60 years as a risk factor. However, there are several indications that increasing age is associated with more biological complexity, resulting in differences in DLBCL biology depending on age. Methods. We conducted a registry-based retrospective

Fractional excretion of IgG in idiopathic membranous nephropathy with nephrotic syndrome: a predictive marker of risk and drug responsiveness.

BACKGROUND: Treatment of idiopathic membranous nephropathy with nephrotic syndrome is still controversial. There is currently little known about the clinical use of renal biomarkers which may explain contradictory results obtained from clinical trials. In order to assess whether IgG-uria can predict the outcome in membranous nephropathy, we examined the value of baseline EF-IgG in predicting remis

Using eye-tracking to trace a cognitive process: Gaze behavior during decision making in a natural environment

The visual behaviour of consumers buying (or searching for) products in a supermarket was measured and used to analyse the stages of their decision process. Traditionally metrics used to trace decision-making processes are difficult to use in natural environments that often contain many options and unstructured information. Unlike previous attempts in this direction (i.e. Russo & Leclerc, 1994

Educational applications of the SST framework

This paper is the fourth in a series discussing experiences in applying the Strategic Systemic Thinking (SST) framework. The framework was originally proposed for the purpose of supporting contextual analysis into complex problem spaces as part of information systems analysis. Previous papers have dealt with an application supporting strategic development of work in an academic university departme

Retinopathy in subjects with pre-diabetes and electrophysiological studies in diabetes patients with and without retinopathy

Diabetes is increasing worldwide and hence the risk developing complications where retinopathy is the theme of this study. The aim of the study was to evaluate the presence of (vascular) retinopathy in subjects with the pre-diabetes stage, impaired fasting glucose (IFG), and the development of retinopathy in these subjects during five years. In the second part of the study diabetes patients with d

Enhancement of fermentable sugar yield by competitive adsorption of non-enzymatic substances from yeast and cellulase on lignin

Background: Enhancement of enzymatic digestibility by some supplementations could reduce enzyme loading and cost, which is still too high to realize economical production of lignocellulosic biofuels. A recent study indicates that yeast hydrolysates (YH) have improved the efficiency of cellulases on digestibility of furfural residues (FR). In the current work, the components of YH were separated by

Synthesis, structure and interactions with DNA of novel tetranuclear, [Mn-4(II/II/II/IV)] mixed valence complexes

Reaction of Mn(II) with phenoxyalkanoic acids and di-2-pyridyl ketone oxime (Hpko) leads to neutral tetranuclear complexes of the general formula Mn-4(O)(pko)(4)(phenoxyalkanoato)(4) (phenoxyalkanoic acids: H-mcpa = 2-methyl-4-chloro-phenoxy-acetic acid, H-2,4,5-T = 2,4.5-trichloro-phenoxy-acetic acid or H3,4-D = 3,4-dichloro-phenoxy-acetic acid). The compounds were synthesized by adding di2-pyrid

Hyperfine characterization and spin coherence lifetime extension in Pr3+:La-2(WO4)(3)

Rare-earth ions in dielectric crystals are interesting candidates for storing quantum states of photons. A limiting factor on the optical density and thus the conversion efficiency is the distortion introduced in the crystal by doping elements of one type into a crystal matrix of another type. Here we investigate the system Pr3+:La-2(WO4)(3), where the similarity of the ionic radii of Pr and La mi

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocytes and 20 % non-parenchymal cells, the latter being involved in a secondary phase that may dramatically aggravate the initial damage. Hepatotoxicity, a

Rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of Parkinson's disease.

Impaired olfaction is an early pre-motor symptom of Parkinson's disease. The neuropathology underlying olfactory dysfunction in Parkinson's disease is unknown, however α-synuclein accumulation/aggregation and altered neurogenesis might play a role. We characterized olfactory deficits in a transgenic mouse model of Parkinson's disease expressing human wild-type α-synuclein under the control of the

Pooled Panel Unit Root Tests and the Effect of Past Initialization

This paper analyzes the role of initialization when testing for a unit root in panel data, an issue that has received surprisingly little attention in the literature. In fact, most studies assume that the initial value is either zero or bounded. As a response to this, the current paper considers a model in which the initialization is in the past, which is shown to have several distinctive features

Laser absorption spectroscopy of water vapor confined in nanoporous alumina: wall collision line broadening and gas diffusion dynamics.

We demonstrate high-resolution tunable diode laser absorption spectroscopy (TDLAS) of water vapor confined in nanoporous alumina. Strong multiple light scattering results in long photon pathlengths (1 m through a 6 mm sample). We report on strong line broadening due to frequent wall collisions (gas-surface interactions). For the water vapor line at 935.685 nm, the HWHM of confined molecules are ab

Bio-based 3-hydroxypropionic- and acrylic acid production from biodiesel glycerol via integrated microbial and chemical catalysis

Background 3-Hydroxypropionic acid (3HP) and acrylic acid (AA) are industrially important platform- and secondary chemical, respectively. Their production from renewable resources by environment-friendly processes is desirable. In the present study, both chemicals were almost quantitatively produced from biodiesel-derived glycerol by an integrated process involving microbial and chemical catalysis

Missiological developments from Edinburgh 1910 to Today

Critical evaluation of the World Missionary Conference, Edinburgh 1910, from the perspective of later 20th century developments in Christian mission and ecumenism, with special attention to the global South and postcolonial analysis.

Mothers' representations of caregiving and their adult children's representations of attachment: Intergenerational concordance and relations to beliefs about mothering.

Mothers (N= 35) and their adult children completed questionnaires and were interviewed in order to examine relationships between mothers' caregiving representations and their adult children's attachment representations, and relationships between attachment/caregiving representations and beliefs about mothering. Mothers' and their children's accounts of and present thinking about their past relatio

Utilization of prey-rich patches leads to reproductive advantages for clustered individuals of a web-building spider

The ideal free distribution (IFD) model predicts that consumers match the distribution of resources across habitat patches and that this association should lead to equal individual fitness among individuals in a population. Here we studied to what extent predators utilize different prey groups and if the resulting spatial patterns relate to the reproductive success of individuals in a population o

Burchnall-Chaundy Theory for Ore Extensions

We begin by reviewing a classical result on the algebraic dependence of commuting elements in the Weyl algebra. We proceed by describing generalizations of this result to various classes of Ore extensions, including both results that are already known and one new result.