Cell culture models were used to study the effects of long-term ethanol exposure on neuronal cells. Effects on phospholipase C and phospholipase D mediated signal transduction were investigated by assaying receptor-binding, G protein function, activities of lipases, formation of second messengers and c-fos mRNA. The signal transduction cascades displayed abnormal activities from 2 to 7 days of exp

Ground-based FTIR-measurements have been performed at the NDSC (Network for Detection of Stratospheric Change) station on Spitsbergen ((79)degrees N, 12 degrees E). We have investigated several well isolated absorption lines of isotopically heavy O-3 in the 10 mu m region that allowed us to quantify their natural abundances in the arctic atmosphere for the period April 1994 to August 1995, On the

In Sweden application of granulated wood ash has been suggested as a method to supplement nutrient loss resulting from harvesting of forest residues for bioenergy production. Mycelia of two ectomycorrhizal fungi Piloderma sp.I and Ha-96-3. were commonly found to colonise ash granules in a wood ash fertilised spruce forest. Thirty-eight fungal isolates were selected from 10 taxa to investigate the

With material from a Swedish study of the utilization of social research in city welfare agencies, the authors advocate a sociological analysis of the utilization contexts where use of research takes place. The bases of compliance in the organization and the position of the agencies in regard to conflicts in social welfare politics are shown to have great importance for the way organizations use a

High-voltage outdoor insulators made from silicone rubber are sometimes reported to be colonised by microorganisms. When the hydrophobic polymeric surface is covered by a hydrophilic biofilm, the electrical properties of the insulator are altered. In this work, mixed biofilms, similar to those formed on the surfaces of polymeric insulators in the field, were successfully grown on five types of sil

This study aimed to compare the duration of protection against exercise-induced bronchoconstriction (EIB) after inhalation of formoterol (Oxis) Turbuhaler with that of terbutaline Turbuhaler and placebo Turbuhaler in asthmatic patients treated regularly with formoterol Turbuhaler 9 microg b.i.d. and inhaled steroids. The study. performed at three centres (Goteborg and Lund, Sweden, and Trondheim,

Purpose: Bladder outlet obstruction leads to bladder enlargement and subsequent decreases in contractile function in vivo and in vitro. We determined whether there were regional differences in bladder wall properties and in vitro contractile responses after 2 weeks of bladder outlet obstruction. Materials and Methods: Male rabbits underwent cystometry. The bladder was then filled to 40 ml. and the

Aims To describe clinical and demographic characteristics at baseline of a European cohort of adults with congenital heart disease (CHD) and to assess mortality and morbidity in a 5 year follow-up period. Methods and results Data collected as part of the Euro Heart Survey on adult CHD was analysed. This entailed information transcribed from the files of 4110 patients diagnosed with one of eight co

Xenopus oocytes devoid of their follicular enclosure provide a frequently used expression system for investigating receptors that transduce through activation of adenylyl cyclase following injection of the appropriate mRNA. However, due to a low basal activity of the cyclase they cannot be utilized to investigate receptor-mediated reductions in endogenous cAMP levels. In order to overcome this lim