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SLUSH peptides of the PSMβ family enable Staphylococcus lugdunensis to use erythrocytes as a sole source of nutrient iron

During infection, the host employs nutritional immunity to restrict access to iron. Staphylococcus lugdunensis has been recognized for its ability to utilize host-derived heme to overcome iron restriction. However, the mechanism behind this process involves the release of hemoglobin from erythrocytes, and the hemolytic factors of S. lugdunensis remain poorly understood. S. lugdunensis encodes four

Global increase in the optimal temperature for the productivity of terrestrial ecosystems

Vegetation growth may adapt to climate warming by adjusting the relationship between photosynthetic capacity and temperature. However, changes in the optimal temperature for ecosystem productivity during recent decades of warming remain uncertain. Here we provide empirical evidence that global optimal temperature increased at a rate of 0.017 ± 0.002 °C y−1 from 1982 to 2016, using multiple dataset

Cubosomes and hexosomes stabilized by sorbitan monooleate as biocompatible nanoplatforms against skin metastatic human melanoma

Nanoparticles have become versatile assets in the medical field, providing notable benefits across diverse medical arenas including controlled drug delivery, imaging, and immunological assays. Among these, non-lamellar lipid nanoparticles, notably cubosomes and hexosomes, showcase remarkable biocompatibility and stability, rendering them as optimal choices for theranostic applications. Particularl

Projected future changes in the cryosphere and hydrology of a mountainous catchment in the upper Heihe River, China

Climate warming exacerbates the degradation of the mountain cryosphere, including glacier retreat, permafrost degradation, and snow cover reduction. These changes dramatically alter the local and downstream hydrological regime, posing significant threats to basin-scale water resource management and sustainable development. However, this issue is still not adequately addressed, particularly in moun

Advances in the design and delivery of RNA vaccines for infectious diseases

RNA medicines represent a paradigm shift in treatment and prevention of critical diseases of global significance, e.g., infectious diseases. The highly successful messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were developed at record speed during the coronavirus disease 2019 pandemic. A consequence of this is exceptionally shortened vaccine deve

SGLT2 inhibitors for patients with type 2 diabetes mellitus after myocardial infarction : a nationwide observation registry study from SWEDEHEART

Background: Sodium-glucose co-transporter 2 (SGLT2) inhibitors have been shown to reduce rates of heart failure hospitalisations and cardiovascular death in patients with type 2 diabetes and prior cardiovascular disease. We hypothesised that SGLT2 inhibitors could provide cardiovascular benefits in the post-myocardial infarction setting. We aimed to investigate cardiovascular outcomes of SGLT2 inh

Make Modern Microbiology Matter More in the 2023 European Society of Cardiology Guidelines for the Management of Infective Endocarditis

The European Society of Cardiology (ESC) 2023 guidelines for the management of infective endocarditis (IE) stress that a multidisciplinary approach is needed to manage patients with IE. In our view, the guidelines do not include the relevant perspectives from modern microbiology. The diagnostic criteria for IE were changed in the ESC 2023 guidelines, and many IE-causing pathogens are either not cl

Cluster-Based BERTopic Modeling on Swedish COVID-19 Vaccine Posts

This paper explores the prevalent themes across multiple threads on the popular Swedish discussion forum Flashback. Among its diverse array of topics, the forum actively engages users in addressing and debating questions pertaining to COVID-19 vaccines and vaccination. Through distinguishing between positive and negative perspectives within posts across 14 relevant thread discussions, we employ BE

Ruthenium isotopes show the Chicxulub impactor was a carbonaceous-type asteroid

An impact at Chicxulub, Mexico, occurred 66 million years ago, producing a global stratigraphic layer that marks the boundary between the Cretaceous and Paleogene eras. That layer contains elevated concentrations of platinum-group elements, including ruthenium. We measured ruthenium isotopes in samples taken from three Cretaceous-Paleogene boundary sites, five other impacts that occurred between 3

Modified Neumann–Neumann methods for semi- and quasilinear elliptic equations

The Neumann–Neumann method is a commonly employed domain decomposition method for linear elliptic equations. However, the method exhibits slow convergence when applied to semilinear equations and does not seem to converge at all for certain quasilinear equations. We therefore propose two modified Neumann–Neumann methods that have better convergence properties and require fewer computations. We pro

Decontamination of patient bathroom surfaces with 405 nm violet-blue light irradiation in a real-life setting

Background: Irradiation with violet-blue light (VBL), in the spectrum of 405–450 nm, has been reported to be effective against pathogenic bacteria. Aim: To investigate whether VBL irradiation could reduce the level of surface contamination at seven shared patient bathrooms in two wards at a hospital in Sweden. Methods: Repeated sampling of five separate surfaces (door handle, tap water handle, flo

Racial capitalism's role in mitigation deterrence from carbon removal

Two major sociopolitical challenges loom over the development of carbon removal. One is mitigation deterrence: that research and deployment of carbon removal could delay mitigation efforts. The other is environmental and climate justice — in particular that carbon removal will be developed in ways that further environmental racism, e.g. for the benefit of interests and groups in the global North w

How a population-based cohort of men estimate lifetime risk of prostate cancer in a survey before entering a prostate cancer screening trial in Sweden?

Objectives Investigating men's perceived lifetime risk of prostate cancer. Design Survey-based study to men invited for prostate-specific antigen (PSA) screening in the GÖTEBORG-2 trial between September 2015 and June 2020. Setting 38 775 men in the Gothenburg area, Sweden, were invited for PSA-Testing and participated in a survey. Participants 17 980 men participated in PSA-Testing, of whom 13 18

Tibial Baseplate Migration Is Not Associated with Change in Patient-Reported Outcome Measures and Clinical Scores after TKA : A Secondary Analysis of 5 Radiostereometric Analysis Studies with 10-Year Follow-up

Background: Radiostereometric analysis (RSA) provides highly accurate data about the migration of a total knee arthroplasty (TKA) component. However, patient-reported outcome measures (PROMs) reflect the patients' perspective of their functional status, pain, and overall health after TKA. The aim of this study was to evaluate the association between tibial implant migration and change in postopera

AlphaFold-SFA : Accelerated sampling of cryptic pocket opening, protein-ligand binding and allostery by AlphaFold, slow feature analysis and metadynamics

Sampling rare events in proteins is crucial for comprehending complex phenomena like cryptic pocket opening, where transient structural changes expose new binding sites. Understanding these rare events also sheds light on protein-ligand binding and allosteric communications, where distant site interactions influence protein function. Traditional unbiased molecular dynamics simulations often fail t

A GEOMETRIC APPROACH TO APPROXIMATING THE LIMIT SET OF EIGENVALUES FOR BANDED TOEPLITZ MATRICES

This article is about finding the limit set for banded Toeplitz matrices. Our main result is a new approach to approximate the limit set Λ(b), where b is the symbol of the banded Toeplitz matrix. The new approach is geometrical and based on the formula Λ(b) = ∩ρ∊(0, ∞) sp T (bρ), where ρ is a scaling factor, i.e., bρ(t):= b(ρt), and sp(∙) denotes the spectrum. We show that the full intersection ca

Electron-Poor Iridium Pincer Complexes as Dehydrogenation Catalysts : Investigations into Deactivation through Formation of N2, CO, and Hydride Complexes

A range of derivatives of an iridium pincer complex with a bis-trifluoromethyl-substituted ligand have been studied to determine how their properties differ from those of similar systems. The emphasis is on derivatives valuable for catalytic acceptorless dehydrogenation, including intermediates and deactivation products. The studies highlight small but important differences in the electron richnes