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This thesis deals with experimental tests and methods for strength analysis of glulam beams with holes. Test results and methods for strength analysis available in literature are compiled and discussed. The methods considered comprise both code strength design methods and more general methods for strength analysis. New strength tests of beams with quadratic holes with rounded corners are presente

Malignant fibrous histiocytoma (MFH) and fibrosarcoma (FS) of bone are rare malignant tumours and contentious entities. Sixty seven cases labelled as bone MFH (57) and bone FS (10) were retrieved from five bone tumour referral centres and reviewed to determine whether recent advances allowed for reclassification and identification of histological subgroups with distinct clinical behaviour. A panel

The problems of allocation of scarce resources and priority setting in health care have so far not been much studied in the context of stem cell-based therapeutic applications. If and when competitive cost-effective stem cell-based therapies are available, the problem of priority setting - to whom should stem cell-based therapies be offered and on what grounds - is discussed in this article using

The purpose of this project was to investigate the possibilities to manufacture wet-glued laminated beams for load bearing applications from Norway spruce side board lamellae and by that achieve products that are difficult to obtain from the centre yield of a log and also contribute to increased profitability in the sawmill industry.

Properties such as shape stability, strength an

Contributions of vibrationrotation interaction to line intensities of pure rotational coherent anti-Stokes Raman scattering (CARS) of oxygen are here considered in the perspective of what was remarked by us recently for nitrogen. The interaction is conventionally evaluated by means of the so-called HermanWallis (HW) factor, the need of which is conceptually clear but the theoretical expression is

Popular Abstract in Swedish Läkemedelsanvändning är en av sjukvårdens viktigaste behandlingsmetoder för att bota och lindra sjukdom. Samtidigt kan läkemedelsanvändning innebära risker. Det finns en risk för att patienterna får biverkningar av sina läkemedel, att läkemedlen fungerar mindre bra tillsammans och att effekten därmed upphör eller förstärks. Vidare finns det risk för att läkemedlen inte Background: There are differences in drug use depending on non-medical factors such as age, gender and socioeconomic status. The combined effect of these factors, with adjustment for multimorbidity, is highly relevant to study to ensure equality in drug use. Objectives: 1. To examine drug use related to age, gender, income and education after adjustment for multimorbidity, in an entire adult popul

Atypical hemolytic uremic syndrome (aHUS) emerged during the last decade as a disease largely of complement dysregulation. This advance facilitated the development of novel, rational treatment options targeting terminal complement activation, e.g., using an anti-C5 antibody (eculizumab). We review treatment and patient management issues related to this therapeutic approach. We present consensus cl

The decay chain of Fm-246 has been investigated employing the SHIP separator at GSI Darmstadt. The Fm-246 nuclei were produced via the Ar-40(Pb-208, 2n)Fm-246 fusion-evaporation reaction. Improved values of the half-life, T-1/2 = 1.54(4) s, and of the spontaneous fission branching ratio, b(SF) = 0.068(6), of Fm-246 were obtained. The beta(+)/electron capture branching ratio, b(EC) = 0.39(3), of Cf

This Letter reports a measurement of the high-mass Drell-Yan differential cross-section in proton-proton collisions at a centre-of-mass energy of 7 TeV at the LHC. Based on an integrated luminosity of 4.9 fb(-1), the differential cross-section in the Z/gamma* -> e(+)e(-) channel is measured with the ATLAS detector as a function of the invariant mass, m(ee), in the range 116 < m(ee) < 1500 GeV, for

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerdiagnosen hos kvinnor, och under år 2011 fick över 8000 svenska kvinnor denna diagnos. Termen bröstcancer är egentligen ett samlingsnamn för alla de olika typer av cancer som kan uppstå i bröstet. En del typer av bröstcancer har en bra prognos medan andra trots aggressiv behandling alltjämt har en dålig prognos. Cancer är en sjukdom dBreast cancer is a heterogenous disease which can be divided in subgroups of distinct biology with disparate prognosis and response to treatment. The overall aim of this thesis was to delineate subgroup specific behaviour in breast cancer cells with focus on proliferation, migration and stem-like cell activity. In addition, we have studied the functional retinoblastoma tumour suppressor (RB) prote

Background: Earlier analyses within the EPIC study showed that dietary fibre intake was inversely associated with colorectal cancer risk, but results from some large cohort studies do not support this finding. We explored whether the association remained after longer follow-up with a near threefold increase in colorectal cancer cases, and if the association varied by gender and tumour location. Me

Objectives High-risk human papillomavirus (hrHPV) is the primary cause of cervical cancer. As Chlamydia trachomatis is also linked to cervical cancer, its role as a potential co-factor in the development of cervical intraepithelial neoplasia (CIN) grade 2 or higher was examined. Methods The placebo arms of two large, multinational, clinical trials of an HPV6/11/16/18 vaccine were combined. A total

Objective: To determine the validity of 15 standardized instruments frequently used to measure the outcome of chronic arthritis treatment. Methods: Analyses were performed on data collected at a rehabilitation programme (n=216). The outcome measures evaluated were health-related quality of life, global health, pain, physical function and aerobic capacity. The instrument items were linked to the In

OBJECTIVES: Questions regarding the cell source and mechanisms in the initiation and progression of prostate cancer are today still open for debate. Indeed, our knowledge regarding prostate cell regulation, self-renewal, and cytodifferentiation is presently rather limited. In this study, we investigated these processes in the normal adult human prostate. METHODS: Dynamic expression patterns in pro

Selective immunoglobulin A deficiency is the most common primary immunodeficiency disorder that is strongly overrepresented among patients with celiac disease (CD). IgG antibodies against tissue transglutaminase (tTG) and deamidated gliadin peptides (DGP) serve as serological markers for CD in IgA deficient individuals, although the diagnostic value remains uncertain. The aim of this study was to

The scholarly literature on innovation was for a long time not very voluminous. But as shown in the paper, this is now rapidly changing. New journals, professional associations and organizational units within universities focusing on innovation have also been formed. This paper explores the cognitive and organizational characteristics of this emerging field of social science and considers its pros

Optical and micro-physical features of aerosol are reported using Skyradiometer (POM-01L, Prede, Japan) observations taken from a high-altitude station Merak, located in north-eastern Ladakh of the western trans-Himalayas region during January 2011 to December 2013. The observed daily mean aerosol optical depth (AOD, at 500 nm) at the site varied from 0.01 to 0.14. However, 75 % of the observed AO