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Laminins are alphabetagamma heterotrimeric extracellular proteins that regulate cellular functions by adhesion to integrin and nonintegrin receptors. Laminins containing alpha4 and alpha5 chains are expressed in bone marrow, but their interactions with hematopoietic progenitors are unknown. We studied human bone marrow cell adhesion to laminin-10/11 (alpha5beta1gamma1/alpha5beta2gamma1), laminin-8
Non-word repetition has, not without controversy, been considered a reliable index of phonological memory in children with language impairment (LI). Recent studies do, however, emphasize the strong link between non-word repetition skills and phonological output in pre-school children with LI. The purpose of the present study was to explore the relationship between non-word repetition and different
In this article, we present the second case of a tongue carcinoma with distinct morphological similarities to a primary sclerosing sweat duct carcinoma of the skin. The tumor infiltrated deeply into the striated muscle and exhibited extensive peri- and intraneural growth. Neoplastic cells had mildly pleomorphic nuclei and displayed in addition to small cysts, distinct duct formation with a bilayer
Carbon monoxide (CO), carbon dioxide (CO2), and radiocarbon (14CO2) measurements have been made in Heidelberg from 2001 to 2004 in order to determine the regional fossil fuel CO2 component and to investigate the application of CO as a quantitative tracer for fossil fuel CO2 (CO2(foss)). The observations were compared with model estimates simulated with the regional transport model REMO at 0.5° × 0
Objective. This study was undertaken to investigate the previously reported association of the STAT4 polymorphism rs7574865 with rheumatoid arthritis (RA) in 3 different European populations from Spain, Sweden, and The Netherlands, comprising a total of 2,072 patients and 2,474 controls. Methods. Three different cohorts were included in the study: 923 RA patients and 1,296 healthy controls from Sp
In this paper we prove the local existence of complex-valued harmonic morphisms from any compact semisimple Lie group and their non-compact duals. These include all Riemannian symmetric spaces of types II and IV. We produce a variety of concrete harmonic morphisms from the classical compact simple Lie groups SO(n), SU(n), Sp(n) and globally defined solutions on their non-compact duals SO(n, C)/SO(
Inhibition of dipeptidyl peptidase-4 (DPP-4) is currently explored as a novel therapy of type 2 diabetes. The strategy has been shown to improve glycemia in most, but not all, rodent forms of glucose intolerance. In this study, we explored the effects of DPP-4 inhibition in mice with [beta-cell overexpression of human islet amyloid polypeptide (IAPP). We therefore administered the orally active an
Ectomycorrhizal mycelial systems were grown in unsterile soil using specially designed growth chambers, and the respiratory activity of the mycelium was measured before and after its excision from the host roots. Approximately 30% of the total respiration in the intact system was attributable to the mycorrhizal mycelium in the soil. Severance of mycelial connections at the roots lead to a greater
The aim of this study was to assess the role of videofluoroscopy in the detection of structural abnormalities of the pharynx and esophagus in patients with different symptoms of impaired deglutition. Dynamic radiographic recording of deglutition was performed in 3193 consecutive patients (1578 men, 1615 women; mean age 54 years) suffering from dysphagia, suspicion of aspiration, globus sensation,
We consider propagation models that describe the spreading of an attribute, called “damage,” through the nodes of a random network. In some systems, the average fraction of nodes that remain undamaged vanishes in the large system limit, a phenomenon we refer to as exhaustive percolation. We derive scaling law exponents and exact results for the distribution of the number of undamaged nodes, valid
ventilation/perfusion scintigraphy (V/P-SCAN) was the procedure of choice for studying patients with suspected pulmonary embolism (PE) until the prospective evaluation of V/P imaging in the study known as PIOPED I revealed high number of non diagnostic findings. This has challenged development of computed tomography (CT) during 1990s. Since beginning of 2000, multidetector CT (MDCT) is widely appl
Optical pump-terahertz probe spectroscopy has become a widely used experimental tool for the investigation of the ultrafast far-infrared response of polar systems. In this paper the authors present an analytical method of calculating the propagation of ultrashort terahertz pulses in photoexcited media. The transient terahertz wave form transmitted through the sample is equal to a product of the in
The aggregating proteoglycans (aggrecan, versican, neurocan, and brevican) are important components of many extracellular matrices. Their N-terminal globular domain binds to hyaluronan, but the function of their C-terminal region containing a C-type lectin domain is less clear. We now report that a 90-kDa protein copurifies with recombinant lectin domains from aggrecan and versican, but not from t
Antisocial personality disorder (ASPD) is one of the most common co-occurring disorders in substance abusers, characterized among other things by a high propensity for criminal actions. A cohort of 125 substance abusers were followed in a longitudinal design. Patients were diagnosed with ASPD at an index treatment episode, interviewed at five-year follow-up, and followed-up through the Swedish cri
Aqueous mixtures of oppositely charged polyelectrolytes undergo associative phase separation, resulting in coacervation, gelation, or precipitation. This phenomenon has been exploited in forming DNA gel particles by interfacial diffusion. We report here the formation of DNA gel particles by mixing solutions of double-stranded DNA with aqueous solutions containing two cationic proteins, lysozyme an
Background: Osteocalcin (OC) is produced by osteoblasts during bone formation, and circulating OC has been used in clinical investigations as a marker of bone metabolism. OC is excreted into urine by glomerular filtration and can be found in urine as midmolecule fragments. Methods: We developed and evaluated three immunoassays (U-MidOC, U-LongOC, and U-TotalOC) for the detection of various molecul
Objectives: The antibacterial activity of antimicrobial peptides is influenced by various factors such as salt content, pH and the presence of proteins. In this study, we explored the antibacterial action of the human cathelicidin LL-37 in physiologically relevant conditions, i.e. various human wound fluids, human plasma fractions and serum. Methods: Radial diffusion assays using Staphylococcus au
