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Evaluation of the effects of DBS in the caudal Zona incerta on brain activity during a working memory task in patients with essential tremor

Essential tremor (ET) is characterized by bilateral upper limb postural and/or kinetic tremor, but also cognitive deficits. Tremor in ET, as well as aspects of cognitive deficits associated with ET, have been suggested to be linked to dysfunction in the cerebello-thalamo-cerebral circuit. In ET patients with disabling and medically intractable motor symptoms, Deep Brain Stimulation (DBS) is effect

A cryptically diverse microbial community drives organic matter decomposition in forests

Despite the critical role of microorganisms in plant and fungal residue decomposition, our understanding of their full diversity remains limited. This is due largely to the rapid microbial succession during decomposition, a scarcity of studies including multiple sampling times, and the omission of a species richness index encompassing all decay stages. To address these gaps, we conducted a meta-an

All else equal : Examining treatment bias and stereotypes based on patient ethnicity and socioeconomic status using in-hospital cardiac arrest clinical vignettes

Background: Research on ethnic and socioeconomic treatment differences following in-hospital cardiac arrest (IHCA) largely draws on register data. Due to the correlational nature of such data, it cannot be concluded whether detected differences reflect treatment bias/discrimination – whereby otherwise identical patients are treated differently solely due to sociodemographic factors. To be able to

Association of depression with incident sarcopenia and modified effect from healthy lifestyle : The first longitudinal evidence from the CHARLS

Background: The prospective association of depression with incident sarcopenia remains unknown, as does whether such an association is modified by a healthy lifestyle. Thus, the goal of this study was to determine whether depression is independently related to the risk of developing sarcopenia and to detect the effect of a healthy lifestyle on its modification. Methods: The prospective study inclu

Fish communities and diversity in river ecosystems on the Qinghai-Tibet Plateau revealed by environmental DNA (eDNA) method

The Qinghai-Tibet Plateau (QTP) serves as the source of many large rivers in Asia, and also serves as a natural habitat for rare wildlife and a genetic reservoir for plateau species. The exceptional ecological environment of the QTP has fostered diverse fish species. However, due to climate change and human activities, fish species in this area are facing serious threats, while large spatial scale

Uncovering scientific and multimodal literacy through audio description

The paper focuses on skills and competences applied in audio description (AD) of a Swedish multimodal popular scientific journal. The journal is made accessible for blind and visually impaired audiences by producing an audio version of its verbal and visual contents. The task of the sighted audio describer is to create a verbal description of the contents that activates internal images of the blin

Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs) : a multicentre, open-label, randomised, crossover trial

Background: Hypertension is the leading risk factor for cerebral small vessel disease. We aimed to determine whether antihypertensive drug classes differentially affect microvascular function in people with small vessel disease. Methods: We did a multicentre, open-label, randomised crossover trial with blinded endpoint assessment at five specialist centres in Europe. We included participants aged

AIRE is expressed in breast cancer TANs and TAMs to regulate the extrinsic apoptotic pathway and inflammation

Autoimmune regulator (AIRE) is a transcriptional regulator expressed in the thymus and necessary for maintaining immunological self-tolerance. Extra-thymic AIRE expression is rare and a role for AIRE in tumor-associated innate immune cells has not yet been established. In this study we show that AIRE is expressed in human pro-tumor neutrophils. In breast cancer, AIRE was primarily located to tumor

Anomalous binocular vision in African Harrier-Hawks

An animal's visual field is the three-dimensional space around its head from which it can extract visual information at any instant1. Bird visual fields vary markedly between species, and this variation is likely to be driven primarily by foraging ecology1,2,3. The binocular visual field is the region in which the visual fields of the two eyes overlap; thus, objects in the binocular field are imag

Superfluid-droplet crossover in a binary boson mixture on a ring : Exact diagonalization solutions for few-particle systems in one dimension

We investigate the formation of self-bound quantum droplets in a one-dimensional binary mixture of bosonic atoms, applying the method of numerical diagonalization of the full Hamiltonian. The excitation spectra and ground-state pair correlations signal the formation of a few-boson droplet when crossing the region of critical interspecies interactions. The self-binding affects the rotational excita

C-level managers and born-digitals' scaling : The case of Initial Coin Offerings (ICOs)

This research contributes to the Management of Technology (MOT) literature by scrutinizing the interrelation between education, experience, and the scaling aptitudes of high-tech companies. The study hinges on a comprehensive analysis of data collected from 1987 C-level executives and 3644 born-digital firms that pursued funding via blockchain-based Initial Coin Offerings (ICOs). Employing structu

Access Security Policy Generation for Containers as a Cloud Service

The rapid development of containerization technology comes with remarkable benefits for developers and operation teams. Container solutions allow building very flexible software infrastructures. Although lots of efforts have been devoted to enhancing containerization security, containerized environments still have a huge attack surface. Completely avoiding severe security issues have so far not be

Effekt av vägunderhålls- och reparationsarbeten på cyklister - Översikt av litteratur

En systematisk litteraturgenomgång gjordes avseende effekterna av vägunderhåll och reparationsarbeten på cyklister. Fynden visar att befintliga svenska riktlinjer är otydliga och inte tillräckligt tar hänsyn till cyklisters förutsättningar och behov. Det finns inte heller några tydliga exempel på hur cyklister ska hanteras i praktiken. Det finns ett tydligt behov av att utveckla tydliga standarder