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ESPRESSO mass determination of TOI-263b : An extreme inhabitant of the brown dwarf desert

The TESS mission has reported a wealth of new planetary systems around bright and nearby stars amenable for detailed characterizations of planet properties and atmospheres. However, not all interesting TESS planets orbit around bright host stars. TOI-263 b is a validated ultra-short-period substellar object in a 0.56-day orbit around a faint (V = 18.97) M 3.5 dwarf star. The substellar nature of T

Root influence on soil nitrogen availability and microbial community dynamics results in contrasting rhizosphere priming effects in pine and spruce soil

The rhizosphere priming effect (RPE) is increasingly considered an important regulator of below-ground C and N cycling, with implications for terrestrial ecosystem feedback to global change. Even so, there is a lack of knowledge about the mechanisms underlying RPEs. We used novel stable isotope probing methods to investigate RPEs in an experiment with Scots pine and Norway spruce seedlings, two of

Low MSP-1 haplotype diversity in the West Palearctic population of the avian malaria parasite Plasmodium relictum

Background: Although avian Plasmodium species are widespread and common across the globe, limited data exist on how genetically variable their populations are. Here, the hypothesis that the avian blood parasite Plasmodium relictum exhibits very low genetic diversity in its Western Palearctic transmission area (from Morocco to Sweden in the north and Transcaucasia in the east) was tested. Methods:

Dendritic spines are lost in clusters in Alzheimer’s disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a deterioration of neuronal connectivity. The pathological accumulation of tau in neurons is one of the hallmarks of AD and has been connected to the loss of dendritic spines of pyramidal cells, which are the major targets of cortical excitatory synapses and key elements in memory storage. However, the detailed m

Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens

Target protection proteins confer resistance to the host organism by directly binding to the antibiotic target. One class of such proteins are the antibiotic resistance (ARE) ATP-binding cassette (ABC) proteins of the F-subtype (ARE-ABCFs), which are widely distributed throughout Gram-positive bacteria and bind the ribosome to alleviate translational inhibition from antibiotics that target the lar

Family history of early onset acute lymphoblastic leukemia is suggesting genetic associations

Childhood acute lymphoblastic leukemia (ALL) has an origin in the fetal period which may distinguish it from ALL diagnosed later in life. We wanted to test whether familial risks differ in ALL diagnosed in the very early childhood from ALL diagnosed later. The Swedish nation-wide family-cancer data were used until year 2016 to calculate standardized incidence ratios (SIRs) for familial risks in AL

Recent molecular assessment of plasmodium vivax and plasmodium falciparum asymptomatic infections in botswana

In 2016, we reported the presence of Plasmodium vivax in Botswana through active case detection. A realtime PCR was used during a similar study in 10 districts to assess changes in the P. vivax prevalence. We assessed 1,614 children (2-13 years of age) for hemoglobin (Hb; g/dL) and Plasmodium parasites. The median age of all participants was 5.0 years (25th percentile, 3 years; 75th percentile, 8

A Janus-Faced Bacterium : Host-Beneficial and -Detrimental Roles of Cutibacterium acnes

The bacterial species Cutibacterium acnes (formerly known as Propionibacterium acnes) is tightly associated with humans. It is the dominant bacterium in sebaceous regions of the human skin, where it preferentially colonizes the pilosebaceous unit. Multiple strains of C. acnes that belong to phylogenetically distinct types can co-exist. In this review we summarize and discuss the current knowledge

The Calendars of Southeast Asia : 2: Burma, Thailand, Laos, and Cambodia

In this paper we investigate three Burmese calendars: the Arakanese, Makaranta and Thandeikta calendars. It is shown that the lunar calendar of the two first ones imply a tropical solar year, something that puts the lunar calendar out of phase with the sidereal solar calendar used and possibly indicates a Hellenistic origin. We then examine the calendars of Thailand, Laos and Cambodia, which super

The Calendars of Southeast Asia : 4: Malaysia and Indonesia

The archipelago region of Southeast Asia is characterised by a great number of calendars of which we treat only a few. The early calendars were essentially original Indian calendars although with modified intercalation schemes. From the fifteenth century in the Christian era the region was increasingly dominated by Islamic influences and successively adopted Muslim calendars although with some mod

The Calendars of Southeast Asia : 5: Eclipse Calculations, and the Longitudes of the Sun, Moon and Planets in Burmese and Thai Astronomy

Many of the calendrical records in Southeast Asia contain information on the longitudes of the Sun, the Moon and the planets—something that is valuable for the dating of these records. Both the Burmese and the Thai use calculation schemes for the longitudes of the Sun, the Moon, and the planets that are almost identical to the original Sūryasiddhānta schemes. After the change to the Thandeikta cal

The Calendars of Southeast Asia : 6: Calendrical Records

Calendrical inscriptions and chronicles are an important source of information on the history and civilisation of Southeast Asia. Most of the records are horoscopes but there are also inscriptions commemorating the foundation of temples and other important buildings, and on Buddha images. Stone inscriptions are necessarily commemorative and the event celebrated is frequently of considerable social

Medieval astronomical clocks in the Baltic region and the mysterious golden numbers in Gdansk

Large medieval clocks were built in a number of Hanseatic towns in the Baltic region from the end of the fourteenth century to the middle of the fifteenth century. Several factors contributed to their building: there was a need for public display of time in the rapidly growing medieval towns, the technique of constructing mechanical clocks became available with the invention of the verge escapemen

An analysis of the golden numbers on the calendar disk of the astronomical clock in Lund

We investigate the golden numbers on the calendar disk of the astronomical clock in Lund, Sweden. Using methods of internal consistency we find printing errors and locate several golden numbers misplaced by one day. However, from the available data it is not possible to determine the principles that were used for calculation of the location of these golden numbers when the calendar disk was restor

Father Antoine Thomas and the Birth of ‘Modern Astronomy’ in Thailand

‘Modern astronomy’ was introduced to Siam (present-day Thailand) when the Belgian Jesuit missionary-astronomer Father Antoine Thomas carried out astronomical observations in 1681 and 1682 in order to determine the latitude and longitude of Ayutthaya. Three years later a contingent of French Jesuit missionary astronomers observed a total lunar eclipse from Lop Buri, which marked the start of an int

Model optimization for autotuners in industrial control systems

Automatic tuning of PID controllers using relay feedback experiments has received attention on and off since it was first proposed and industrially implemented in a control system in the 1980s. While optimal experiment design and modern system identification easily outperform the original automatic tuner, they rely on computational resources that are not always available in industrial control syst

Tabletop divergent-light halos

We study artificial halos generated by microscopic crystals suspended in an aqueous solution which is illuminated by a divergent light source. By measuring the diameters of the halos we can deduct the refracting angles of the crystals and compare them with known values.

Showcasing Seventeenth-Century Jesuit Astronomy In Asia : The Lead Up To The First Scientific Observations Of A Solar Eclipse Made In Siam

The first great ruler to encourage the adoption of Western culture and technology throughout Siam was King Narai, who also had a passion for astronomy. He showed this by encouraging French and other Jesuit missionaries, some with astronomical interests and training, to settle in Siam from the early 1660s. One of these was Father Antoine Thomas, and he was the first European known to have carried o