In order to advance the understanding of which types of regional innovation system represent effective innovation support for what kinds of industry in different regions analyses must be contextualised by reference to the actual knowledge base of various industries as well as to the regional and national institutional framework, which strongly shape the innovation processes of firms. Of special im

Tobacco use is one of the major risk factors of cardiovascular disease. The underlying molecular mechanisms that link cigarette smoke to cardiovascular disease remain unclear. The present study was designed to examine the effects of dimethyl sulfoxide (DMSO)-soluble smoke particles (DSPs) on human aortic smooth muscle cell (HASMC) cultures, and to explore the mitogen-activated protein kinase (MAPK

Mucosal surfaces of the reproductive tract as well as their secretions have important roles in preventing sexual transmission of HIV-1. In the current study, the majority of the intrinsic anti-HIV-1 activity of human seminal plasma (SP) was determined to reside in the cationic polypeptide fraction. Antiviral assays utilizing luciferase reporter cells and lymphocytic cells revealed the ability of w

The aim of the article is to discuss the interpretation of the Romanesque round church towers in Scandinavia. The article focuses on the 15-19 churches with round towers in medieval Denmark, Sweden and Norway, with the main part in Southern Schleswig and Scania; none are known from Finland. The chronology and social context, function and meaning of the church towers are discussed. Finally a list o

We present a computational tool to develop an exhaust gas recirculation (EGR) - air-fuel ratio (AFR) operating range for homogeneous charge compression ignition (HCCI) engines. A single- cylinder Ricardo E-6 engine running in HCCI mode, with external EGR is simulated using an improved probability density function (PDF)-based engine cycle model. For a base case, the in-cylinder temperature and unbu

What exactly are opinions? What does it mean to express an attitude? Given the ubiquitous use of surveys, polls and rating scales, it seems we ought to have firm answers to these fundamental questions, but we do not. Here we present a novel approach to investigate the nature of attitudes. We created a self-transforming paper survey of moral opinions, covering both foundational principles, and curr

We have addressed the importance of B cell tolerance to collagen type II, a matrix protein, which is a target in rheumatoid arthritis (RA) and its mouse models. We generated a germline-encoded anti-collagen type II (CII) IgH replacement anti-C1 B cell mouse strain (ACB) to investigate how B cell tolerance to CII, a matrix protein, is subverted and to further understand pathogenesis of RA. Phenotyp

Abstract not available.

There are two interpretations of rhetoric that are backed by a long tradition: as the theory of argumentation and persuasion, which is how it was born in Antiquity, and as the taxonomy of rhetorical figures, which is the form in which it reigned supreme from the 16th century onwards. In both of these senses, advertising discourse today is the favoured, and in fact almost exclusive, domain of rheto

This dissertation uses longitudinal micro-data from Stockholm between 1878 and 1926 to study the causes and consequences of the fertility transition and to examine the development of living standards inequality during industrialization. Although both processes have received much interest from researchers, we know relatively little of how either one played out among individuals in urban areas, whic

En diskussion om historieskrivning i amerikansk film med utgångspunkt i Mats Jönssons doktorsavhandling i filmvetenskap, Film och historia. Historisk Hollywoodfilm 1960-2000.

AZD0837 is an investigational oral anticoagulant which is converted to the active form, ARH067637, a selective direct thrombin inhibitor. The present study, a multicentre, randomised, parallel-group, dose-guiding study, assessed the safety and tolerability of an immediate-release formulation of AZD0837 compared with dose-adjusted warfarin in the prevention of stroke and systemic embolic events in

Desmoplastic fibroblastoma (DF) is a benign fibroblastic/myofibroblastic tumor. Cytogenetic analyses have revealed consistent rearrangement of chromosome band 11q12, strongly suggesting that this region harbors a gene of pathogenetic importance. To identify the target gene of the 11q12 rearrangements, we analyzed six cases diagnosed as DF using chromosome banding, fluorescence in situ hybridizatio

AIMS/HYPOTHESIS: The enzyme hormone-sensitive lipase (HSL) is produced and is active in pancreatic beta cells. Because lipids are known to play a crucial role in normal control of insulin release and in the deterioration of beta cell function, as observed in type 2 diabetes, actions of HSL in beta cells may be critical. This notion has been addressed in different lines of HSL knockout mice with co

The biochemical mechanisms underlying glucose-stimulated insulin secretion from pancreatic beta-cells are not completely understood. To identify metabolic disturbances in beta-cells that impair glucose-stimulated insulin secretion, we compared two INS-1-derived clonal beta-cell lines, which are glucose-responsive (832/13) or glucose-unresponsive (832/2). We found that despite a marked impairment o

Cancer patients diagnosed with type 2 diabetes mellitus (T2DM) are at an increased risk of death due to cancer. However, whether T2DM comorbidity increases other causes of death in cancer patients is the novel theme of this study. Patients with T2DM were identified from the nationwide Swedish Hospital Discharge Register and linked with patients with cancer recorded from the Swedish Cancer Registry