BACKGROUND: Factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are associated with risk of arterial and venous thrombosis and with hemorrhagic disorders. We aimed to identify and functionally test novel genetic associations regulating plasma FVIII and VWF. METHODS: We meta-analyzed genome-wide association results from 46 354 individuals of European, African, East Asian, and Hi

OBJECTIVE: Exposure to hyperoxemia and hypoxemia is common in out-of-hospital cardiac arrest (OHCA) patients following return of spontaneous circulation (ROSC), but its effects on neurological outcome are uncertain, and study results are inconsistent. METHODS: Exploratory post hoc substudy of the Target Temperature Management (TTM) trial, including 939 patients after OHCA with return of spontaneou

“Fram” i kapitlets titel, “att skriva fram den andra”, är valt med omsikt. Det syftar till att lyfta fram textens förmåga att skapa det den beskriver. Texter som beskriver “kvinnor”, “homosexuella”, “arbetarklassen” eller “invandrare” skapar först kvinnor, homosexuella, arbetarklassen eller invandrare som befintliga grupper värda att skildra. Därefter skriver man om dessa grupper som om de r

A drilling task requires a mechanism with five degrees of freedom, in order to achieve the correct position and orientation of the drilling tool. When performed with a standard 6-axes industrial robot, this task leaves an extra degree of freedom that can be exploited in order to achieve any additional criterion. Unfortunately, typical industrial robotic control architectures do not allow the user

Modern industrial robots are fast and have very good repetitional accuracy, which have made them indispensable in many manufacturing applications. However, they are usually programmed to follow desired trajectories and only get feedback from position sensors. This works fine as long as the environment is very well structured, but does not give good robustness to objects not being positioned or gri

Potatoes served in large-scale food service systems are often of poor quality. The current recommendation is to cook the potatoes until the core has reached a temperature of 96°C, but this recommendation is questionable. In this study, three potato varieties have been cooked by using conventional boiling (CB) to temperatures of 94°C and 96°C and steam cooking (SC) to temperatures of 92°C, 94°C and

We present the extension of ptychography for three-dimensional object reconstruction in a tomography setting. We describe the alternating direction method of multipliers (ADMM) as a generic reconstruction framework to efficiently solve the nonlinear optimization problem. In this framework, the ADMM breaks the joint reconstruction problem into two well-defined subproblems: ptychographic phase retri

In social science discourse, the dichotomy between agency and structure tends to dominate debates pertaining to identity construction. When complex social facts are viewed through a simplistic prism of either individual activities or dominant structural impacts is likely to lead to a conclusion, - particularly when the subjects of research are members of communities at risk of vulnerability- which

Deuterated biomolecules - where hydrogen atoms (H) are exchanged to its isotope deuterium (D) - are essential for biological experiments in neutron scattering, but they are not readily available. In neutron scattering, D has a strong positive coherent scattering length (6.67 fm) in comparison with the negative scattering length of H (-3.74 fm). These different characteristics of neutrons to D and Deuterated biomolecules - where hydrogen atoms (H) are exchanged to its isotope deuterium (D) - are essential for biological experiments in neutron scattering, but they are not readily available. In neutron scattering, D has a strong positive coherent scattering length (6.67 fm) in comparison with the negative scattering length of H (-3.74 fm). These different characteristics of neutrons to D and

Control of robotic systems subject to friction phenomena is an important issue since growing demands on accuracy require elimination of friction disturbances. If several modelse.g., friction model, rigid-body dynamicsare required to describe the behavior with high precision, each model requires the knowledge of numerous parameters (perhaps time-varying) as well as an increased number of signals an

We study the extension of the class of linear time-invariant open-loop systems that may be transformed into SPR systems introducing a reduced-order observer. It is shown that for open-loop stable systems a cascaded observer achieves the result. For open-loop unstable systems observer-based feedback is required to succeed. In general, any stabilizable and observable system may be transformed into a

The paper suggests conditions for presence of quadratic Lyapunov functions for nonlinear observer based feedback systems with an 'input nonlinearity' in the feedback path. Provided that the system using state feedback satisfies the Circle Criterion (i.e., when all states can be measured), we show that the extended system with only output feedback control from a (full state) Luenberger-type observe

This paper presents a new control strategy for an underactuated two-link robot, called the Pendubot. The goal is to create stable oscillations of the outer link of the pendubot, which is not directly actuated. We exploit a recently proposed feedback control design strategy, based on motion planning via virtual holonomic constraints. This strategy is shown to be useful for design of regulators for

A passive approximation problem is formulated where the target function is an arbitrary complex-valued continuous function defined on an approximation domain consisting of a finite union of closed and bounded intervals on the real axis. The norm used is a weighted L p -norm where 1 ≤ p ≤ ∞. The approximating functions are Herglotz functions generated by a measure with Holder continuous density i