Interactome Mapping of Plasminogen-interactive Proteins from Group A Streptococcus by Integrated Mass Spectrometry-based Proteomics
Streptococcus pyogenes is a host-adapted human pathogen responsible for causing various infectious diseases, including rheumatic heart disease and acute rheumatic fever, some of which can be fatal to humans. The bacteria contain different pathogenic proteins situated on the cell surface or secreted extracellularly. Many of these proteins have the ability to bind to and activate human plasminogen.
