The proper alignment of requirements engineering and testing (RET) can be key to software's success. Three practices can provide effective RET alignment: using test cases as requirements, harvesting trace links, and reducing distances between requirements engineers and testers. The Web extra https://youtu.be/M65ZKxfxqME is an audio podcast of author Elizabeth Bjarnason reading the the Requirements

Gene transfer is a promising drug delivery method of advanced therapeutic entities for Parkinson's disease. One advantage over conventional therapies, such as peripheral delivery of the dopamine pre-cursor L-DOPA, is site-specific expression of proteins with regenerative, disease-modifying and potentially neuroprotective capacity. Several clinical trials have been performed to test the capacity of

This study deals with the diffusion of a new medical technology — vaccination against smallpox — in nineteenth-century Scania in Sweden. Using an aggregated sample of parishes as well as a micro-level dataset for four parishes, we investigate the socioeconomic as well as the geographical patterns of diffusion of vaccination in the province. We also relate the adoption of vaccination across geograp

Obesity and its associated comorbidities (for example, diabetes mellitus and hepatic steatosis) contribute to approximately 2.5 million deaths annually and are among the most prevalent and challenging conditions confronting the medical profession. Neurotensin (NT; also known as NTS), a 13-amino-acid peptide predominantly localized in specialized enteroendocrine cells of the small intestine and rel

Identifying the molecular basis of environmentally induced phenotypic variation presents exciting opportunities for furthering our understanding of how ecological processes and the environment can shape the phenotype. Urban and rural environments present free-living organisms with different challenges and opportunities, which have marked consequences for the phenotype, yet little is known about re

Parkinson's disease (PD) patients experience loss of normal motor function (hypokinesia), but can develop uncontrollable movements known as dyskinesia upon treatment with L-DOPA. Poverty or excess of movement in PD has been attributed to overactivity of striatal projection neurons forming either the indirect (iSPNs) or the direct (dSPNs) pathway, respectively. Here, we investigated the two pathway

Sverige har sedan december 2008 liberalare regler för arbetskraftsinvandring från ”tredje land” (länder utanför EU/EES) än kanske något annat land. De nya reglerna gäller alla yrken oberoende av kvalifikationsgrad eller om det är fråga om ett bristyrke eller inte. Artikeln handlar om de cirka 500 arbetskraftsmigranter från tredje land som 2012 beviljades arbetstillstånd i restaurang- och städbrans

Water loss is a crucial factor for vegetation in the semi-arid Sahel region of Africa. Global satellite-driven estimates of plant CO2 uptake (gross primary productivity, GPP) have been found to not accurately account for Sahelian conditions, particularly the impact of canopy water stress. Here, we identify the main biophysical limitations that induce canopy water stress in Sahelian vegetation and

Background. Exposure to allergens plays a role in the development of atopic sensitization and influences allergic phenotype. House dust mites (HDM) are a common source of aeroallergens in many parts of the world. The relationship between indoor environment factors such as temperature, moisture/humidity, and ventilation and HDM allergen load is complex. Methods. Part of a larger study into the heal

We build a 3d face shape model, including inter- and intra-shape variations, derive the analytical jacobian of its resulting 2d rendered image, and show example of its fitting performance with light, pose, id, expression and texture variations.

BACKGROUND: Rice husks (RH) are agricultural residues with abundant storage of cellulose and hemicellulose, making them a potential feedstock for polyhydroxyalkanoate (PHA) production. In this study, optimization of pretreatment with alkali under various conditions was performed before enzymatic hydrolysis using Celluclast 1.5 L (EC 3.2.1.4) and Novozyme 188 (EC 3.2.1.21). The hydrolysate was fed