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Identification of New CTX Analogues in Fish from the Madeira and Selvagens Archipelagos by Neuro‐2a CBA and LC‐HRMS

Ciguatera Poisoning (CP) is caused by consumption of fish or invertebrates contaminated with ciguatoxins (CTXs). Presently CP is a public concern in some temperate regions, such as Macaronesia (North‐Eastern Atlantic Ocean). Toxicity analysis was performed to characterize the fish species that can accumulate CTXs and improve understanding of the ciguatera risk in this area. For that, seventeen fis

Use of mass spectrometry to determine the diversity of toxins produced by gambierdiscus and fukuyoa species from Balearic Islands and Crete (Mediterranean Sea) and the Canary Islands (Northeast Atlantic)

Over the last decade, knowledge has significantly increased on the taxonomic identity and distribution of dinoflagellates of the genera Gambierdiscus and Fukuyoa. Additionally, a number of hitherto unknown bioactive metabolites have been described, while the role of these compounds in ciguatera poisoning (CP) remains to be clarified. Ciguatoxins and maitotoxins are very toxic compounds produced by

Toxicity characterisation of Gambierdiscus species from the Canary Islands

In the last decade, several outbreaks of ciguatera fish poisoning (CFP) have been reported in the Canary Islands (central northeast Atlantic Ocean), confirming ciguatera as an emerging alimentary risk in this region. Five Gambierdiscus species, G. australes, G. excentricus, G. silvae, G. carolinianus and G. caribaeus, have been detected in macrophytes from this area and are known to produce the ci

Toxicity screening of a gambierdiscus australes strain from the western mediterranean sea and identification of a novel maitotoxin analogue

Dinoflagellate species of the genera Gambierdiscus and Fukuyoa are known to produce ciguatera poisoning-associated toxic compounds, such as ciguatoxins, or other toxins, such as maitotoxins. However, many species and strains remain poorly characterized in areas where they were recently identified, such as the western Mediterranean Sea. In previous studies carried out by our research group, a G. au

Gambierdiscus and Fukuyoa as potential indicators of ciguatera Risk in the Balearic Islands

Gambierdiscus and Fukuyoa are genera of toxic dinoflagellates which were mainly considered as endemic to marine intertropical areas, and that are well known as producers of ciguatoxins (CTXs) and maitotoxins (MTXs). Ciguatera poisoning (CP) is a human poisoning occurring after the consumption of fish or more rarely, shellfish containing CTXs. The presence of these microalgae in a coastal area is a

Further advance of Gambierdiscus Species in the Canary Islands, with the First Report of Gambierdiscus belizeanus

Ciguatera Poisoning (CP) is a human food-borne poisoning that has been known since ancient times to be found mainly in tropical and subtropical areas, which occurs when fish or very rarely invertebrates contaminated with ciguatoxins (CTXs) are consumed. The genus of marine benthic dinoflagellates Gambierdiscus produces CTX precursors. The presence of Gambierdiscus species in a region is one indica

Religious Extremism

This chapter analyses the use of violence in the name of religion. Religious extremism is an ideology of certain movements, groups, individuals in denominations and religious organizations, characterised by adherence to extreme interpretations of dogma. It also involves methods of action by these parties to achieve their goals and spread their views and influence. The purpose of religious extremis

Inferior fixation with a new pin design for external fixation: A randomized study in 50 patients operated on by the hemicallotasis technique.

Background and purpose Tibial osteotomy by the hemicallotasis technique (HCO) requires strong pin fixation. We compared pin fixation in HCO using a new self-drilling XCaliber pin (Orthofix) with optimized thread and tip design, with the commonly used standard pin (Orthofix). Patients and methods 50 patients, mean age 51 (35-66) years, to be treated by HCO were randomized to standard pins or XCalib

Ticagrelor induces adenosine triphosphate release from human red blood cells.

RATIONALE: The novel P2Y(12) antagonist ticagrelor inhibits ADP-induced platelet aggregation more rapidly and more potently than clopidogrel. Clinical trials have revealed dyspnea and asymptomatic ventricular pauses as side effects of ticagrelor. The mechanism behind these side effects is not known, but it is plausible that they are mediated by adenosine. OBJECTIVE: Ticagrelor is known to increas

Coronary artery stenosis in asymptomatic child after arterial switch operation: detection by transthoracic colour-flow doppler echocardiography.

Arterial switch operation (ASO) has become the definitive anatomical correction for transposition of great arteries (TGA). Left coronary artery (LCA) ostial stenosis was detected by transthoracic Doppler echocardiography (TTDE) as a flame like colour flow diastolic signal and coronary flow reserve (CFR) was low, 1.3. It was treated successfully by a drug-eluted stent. These findings could be diagn

Alexithymia in anorexia nervosa: a controlled study using the 20-item Toronto Alexithymia Scale

The 20-item Toronto Alexithymia Scale (TAS) was completed at the age of 22 years by individuals who had previously suffered from anorexia nervosa (AN), and also by members of a comparison group. The AN and comparison groups had been recruited from community samples. Overall, the TAS scores did not clearly discriminate between the two groups. However, the AN group was significantly more often repre