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https://www.virus-biophysics.lu.se/teaching - 2025-12-31

January 9, 2024 , Physics World "Viruses change structure at the temperature of the human body to better infect us". https://physicsworld.com/a/viruses-change-structure-at-the-temperature-of-the-human-body-to-better-infect-us/  November 8, 2023,  Lund University press release on our pioneering study published in PNAS showing how temperature triggers release of viral genome by changing the form and

https://www.virus-biophysics.lu.se/news-0 - 2025-12-31

To see Prof. Alex Evilevitch Open Researcher and Contributor ID (ORCID), click the link below (it opens another website):https://orcid.org/0000-0002-0245-9574   Below, there is the full list of publication of Prof. Alex Evilevitch. It links to another webpage related to the publisher.Villanueva Valencia J. R.,  Li D.,  Casjens S. R.,  Evilevitch A., "‘SAXS-osmometer’ method provides measurement of

https://www.virus-biophysics.lu.se/publications - 2025-12-31

We use atomic force microscopy (AFM) nano-indentation method to measure DNA mobility in the capsid. The mobility of DNA packaged inside the HSV-1 capsid is measured by recording the force resisting the capsid indentation when the AFM tip is brought into contact with the DNA-filled capsid in solution. Force resisting the AFM tip indentation of the capsid is recorded as the force-distance curve. Cap

https://www.virus-biophysics.lu.se/methods-and-techniques/atomic-force-microscopy - 2025-12-31

We use cryo electron microscopy (cryo-EM) and image reconstruction to examine the virion structure at subnanometer resolution. We also analyze structure and density of viral DNA packaged in a capsid.  Figure: Cutaway views from cryo-EM reconstructions of (A) HSV-1 C-capsid and (B) phage lambda procapsid and mature DNA-filled lambda capsid. HSV-1 and lambda phage capsids are shown to scale. Owing t

https://www.virus-biophysics.lu.se/methods-and-techniques/cryo-electron-microscopy - 2025-12-31

The isothermal titration calorimetry (ITC) provides the most direct method to measure the internal energy of the confined viral genome. In order to experimentally dissect the thermodynamic determinants of viral DNA packaging and ejection energetics, we were first to use ITC to directly measure the heat released by DNA ejection from a virus capsid. This approach allows one to address experimentally

https://www.virus-biophysics.lu.se/methods-and-techniques/microcalorimetry - 2025-12-31

Super-Resolution Structured Illumination Microscopy (SR-SIM) provides resolutions down to 120 nm, allowing visualization of individual herpesvirus capsids (HSV-1) attached to the nucleus (HSV-1 C-capsid diameter is 125 nm).  Figure: Imaging of reconstituted capsid-nuclei system confirms specific capsid binding to the NPCs at the nuclear membrane. Representative super-resolution SIM image showing G

https://www.virus-biophysics.lu.se/methods-and-techniques/super-resolution-and-single-particle-fluorescence-microscopy - 2025-12-31

Despite the structure of packaged viral DNA being central for ejection and consequentially infectivity of the virus, the detailed understanding of the packing structure of DNA inside the viral capsid. SAXS and SANS allow investigation of the structure of DNA filled capsids in solution in a wide range of environmental conditions. SAXS and SANS are powerful techniques that provides detailed structur

https://www.virus-biophysics.lu.se/methods-and-techniques/small-angle-x-ray-scattering-saxs-and-small-angle-neutron-scattering-sans-viral-genomes - 2025-12-31

For many double stranded (ds) DNA viruses the viral genome is actively packaged into the virus capsid by a powerful molecular motor. This results in an energetically unfavorable state of the packaged genome, creating tens of atmospheres internal pressure inside the virion. Using a new calorimetric assay to determine the activation energy barriers associated with genome loss in response to elevated

https://www.virus-biophysics.lu.se/covers-highlights - 2025-12-31

Leading research in psychological defence About the institute... The Lund University Psychological Defence Research Institute (Forskningsinstitutet för psykologiskt försvar) is a multidisciplinary research unit within the Department of Communication. Our work focuses on the theory and practice of psychological defence, with a focus on research into analyzing and countering hostile information infl

https://www.psychologicaldefence.lu.se/start - 2025-12-31

The Lund University Psychological Defence Research Institute (Forskningsinstitutet för psykologiskt försvar) is a multidisciplinary research unit within the Department of Communication. Our work focuses on the theory and practice of psychological defence and research into analyzing and countering hostile information influence operations and hybrid threats. The purpose of psychological defence is t

https://www.psychologicaldefence.lu.se/about-institute - 2025-12-31

Attribution – Data – Analysis – Countermeasures. InterOperability ADAC.io is a Horizon project coordinated by the Psychological Defence Research Institute As of 1 February 2024, the Psychological Defence Research Institute coordinates the Horizon project ADAC.io, engaging seven partners in a three-year-long project. Based on the concept of Foreign Information Manipulation & Interference (FIMI) as

https://www.psychologicaldefence.lu.se/adacio - 2025-12-31

Below are some of the main publications by the Psychological Defence Research Institute and our affiliates. 2025Fredheim, R., Isaksson, E., & Pamment, J. (2025). AI-Assisted Analysis of War-Related Content on Grey Zone Domains. Lund University, Psychological Defence Research Institute, Working paper 2025:1Falkheimer, J. & Pamment, J. (2025). The dark and unexplored side of strategic communication

https://www.psychologicaldefence.lu.se/research - 2025-12-31

Researcher profiles feature researchers connected to the Psychological Defense Research Institute as affiliates, visiting researchers, or employees. Hilkka Grahn Rolf Fredheim Elsa Hedling Jana Wrange

https://www.psychologicaldefence.lu.se/researcher-profiles - 2025-12-31

https://www.protein-chemistry.lu.se/protein-chemistry-group - 2025-12-31

The Medical Protein Chemistry research group headed by prof. Anna Blom is located at the Wallenberg Laboratory within Skåne University Hospital in Malmö. The group is focused on the complement system in health and disease. Our ambition is to make high quality basic science based on clinically relevant questions and yielding novel diagnostic approaches and clinical interventions. Our research is su

https://www.protein-chemistry.lu.se/anna-blom-research-group-0 - 2025-12-31

The Medical Protein Chemistry research group headed by prof. Anna Blom is located at the Wallenberg Laboratory within Skåne University Hospital in Malmö.  The group is focused on the complement system in health and disease. The complement, crucial part of innate immune system is involved in many basic biological processes such as defence against infections but when activated in a wrong place or no

https://www.protein-chemistry.lu.se/protein-chemistry-research-group - 2025-12-31

Best publications from our group over past years. King B.C., Kulak K, Krus U., Rosberg R., Golec E., Wozniak K., Gomez M.F., Zhange E., O'Connell D., Renström E. and Blom A.M. (2019) Complement C3 proteinst against autophagy related beta-cell detah via ATG16L1 interaction and regulation of autophagy., Cell Metabolism, 29, 202-210.Kulak K., Kuska K., Colineau L., Mckay M., Maziarz K., Slaby J., Blo

https://www.protein-chemistry.lu.se/top-publications - 2025-12-31

List of selected publications from our research group exemplifying the projects we are conducting. Blom. A. M., Pertoft H. and Fries E. (1995) Inter-a-inhibitor is required for the formation of the hyaluronan-containing coat on fibroblasts and mesothelial cells. J. Biol. Chem., 270, 9698-9701. Blom A. M., Mörgelin M., Öyen M., Jarvet J. and Fries E. (1999) Structural characterization of inter-a-in

https://www.protein-chemistry.lu.se/top-publications/selected-publications-group - 2025-12-31

In blood, complement proteins are a major component and perhaps therefore most of these were identified already decades ago. However, only in recent years it has become apparent that complement not only plays a major role in innate defense against pathogens but also identifies foreign materials and removes waste (immune complexes and dying cells). The physiological relevance of complement is demon

https://www.protein-chemistry.lu.se/projects - 2025-12-31