Published 25 October 2019 It has been argued that survival bias may distort results in Mendelian randomization studies in older populations. Through simulations of a simple causal structure we investigate the degree to which instrumental variable (IV)-estimators may become biased in the context of exposures that affect survival. We observed that selecting on survival decreased instrument strength

https://www.lupop.lu.se/article/survival-bias-mendelian-randomization-studies-threat-causal-inference - 2024-12-26

Published 28 October 2019 At present, we know relatively little about priorities and problems with topics that older adults experience when completing different examinations in longitudinal population-based studies. To examine these topics, research must be adapted to investigate the meanings, motivations, and interpretations of the individual participants themselves. New publication in BMC Geriat

https://www.lupop.lu.se/article/was-it-worth-it-older-adults-experiences-participating-population-based-cohort-study-focus-group - 2024-12-26

Published 29 October 2019 To compare the risk and severity of prostate cancer between men achieving fatherhood by assisted reproduction and men conceiving naturally. New publication in thebmj.Read more here.

https://www.lupop.lu.se/article/risk-prostate-cancer-men-fathering-through-assisted-reproduction-nationwide-population-based - 2024-12-26

Published 30 October 2019 Breast cancer is the most common cancer and the leading cause of cancer-related death in females, with a large societal and economic impact. Decisions regarding its treatment are largely affected by the categorization into different subtypes with hormone receptor status and HER2 status being the most important predictive factors. New publication in SAGE Journals.Read more

https://www.lupop.lu.se/article/cancer-registries-guardians-breast-cancer-biomarker-information-systematic-review - 2024-12-26

Published 31 October 2019 The FMA is a validated 10-item patient-centered outcome measure that investigates satisfaction in performing common mobility-related activities of daily living. The UDS includes variables related to age, diagnosis, and type of device used, as well as health, participation, and environmental factors. New publication in Archives of Physical Medicine and Rehabilitation.Read

https://www.lupop.lu.se/article/development-and-implementation-wheelchair-outcomes-registry - 2024-12-26

Published 1 November 2019 In married individuals, resident children are associated with a reduction in basal risk for AUD which is stronger in mothers than fathers and with younger v. older children. This effect is also evident during high-risk periods. In mothers, our results are consistent with a largely causal effect. New publication in Psychological Medicine.Read more here.

https://www.lupop.lu.se/article/impact-parenthood-risk-registration-alcohol-use-disorder-married-individuals-swedish-population - 2024-12-26

Published 4 November 2019 Both clinical trials and registries are essential and complementary research methods and the strengths and weaknesses of each need to be recognized. The specific characteristics of registry research deserve to be acknowledged and safeguarded in the regulations governing clinical investigations with medical devices. New publication in SAGE Journals.Read more here

https://www.lupop.lu.se/article/research-methodology-and-practical-issues-relating-conduct-medical-device-registry - 2024-12-26

Published 5 November 2019 Employing Norwegian register data in a between-group comparison illustrates that register data would be particularly useful for several key areas of an RCT, including as a source of pilot data, to expand the range of variables on which between-group equivalence can be demonstrated, to increase the length of the observation period, to expand the number and type of individu

https://www.lupop.lu.se/article/potential-incorporating-administrative-register-data-randomized-experiments - 2024-12-26

Published 6 November 2019 New publication in Web of Science.Read more here.

https://www.lupop.lu.se/article/gdpr-and-research-exemption-considerations-necessary-safeguards-research-biobanks-0 - 2024-12-26

Published 7 November 2019 The National Cancer Database (NCDB) continues to evolve to improve the care of the cancer patient. Over the last 30 years, the NCDB has compiled nearly 40 million patient records submitted by over 1500 hospitals across the country. Addressing new challenges, the NCDB is transitioning to ensure data flow is more timely and data collection more efficient. New publication in

https://www.lupop.lu.se/article/national-cancer-database-past-present-and-future-cancer-registry-and-its-efforts-improve-quality - 2024-12-26

Published 8 November 2019 Social position is known to play a role in the quality of ageing, notably through the stimulation/dysregulation of key physiological systems in response to external stresses. Using data from one wave of Understanding Society including 9088 participants, we defined, as an extension of the allostatic load, a synthetic Biological Health Score (BHS) capturing the wear-and-tea

https://www.lupop.lu.se/article/early-life-inequalities-and-biological-ageing-multisystem-biological-health-score-approach - 2024-12-26

Published 4 November 2019 FFG-Academy Webinar on how to identify ethical issues at the proposal phase and how to address them properly in the project implementation phase Read more here.

https://www.lupop.lu.se/article/getting-ready-research-ethics-and-research-integrity-horizon-2020 - 2024-12-26

Published 11 November 2019 There are no currently agreed upon international standards for reporting of pediatric deceased organ donation activity. This leads to difficulty in comparisons between jurisdictions for both researchers and policy stakeholders. The goal of this project was to develop and test a standardized registry for pediatric deceased donation activity. New publication in Pediatric T

https://www.lupop.lu.se/article/development-multinational-registry-pediatric-deceased-organ-donation-activity - 2024-12-26

Published 6 November 2019 Statistik missbrukas i syfte att driva opinion mot klimatmarscherna, skriver en rad svenska forskare i en replik till Bjart Holtsmark från Norges statistiska centralbyrå. Hela artikeln

https://www.lupop.lu.se/article/klimatkrisens-effekter-ar-fakta-inte-asikter - 2024-12-26

Published 12 November 2019 The scientific debate following the initial formulation of the “bad luck” hypothesis in cancer development highlighted how measures based on analysis of variance are inappropriately used for risk communication. The notion of “explained” variance is not only used to quantify randomness, but also to quantify genetic and environmental contribution to disease in heritability

https://www.lupop.lu.se/article/commonly-used-estimates-genetic-contribution-disease-are-subject-same-fallacies-bad-luck-estimates - 2024-12-26

Published 13 November 2019 Whole-genome sequencing (WGS) brings comprehensive insights to cancer genome interpretation. To explore the clinical value of WGS, we sequenced 254 triple-negative breast cancers (TNBCs) for which associated treatment and outcome data were collected between 2010 and 2015 via the population-based Sweden Cancerome Analysis Network–Breast (SCAN-B) project (ClinicalTrials.go

https://www.lupop.lu.se/article/whole-genome-sequencing-triple-negative-breast-cancers-population-based-clinical-study - 2024-12-26

Av press [at] med [dot] lu [dot] se (Sara Liedholm) - publicerad 21 december 2022 Bild: iStock/lyosha_nazarenko. Doktoranden Karl Teurneau-Hermansson, ST-läkare i thoraxkirurgi och sedan tidigare specialist i allmänkirurgi är en av årets Teggerstipendiater. Hans forskning syftar till att förhindra neurologiska skador hos patienter som opereras för akut typ A aortadissektion. Aortadissektion är en

https://www.medicin.lu.se/artikel/mer-tid-till-forskning-tack-vare-teggerstiftelsen - 2024-12-26

Av asa [dot] hansdotter [at] med [dot] lu [dot] se (Åsa Hansdotter) - publicerad 29 december 2022 Bild: iStock/Vladimir Sukachev Jul och nyår är familjens högtider med glädje, fest, omtanke och gemenskap. Men för många kan det istället innebära en tid av ensamhet, ekonomisk utsatthet och ökad risk för alkohol- och spelberoende. Men det finns hjälp att få mot beroendesjukdomar. Det visar inte minst

https://www.medicin.lu.se/artikel/personer-med-beroende-extra-utsatta-under-jul-och-nyarshelgerna - 2024-12-26

Av sara [dot] liedholm [at] med [dot] lu [dot] se (Sara Liedholm) - publicerad 5 januari 2023 Foto: iStock Denis Zbukarev För några år sedan fick Johannes Ehinger en halv miljon kronor, det största anslag som Hörselforskningsfonden någonsin delat ut. I år får han ytterligare 290 000 kronor. Johanna Elander har beviljats 300 000 kronor. Genetiska orsaker till hörselnedsättning undersöks ofta hos ny

https://www.medicin.lu.se/artikel/anslag-till-horselforskning - 2024-12-26

Av asa [dot] hansdotter [at] med [dot] lu [dot] se (Åsa Hansdotter) - publicerad 9 januari 2023 Melanomforskaren Göran Jönsson vid Lunds universitet är Årets cancerforskare. Foto: André de Loisted Professor Göran Jönsson tilldelas Cancerfondens utmärkelse ”Årets cancerforskare 2023”. För sitt framgångsrika forskningsarbete inom immunterapi för hudcancer, mottar han den prestigefyllda utmärkelsen v

https://www.medicin.lu.se/artikel/melanomforskaren-goran-jonsson-utsedd-till-arets-cancerforskare - 2024-12-26