Published 10 September 2009 The risk of becoming obese is 2.5 times higher for those who have double copies of the best known risk gene for overweight and obesity. However, this is only true if the fat consumption is high. A low fat diet neutralizes the harmful effects of the gene. “This means that the critical factor is what you eat. At least in the case of the FTO gene, the most important obesit

https://www.ludc.lu.se/article/food-habits-are-more-important-most-important-obesity-risk-gene - 2025-02-09

Published 7 October 2009 Type 2 diabetes is often not caused by a lack of insulin per se, but an inability of the beta cells to secrete adequate amounts of it. Recently, scientists at LUDC have identified a previously unknown agent that plays an important role in the release of insulin. Knock-out mice that lack the ClC3 protein have a severely diminished capacity to secrete insulin in spite of int

https://www.ludc.lu.se/article/happy-insulin-cell-needs-be-sour - 2025-02-09

Published 11 December 2009 Children participating in the DiPiS and TEDDY studies, who are at high risk of developing type 1 diabetes, have the possibility to receive GAD vaccine. The hope is that this will stop the process and prevent the children from falling ill. Some of the children who have an increased risk of type 1 diabetes start producing antibodies directed at the insulin producing cells.

https://www.ludc.lu.se/article/vaccine-offered-children-i-skania-sweden-high-risk-diabetes - 2025-02-09

Published 23 November 2009 The finding of a new genetic risk variant and the description of the exact underlying mechanism explains, on a molecular level, the connection between stress and diabetes. This scientific breakthrough is published online today in the journal Science. Carriers of the risk variant have stressed insulin producing cells which greatly reduces their ability to secrete insulin.

https://www.ludc.lu.se/article/risk-gene-activates-stress-system-and-increases-risk-diabetes - 2025-02-09

Published 7 December 2009 Hyperglycemia starts a complex chain of events that damages blood vessels and cause cardiovascular disease. Scientists at Lund University Diabetes Centre (LUDC) have now been able to demonstrate why this happens, as well as how the destructive chain can be broken. This discovery represents a crucial step towards an efficient treatment of the vascular injuries that will be

https://www.ludc.lu.se/article/new-mechanism-underlying-cardiovascular-disease - 2025-02-09

Published 1 February 2010 Leif Groop, professor in diabetes and endocrinology at the Department of Clinical Sciences in Malmö, Lund University, has been elected to recipient of Hilda och Alfred Erikssons prize of year 2010. Leif Groop receives the prize "for pioneering research about Type 2 Diabetes" whcih is the motivation by the Academy of Science.- An honorable acknowledgement  and it is always

https://www.ludc.lu.se/article/royal-academy-science-praise-diabetes-professor - 2025-02-09

Published 16 February 2010 A recently discovered estrogen receptor in the insulin-producing cells may facilitate targeted diabetes treatment for women. The type 2 diabetes drugs that are currently available on the market have often only been tested on men. The identification of this new receptor may also explain why type 2 diabetes is less common in women than in men. "Estrogen is thought to have

https://www.ludc.lu.se/article/female-hormone-protects-against-diabetes - 2025-02-09

Published 25 March 2010 Children of immigrants from countries with low risk of type 1 diabetes develop the disease more often than expected if they grow up in Sweden, which is a high-risk country. Scientists mean that it is something in the Swedish environment that causes this elevated risk. Ahmed Delli, who is a scientist at Lund University Diabetes Centre, has mapped what happens when a child mo

https://www.ludc.lu.se/article/moving-sweden-increases-risk-diabetes - 2025-02-09

Published 26 March 2010 Anders Rosengren, physician at Skåne University Hospital and researcher at Lund University Research Centre in Malmö, has received six and a half million swedish crowns from the Novo Nordisk Foundation Project of Excellence. - This means a lot. I can start a research group of my own and drive the research work faster, says Anders Rosengren.The project he presented and, in to

https://www.ludc.lu.se/article/large-research-grant-mapping-linkage-between-stress-and-diabetes - 2025-02-09

Published 8 April 2010 At the time of the atmospheric nuclear weapons testing in the 1950s and 1960s, the level of carbon-14 in the atmosphere increased dramatically. Now researchers from Lund University have developed a method for measuring the carbon-14 content in atherosclerotic plaques in patients. The measurements reveal how old and dangerous the plaques really are. "On the one hand it’s impo

https://www.ludc.lu.se/article/nuclear-weapons-tests-provide-information-dangerous-atherosclerosis-plaque - 2025-02-09

Published 19 April 2010 All diabetics who developed the disease before the age of six months should be tested for a certain genetic mutation. Some of them might not need insulin injections but could manage their disease just as well, or better, with a simple tablet. “Neonatal diabetes is an uncommon form of diabetes caused by a genetic mutation, which means that insulin is not secreted in the righ

https://www.ludc.lu.se/article/many-diabetics-could-manage-without-insulin-injections - 2025-02-09

Published 10 June 2010 A prestigious award to Olle Melander, researcher at Lund University Diabetes Centre and physician at Skåne University Hospital in Malmö. He is awarded the prestigious award Peter Sleight Award 2010. The award, which is handed out by the European Society of Hypertension, consists apart from the honor, also by 10.000 euro.- It is of course very honorable to get appreciation fo

https://www.ludc.lu.se/article/prestigious-award-cardiovascular-research - 2025-02-09

Published 17 June 2010 During regulation of blood glucose levels, various hormones interact and counteract with each other in a complex manner. Together, these hormones maintain stable glucose levels. The recent mapping of hormonal interactions, carried out by scientists at Lund University Diabetes Centre (LUDC), aimed to explain why an imbalance occurs and to increase our understanding of the cau

https://www.ludc.lu.se/article/stable-glucose-levels-are-result-complex-hormonal-balancing-act - 2025-02-09

Published 6 August 2010 For the first time, scientists are able to describe the exact mechanism for how a common genetic variant leads to a disruption in blood lipid levels that significantly increases the risk of heart disease. The one in every three persons who carries both copies of the risk allele engages a 40 percent higher risk of suffering a heart attack than persons who do not carry either

https://www.ludc.lu.se/article/mechanism-behind-common-heart-attack-gene-explained-scientific-breakthrough-nature - 2025-02-09

Published 20 August 2010 As a PhD student he made a significant discovery when he identified ghrelin cells in the pancreatic islands. Four hormone-producing cells were already known to exist in the islands, including the insulin cell. The ghrelin cell became the fifth such cell. “In the scientific world, the discovery of a new type of cell in a human organ is a big deal. So naturally this was an i

https://www.ludc.lu.se/article/flying-start-fifth-cell - 2025-02-09

Published 15 February 2009 In competition with more than a thousand entries for the Presidential Poster Competition at the 2010 Endocrine Society congress in San Diego, USA, the winning contribution was that of Rajesh Kumar, scientist at Lund University Diabetes Centre. The research in question relates to the positive effects of the oestrogen hormone on the survival rates of insulin cells. Rajesh

https://www.ludc.lu.se/article/oestrogen-protects-transplanted-cells-and-organs - 2025-02-09

Published 6 September 2010 The goal is set high, that during the coming ten years develop new methods to prevent, cure and treat diabetes. - Ambitious, but not unrealistic, says Leif Groop, coordinator for EXODIAB, the joint research project that Lund and Uppsala now will launch with a conference in Malmö September 9-10th. Wide range and conductingEXODIAB (Excellence Of Diabetes Research in Sweden

https://www.ludc.lu.se/article/kick-large-venture-diabetes-research - 2025-02-09

Published 9 September 2010 Marju Orho-Melander, professor of genetic epidemiology in Malmö, has been awarded Lund University’s Fernström prize. Her research is about genetic variants that are associated with blood lipids and lipoproteins and can therefore increase the risk of cardiovascular disease. Many genes exist in different variants. Sometimes, some of the variants have a negative effect, in

https://www.ludc.lu.se/article/lunds-fernstrom-prize-goes-research-genes - 2025-02-09

Published 22 October 2010 Leif Groop, professor in diabetes and endocrinology at Lund University Diabetes Centre and consultant at the Endocrinological Department at Skåne University Hospital Malmö, has been elected to the diabetologist of the year by the Swedish Society of Diabetology. - I am of course honored and happy that my work is appreciated, comments Leif Groop.In the motivation for the ap

https://www.ludc.lu.se/article/leif-groop-diabetologist-year-2010 - 2025-02-09

Published 25 October 2010 An extensive global gene-mapping project has identified a large number of loci that dictate whether a person is tall or short. The aim of the project is to find out more about how many genes interact to form biologically interesting mechanisms behind diseases. "Height on its own is perhaps not tremendously interesting but it serves as a good indicator when determining how

https://www.ludc.lu.se/article/height-study-casts-light-genetic-mechanisms - 2025-02-09