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Epilepsy affects a significant portion of people worldwide and still requires alternative treatments due to resistance to anti-seizure medications. Gene therapy offers a promising alternative with several targets already established. Of these, glial cell line-derived neurotrophic factor (GDNF) and its receptor GFR⍺1 are well recognised for their roles in enhancing inhibitory signalling and support
ADAR1 as a Therapeutic Target in Prostate Cancer Prostate cancer is the second most common cancer and a leading cause of cancer-related deaths in men. While early-stage prostate cancer can be managed effectively, once it spreads, treatment options are limited and usually not curative. Immunotherapy, which boosts the immune system to fight cancer, has been effective in some cancer types but not in
Can Lin28b treat childhood leukemia? B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is one of the more common types of cancer in children. This disease originates mainly from progenitors of a white blood cell type known as the B-cell. Mature B-cells are mainly known for helping us clear infections by producing pathogen-binding antibodies. Because BCP-ALL cancer cells stem from B-cell pre
Vad kan stoppa mördarbakterierna? Varje år insjuknar tusentals svenskar i infektioner orsakade av bakterien Streptococcus pyogenes, även känd som grupp A-streptokocker. För de allra flesta yttrar sig detta som en ofarlig halsfluss som går över av sig själv eller med hjälp av antibiotika. Men för en liten andel leder det till allvarliga tillstånd såsom septisk chock och vävnadsnekros som i vissa f
Hur Påverkar Fosterutvecklingens Miljö Uppkomsten av Barncancer Neuroblastom är en aggressiv barncancer som uppstår under fosterutvecklingen när det sympatiska nervsystemet skapas, under fosterutvecklingen. Sympatiska nervsystemet kommer från neurallistceller, som vandrar ut i fostret och bildar olika celltyper. Tidigare forskning har visat att neuroblastom består av två huvudsakliga celltyper: m
The European Society for Clinical Evaluation of Balance Disorders (ESCEBD), based in Nancy, France, has been meeting yearly since 2005 to discuss equilibrium-related themes that are not yet clearly defined or standardized. One of our latest discussions was with regard to outlining strategies of internal and external compensation that may be used to cope with balance disorders. A Committee was elec
While NH3 has gained a lot of interest as a potential carbon-free fuel, at present, there are notable disagreements when it comes to predictions of some of its combustion characteristics, such as burning velocity or species mole fractions, in particular of NOx, which have the potential to cause significant harm to both human health and the environment. Nevertheless, because the NH3 flame presents
Nearly 40 % of individuals will be diagnosed with cancer in their lifetime, translating to an estimated 20 million new cases annually. Despite remarkable therapeutic advances, only 15–20 % of patients achieve durable responses to immunotherapy, and the high cost of treatment (illustrated by immune checkpoint inhibitors like pembrolizumab and nivolumab, totaling roughly $191,000 per year) remains a
Phytoplankton employ a wide variety of defenses to reduce mortality from zooplankton grazing. Many such defenses are inducible, that is, they are upregulated in the event of increased predation. Thus, theory predicts that they should come at a cost to the organism. When exposed to predatory cues from a copepod predator, the diatom Pseudo-nitzschia seriata upregulates the production of the neurotox
Foraging in landfills enhances the probability of acquiring antimicrobial resistance (AMR) in wildlife and increases exposure to pollutants like metal(loid)s, pharmaceuticals and caffeine. Exposure to metal(loid)s in the environment may cause selective pressure on bacteria, inducing metal resistance genes that drive antimicrobial resistance genes (ARGs) through co-resistance and cross-resistance m
This meta-review evaluated the possibility of more specified recommendations in antibiotic treatment through a narrowed focus on facial trauma. The aim was to analyze the effect of different regimens of antibiotic in treatment of skeletal trauma to the face. The knowledge mapping was based on existing systematic reviews (SRs) on trials specified in a PICO: Participants (P): Adults and children, di
Background: Studies on long-term exposure to air pollution at high levels suggest an association with increased risk of metabolic syndrome (MetS). We aimed to study this relationship at very low levels, less well-studied, yet of public health importance. Methods: The Swedish CArdioPulmonary bioImage Study (SCAPIS) consists of randomly selected subjects aged 50–64 years from six large cities in Swe
The present work presents extinction strain rates in both premixed and non-premixed cases for n-heptane flames, simulated with different transport formulations and a range of Lennard-Jones parameter sets. Although mixture-average and multi-component transport formulations give similar results, the inclusion of thermal diffusion has a larger impact. Thermal diffusion creates an accumulation of n-he
In the scholarly literature on the geography of transitions, the global innovation systems framework has been used to understand how system resources—such as knowledge, legitimacy, markets, and financial investments—are linked across various geographical scales, contributing to the emergence and performance of an innovation system within a distinct technological field. In this paper, we further de
A global larger foraminiferal turnover (LFT), first identified in the Pyrenees in 1960, occurred around the Paleocene-Eocene boundary. It is characterized by the replacement of Paleocene assemblages dominated by Glomalveolina and Lockhartia (west and east Tethys, respectively), with others typified by Eocene Alveolina and Nummulites. Its relationship with the Paleocene-Eocene Thermal Maximum (PETM
Flame spread through ventilation cavities in timber facades is a serious fire safety concern in tall buildings. In this study, flame behaviour inside a particleboard cavity, resembling the ventilation cavity in a façade system, was investigated. Experiments were conducted with particleboard on one side and an inert panel on the other, across six cavity widths ranging from 10 cm to 25 cm. Variation
