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Amyloid fibrils are highly insoluble in neutral aqueous media of regular ionic strengths making solubilization a difficult task that normally calls for extremely harsh treatment. This is among the reasons for the routine employment of synthetic proteins in amyloid research, where the amylogenic components are needed. Here we describe a process for solubilizing amyloid in pure water that we adopted
Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of amyloid within arteries of the cerebral cortex and leptomeninges. This condition is age related, especially prevalent in Alzheimer's disease (AD) and the main feature of certain hereditary disorders. The vascular smooth muscle cells (VSMC) appear to play a vital role in the development of CAA and have been found to produce t
This paper aims to explore how four Bolivian small and medium-sized enterprises’ business has overcome the gaps in reliance on traditional small and medium-sized enterprises’ business models, i.e., to extract and sell raw unrefined natural resources in a local area, and instead make productive use of innovation inputs (technology, higher-educated people) by innovating their business models. We wer
The broad goal of this thesis is to develop a deeper mathematical understanding of the processes at work in the neuronal network of a brain by rigorously examining very fundamental elements of the processes involved. Paper I considers the flow of discrete signals on a graph and Paper II the complexity arising from the interplay of simple units. The concrete probabilistic investigations of such mod
This chapter analyzes five cases in which the Turkish Constitutional Court banned political parties, advocating for equal citizenship rights for the Kurdish people, based on their alleged violation of the law on political parties, which prohibits claims of the existence of minorities. The chapter aims to explore the conceptualization of minority rights within the juridico-political realm of Turkey
The Long-Term Global Goal (LTGG) is the focal point for addressing future climate change. This paper explores a specific institutional context: the Structured Expert Dialogue (SED) of the UN Framework Convention on Climate Change (UNFCCC). Set up as a platform for interaction between experts and UN negotiators, the SED is a site where scientific information about the LTGG and net-zero was translat
The Øresund Fixed Link is a 15,9 km road and railway connection between the southerly Swedish city of Malmö and its neighbor across the Øresund strait, Copenhagen, in Denmark. The link, which opened in 2000, consists of an elevated bridge, including a high stay cable bridge, an artificial island, as well as a submerged tunnel. The operators of the link, Øresundsbron Consortium, have recently, as p
Operating enormous, integrated refineries and clusters, the petrochemical industry runs processes in which hydrocarbons are turned into the fundamental components for plastics and other synthetic materials. Continuing a historical trend of consistent output growth, petrochemicals are the largest current driver of oil demand growth. At the same time, the industry is under increasing pressure to tra
This article analyses actor relationships in Transit Oriented Development (TOD) planning in order to better understand the preconditions necessary for planning processes to result in TOD in lower density contexts, in suburbs, or small cities. Empirically, the analysis builds on a comparative case study of TOD planning projects. The focus in the analytical work is on understanding how market condit
In recent years laser driven attosecond sourcesAttosecond sources based on loose geometry high order harmonic generationHigh order harmonic generation reach focused intensities as high as to induce multi-photonMulti-photonmultiple ionizationMultiple ionization or even strong -field effectsEven strong-field effects in the extreme ultraviolet spectral range. In this chapter, we review four such sour
The habitual consumption of snacks has the potential to enrich or harm the diet. They can contribute to excessive caloric intake and hyperglycemia. Thus, there is an increasing interest in snacks with health-promoting properties. This study aimed to demonstrate the beneficial effect of two fruit-based bars on glucose levels through in vitro, in vivo, and in silico assays. Mango (Mangifera indica L
In recent years the thermal extremes have become increasingly severe, and it is expected that hot extremes will become twice as frequent if we are unable to limit global warming. The global warming will increase the available energy in certain weather systems making hurricanes more easily reach the development threshold and the increased displacement of precipitation will cause longer and more int
This paper examines the effects of short-term economic stress, captured by general price volatility and a negative wealth shock on short-run fertility behavior in the rural pre-transitional society of the Cape Colony. First, we link complete birth histories of settler women from the South African Families database to consumer price index data to examine the effect of price volatility on conception
Over the past couple of decades, considerable advances in automation and high-throughput omics technologies have contributed to the generation of unprecedented amounts of molecular data, challenging the traditional “one size fits all” approach in favour of personalised medicine, where the individual needs of patients are addressed.However, the speed at which such molecular data is being acquired d
