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Tau hyperphosphorylation, a key neuropathological feature of tauopathies such as Alzheimer’s disease (AD), also occurs physiologically during mammalian hibernation and is fully reversed upon arousal, offering a unique translational model to study tau metabolism. However, limited data exist on insoluble and soluble tau alterations during hibernation and on patterns of tau fragment concentrations in
Although organizational innovation capability plays a driver for the improvement of safety performance of High Reliability Organizations (HRO), knowledge management is a key link and important guarantee for them. However, there is no relevant research on how to achieve innovation of HRO through knowledge management. Previous research highlights that the dynamic and uncertain external environment o
The preparation of ultra-thin PtSn-alloyed layers by molecular beam epitaxy was studied using low-energy electron microscopy (LEEM) and micro-diffraction (μ-LEED). Deposition at a sample temperature of 435 °C initially results in the formation of a Pt3Sn/Pt(111) layer showing a (2 × 2) reconstruction. With continued Sn deposition, a Pt2Sn/Pt(111) layer develops, showing a (3×3)R30° reconstruction.
Co-speech head and eyebrow gestures often align with pitch accents in spoken language production, thereby likely instantiating what we could refer to as multimodal prominence. Indeed, when speech is perceived audio-visually, controlled experimental studies have shown that both pitch accents and head and eyebrow gestures, when independently manipulated, have sizable effects on perceived prominence.
Rhesus macaques (RMs) are a vital model for studying human disease and invaluable to pre-clinical vaccine research, particularly for the study of broadly neutralizing antibody responses. Such studies require robust genetic resources for antibody-encoding genes within the immunoglobulin (IG) loci. The complexity of the IG loci has historically made them challenging to characterize accurately. To ad
Capacities for source localization in response to incidents involving radioactive materials are essential for effective, efficient response. In this context, the directional response of a detection system is of importance. Many solutions currently employed for source localization involve approaches that may be onerous with respect to cost, complexity and practicality for field operations. To avoid
Objectives: The objective was to explore if adverse events during radical prostatectomy for prostate cancer were associated with oncological outcomes. A further objective was to identify risk factors for adverse events. Methods: A post-hoc study nested in a prospective, controlled trial of radical prostatectomy by robot assisted laparoscopic or open retropubic approach in Sweden. Adverse events du
The IFMIF-DONES facility provides a very high intensity flux of neutrons for research on materials of future fusion reactors and other complementary applications. The generation of those neutrons is driven by stripping reactions between energetic deuteron particles and a liquid lithium jet. The requirements on the deuteron beam are to deliver a 40 MeV beam with a constant current of 125 mA. All th
Multiple cropping, the simultaneous cultivation of several crops in space or time, is a global practice essential for intensifying and diversifying agriculture. Despite its substantial impact on environmental and socioeconomic outcomes of farming, multiple cropping is hardly accounted for in assessments of global food production, sustainability, and climate impacts. Such studies, often relying on
Pancreatic cancer continues to be a major cause of cancer deaths worldwide. Characterizing the tumors of long-term survivors (≥5 years survival) would create opportunities in prognostic and therapeutic strategies. In this study, RNA sequencing data was used to identify differentially expressed genes (DEGs) in tumors of long-term survivors (LTS) vs short-term survivors (STS). Using LASSO-Cox regres
Recent self-reported and cross-sectional survey evidence documents high levels of mental health problems among PhD students. We study the relationship between PhD studies and mental health care utilization using Swedish administrative records of prescriptions for psychiatric medication for the full population of PhD students. We find that prior to starting their PhD studies, prospective students u
Objective: Drug-coated balloons (DCB) might improve the results of below the knee (BTK) angioplasty, but sufficient randomized data comparing DCB and conventional angioplasty in treating patients with chronic limb threatening ischemia (CLTI) are lacking. This study aimed to perform a randomized comparison between a paclitaxel-coated angioplasty balloon catheter and a conventional balloon angioplas
BackgroundThe captive bolt gun is a tool for stunning animals in the meat industry and is not considered a firearm under the Swedish firearm legislation. This study aimed to explore the involvement of such devices in human fatalities, with an emphasis on suicides. Epidemiological characteristics from a longitudinal perspective, as well as risk factors and injury patterns were analyzed.MethodSuicid
The incentive for this chapter emerged in the beginning of the pandemic when we collected data for a comparative research project in three countries whose strategies to combat the COVID-19 virus were strikingly different and often debated: Sweden, Italy, and the United States. Trying to make sense of our subjective feelings as well as the collective feelings we identified in reports and discussion
Para athletes are at higher risk for sports-related injuries, illnesses and other health conditions when participating in sports. In fact, the unique demands placed on Para athletes, both in terms of the specific impairments they experience and the adaptive equipment they use, can lead to a distinctive set of challenges and risks in the context of sports-related health compared to nondisabled athl
