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Background: In chronic pulmonary diseases characterized by inflammation and airway obstruction, such as asthma and COPD, there are unmet needs for improved treatment. Quinolines is a group of small heterocyclic compounds that have a broad range of pharmacological properties. Here, we investigated the airway relaxant and anti-inflammatory properties of a novel quinoline (RCD405). Methods: The airwa
At Lund University and Skåne University Hospital in Lund, Sweden, we have, as the first clinic, modified a clinical Elekta Precise linear accelerator for convertible delivery of ultrahigh dose rate (FLASH) irradiation. Whereas recently published reviews highlighted the need for standardised protocols for ultra-high dose rate beam dosimetry to be able to determine the true potential of FLASH irradi
Highly anisotropic cellulose nanofibrils can solidify liquid water, creating self-supporting structures by incorporating a tiny number of fibrils. These fibrillar hydrogels can contain as much as 99.99 wt% water. The structure and mechanical properties of fibrillar networks have so far not been completely understood, nor how they solidify the bulk water at such low particle concentrations. In this
Small-angle X-ray scattering (SAXS) is used to demonstrate the presence of density fluctuations in ambient water on a physical length-scale of ≈1 nm; this is retained with decreasing temperature while the magnitude is enhanced. In contrast, the magnitude of fluctuations in a normal liquid, such as CCl 4, exhibits no enhancement with decreasing temperature, as is also the case for water from molecu
We consider linear mappings on the 2-dimensional torus, defined by T ( x ) = A x ( mod 1 ) , where A is an invertible 2 × 2 integer matrix, with no eigenvalues on the unit circle. In the case det A = ± 1 , we give a formula for the Hausdorff dimension of the set { x ∈ T 2 : d ( T n ( x ) , x ) < e − α n for infinitely many n } .
The Events Research Programme (ERP) was a multi-disciplinary study undertaken during the COVID-19 pandemic to investigate SARS-CoV-2 transmission risks and mitigations around the reopening of mass events in the UK in 2021 – including a behavioural study, exploring how non-pharmaceutical interventions (NPIs), such as social distancing, pre-event virus testing, and the use of face coverings might en
In 1689 the Danish royal antiquary Thomas Bartholin the Younger (1659–1690) published a celebrated antiquarian work on the attitudes, customs, and rituals of the pagan inhabitants of Scandinavia. It has been deemed significant both for influencing the development of the historical conception of the ‘Viking Age’ in the eighteenth and nineteenth centuries, and for introducing a rigorous source-criti
Den här avhandlingen analyserar en korpus av publicerade personliga brev från första halvan av 1900-talet skrivna av manliga författare från Marocko och Tunisien. Studiens övergripande syfte är att undersöka och identifiera de publicerade brevens litterära egenskaper (genius) och estetiska autonomi (egenvärde) med hjälp av en narratologisk och stilistisk metod som fokuserar påintertextualitet och This dissertation deals with a corpus of published private letters from the first half of the 20th century written by male writers from Morocco and Tunisia. The overall purpose of the study is to investigate and identify the literary properties (literary genius) of the published letters and their aesthetic autonomy using a stylistic and narratological method that focuses on intertextuality and the
The case presents Aboke-pesa, a local complementary currency in a poor rural area of Western Kenya.The reader gets an insight into the economic context of rural areas in the Global South, the work of introducing digital community currencies through farmers’ cooperatives, one of the most common designs of these currencies (mutual credit systems or LETS) as well as the particular challenges digital
A note with instructions for teaching the case with the same title.
Allergic contact dermatitis is reported among individuals using continuous glucose monitoring systems and insulin pumps. The aim of this study was to describe contact allergy patterns for allergens in the Swedish baseline series and medical device-related allergens among users. Contact allergy to baseline series allergens and isobornyl acrylate was compared between diabetes patients and dermatitis
Hemolysis is a cardinal feature of hemolytic uremic syndrome (HUS) and during hemolysis excess arginase 1 is released from erythrocytes. Increased arginase activity leads to reduced arginine, as it is converted to urea and ornithine, and thereby reduced nitric oxide bioavailability, with secondary vascular injury. In this study we investigated arginase release in HUS patients and laboratory models
Aim: How the ability of plants to move towards newly favourable habitats (dispersal limitation) impacts the change of biome distribution and transition under fast climate warming is still debated. Analysing vegetation change in the past may help to clarify the relative importance of underlying ecological processes such as climate, biotic interactions, and dispersal. In this study, we investigated
Syftet med detta bidrag är alltså att kritiskt granska äldres rätt till fri rörlighetinom EU. Utgångspunkten för denna analys är artikel 3 FEU där centralavärden för EU såsom välfärd, fri rörlighet, icke-diskriminering, socialrättvisa, socialt skydd och jämställdhet mellan kvinnor och män betonas.Vårt bidrag i detta kapitel är att visa att såsom reglerna är utformade idagriskerar de att ha en kraf
Background & aim: Clinical trials supplementing the long-chain polyunsaturated fatty acids (LCPUFAs) docosahexaenoic acid (DHA) and arachidonic acid (AA) to preterm infants have shown positive effects on inflammation-related morbidities, but the molecular mechanisms underlying these effects are not fully elucidated. This study aimed to determine associations between DHA, AA, and inflammation-r
OBJECTIVE: The authors sought to clarify the components of the familial liability to alcohol use disorder (AUD) by examining parent-offspring transmission in a large Swedish population sample. METHODS: To this end, 1,244,516 offspring in intact families with a mean age at follow-up of 37.7 years (SD=6.8) were examined. Hazard ratios for offspring of parents with AUD were calculated using Cox model
The central complex (CX) is a highly conserved region of the insect brain, and its ubiquitous occurrence suggests that its neural circuits are of fundamental importance. While its overall layout has not changed since the evolution of insect flight, substantial variations exist in the internal organization of all CX components. By changing the details of a system of repeating columns and layers, th
Aim: Ultraviolet B (UVB) radiation can compromise the functionality of the skin barrier through various mechanisms. We hypothesize that UVB induce photochemical alterations in the components of the outermost layer of the skin, known as the stratum corneum (SC), and modulate its antioxidative defense mechanisms. Catalase is a well-known antioxidative enzyme found in the SC where it acts to scavenge
We give a complete proof of the classical Benjamin and Lighthill conjecture for arbitrary two-dimensional steady water waves with vorticity. We show that the flow force constant of an arbitrary smooth solution is bounded by the flow force constants for the corresponding conjugate laminar flows. We prove these inequalities without any assumptions on the geometry of the surface profile and put no re
