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Pseudouridine synthases (PUSs) catalyze the isomerization of uridine (U)-to-pseudouridine (Ψ) and have emerging roles in development and disease. How PUSs adapt gene expression under stress remains mostly unexplored. We identify an unconventional role for the Ψ "writer" PUS10 impacting intracellular innate immunity. Using Pus10 knockout mice, we uncover cell-intrinsic upregulation of interferon (I
Japan's January withdrawal of funding from the UN Committee on the Elimination of Discrimination against Women highlights its aversion to addressing gender equality issues at home. Despite externally presenting a commitment to progressive gender norms, a tension between Japan's international image and its domestic reality persists. Japan continues to rank low in major gender equality indexes as re
In times of heightened dissensus over the liberal democratic order, normative theories of the EU need to adapt to be able to capture how the promotion and enforcement of values go hand in hand with their contestation. Research on global LGBT politics has shown that the promotion and enforcement of LGBT equality make possible and shape the anti-LGBT dissent it seeks to combat. Understood as a parad
This presentation focuses on a project at an early stage of development. The aim of the practice lab project is twofold: (i) to strengthen the competence among students in higher music education with regards to the topic of practice, and (ii) contribute to research on musical practice and skill acquisition. The project is conducted at Malmö Academy of Music (Lund university). Students take part in
Recent years has seen a number of music researchers taking interest in the concept of affordances. Although interpretation of the concept varies, a common denominator is that affordances are opportunities for actions emerging between a subject and the environment. As such, it is an analytical perspective that highlights material and embodied dynamics of musical practice, dimensions central to musi
OBJECTIVES: The Apollo study was designed to support the clinical performance verification of the adjusted cutoffs of the Elecsys® β-Amyloid(1-42) (Aβ42) cerebrospinal fluid (CSF) II, β-Amyloid(1-40) (Aβ40) CSF, Phospho-Tau (181P) (pTau) CSF and Total-Tau (tTau) CSF immunoassays (Roche Diagnostics International Ltd) for measuring fresh CSF samples, and assess the concordance of the Elecsys CSF pTa
The Swedish particle så is attested in different usages. In one of these, så introducesassertive clauses forming the foreground, or the skeleton, of a narrative. It is argued that, ifthe distribution of this particular particle is to be captured in a theory of syntax, such atheory needs to incorporate notions relating to narrative discourse or, in other words, atheory in which grammatical statemen
IMPORTANCE: Life expectancy is a composite health measure reflecting acute and life-course exposures. Identifying conditions behind disparities in life expectancy can guide policy, planning, and financing to battle the most urgent health problems.OBJECTIVE: To examine the contribution of 33 causes of death to life expectancy disparities, highlighting 2 sets of priority conditions-8 infectious and
Objective: The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides are heterogeneous disorders. The aim of this study was to identify and characterize subgroups of patients based on sex, ANCA, age at diagnosis, and organ involvement. Methods: In total, 1,167 patients with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) were retrospectively recruited to the s
PURPOSE: Early identification of the underlying cause of intracerebral hemorrhage (ICH) is important for treatment and prognosis. This study aims to investigate the association of hematoma volume and other clinical parameters on the distribution of cerebral amyloid angiopathy (CAA) probability according to the simplified Edinburgh CT criteria in a large, unselected intracerebral hemorrhage (ICH) p
In scenarios coined Maxwell's demon, information on microscopic degrees of freedom is used to seemingly violate the second law of thermodynamics. This has been studied in the classical as well as the quantum domain. In this paper, we study an implementation of Maxwell's demon that can operate in both domains. In particular, we investigate information-to-work conversion over the quantum-to-classica
BackgroundComorbidity burden may affect the outcome following endovascular thrombectomy (EVT) for medium‐vessel occlusions. Since patients with high comorbidity burden are likely to be underrepresented in trials on EVT for medium‐vessel occlusions, observational data are needed to assess the benefit of EVT for these patients.MethodsWe conducted an observational study on all prestroke independent p
Objective: Following the favorable outcomes demonstrated by the Early MiNimally-invasive Removal of IntraCerebral Hemorrhage (ENRICH) trial in supratentorial intracerebral hemorrhage (ICH) patients treated with minimally invasive surgery (MIS), and considering the increasing interest in MIS, we aimed to assess the potential eligibility rate for ICH patients in Sweden. Methods: All patients with sp
This book examines how caseworkers are governed in today’s street-level bureaucracies. It redefines our understanding of public sector governance by highlighting the subtle, informal, and everyday forms of organizational governance that shape caseworkers’ subjectivities beyond formal policies and professional identities. Based on four distinct types of normative governance – ‘governance by discour
BackgroundEarly initiation of breastfeeding, defined as breastfeeding within one hour of birth, halves the risk of neonatal mortality, establishing it as a crucial outcome component in various interventions implemented across South Asian countries. However, the overall effect of these interventions remain unexamined. Therefore, this study seeks to address this knowledge gap by evaluating the overa
The structural evolution of molecular hydrogen H2 under multi-megabar compression and its relation to atomic metallic hydrogen is a key unsolved problem in condensed-matter physics. Although dozens of crystal structures have been proposed by theory1, 2, 3–4, only one, the simple hexagonal-close-packed (hcp) structure of only spherical disordered H2, has been previously confirmed in experiments5. T
Electrons photoemitted by extreme ultraviolet attosecond pulses derive spatially from the first few atomic surface layers and energetically from the valence band and highest atomic orbitals. As a result, it is possible to probe the emission dynamics from a narrow 2D region in the presence of optical fields, as well as obtain elemental specific information. However, combining this with spatially-re
Within the FLASH2020+ upgrade, the pump-probe laser capabilities of the extreme ultraviolet and soft x-ray free-electron laser (XFEL) FLASH in Hamburg will be extended. In particular, providing wavelength tunability, shorter pulse durations, and reduced arrival time jitter will increase the scientific opportunities and the time resolution for the XFEL-optical laser pump-probe experiments. We prese
A novel regularization method for shape optimization of contacting structures is proposed. The shape optimization avoids parameterizations via splines or the level set method by directly optimizing the nodes in the finite element mesh. In the past this approach was limited by numerical difficulties arising from mesh entanglement and serrated boundaries but recent advances in regularization techniq
