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Objective: To determine whether the comorbidity burden and co-existing comorbidities are cross-sectionally and/or longitudinally associated with pain and pain sensitization in a cohort study of people with hand OA. Design: We examined whether comorbidity burden and individual comorbidities based on the self-administered Comorbidity Index (range: 0–42) at baseline were associated with pain outcomes

Many patients with Parkinson's disease (PD) experiencing L-DOPA-induced dyskinesia (LID) receive adjunct treatment with dopamine agonists, whose functional impact on LID is unknown. We set out to compare temporal and topographic profiles of abnormal involuntary movements (AIMs) after L-DOPA dose challenges including or not the dopamine agonist ropinirole. Twenty-five patients with PD and a history

Numerous cost-optimal studies have been undertaken by EU member states to define minimum energy performance requirements for buildings within that member state in accordance with the Energy Performance of Buildings Directive. As few of these studies have examined the effect of heating and ventilation system parameters on life cycle cost (LCC) and energy use in detail, this paper analysed 84 HVAC s

The oxygen content of ancient seawater has been hypothesized to be a major controlling factor for biodiversity throughout Earth's history. The Great Ordovician Biodiversification Event (GOBE) represents one of the largest increases in biodiversity during the Phanerozoic, with peak rates of diversity occurring in the Middle–Late Ordovician. Multiple causal factors have resulted in this long-term ad

A cohesive interface model based on a master curve is proposed for the analysis of delamination in paperboard under various loading, unloading, and reloading conditions. The model is thermodynamically consistent and considers the effects of elasticity, plasticity, and damage. The proposed model is verified by comparing its predictions with experimental data obtained from multiple loading–unloading

Increased incidence of squamous cell carcinoma (SCC) of the tongue has been reported in young adults (YA) in several countries since the 1980s and confirmed in later studies. The etiology is unclear, the prognosis has been debated, and conflicting results have been published. Some studies show better survival in young adults than in older patients, some worse, and others no difference. Most studie

Glucagon is the principal glucose-elevating hormone that forms the first-line defence against hypoglycaemia. Along with insulin, glucagon also plays a key role in maintaining systemic glucose homeostasis. The cells that secrete glucagon, pancreatic α-cells, are electrically excitable cells and use electrical activity to couple its hormone secretion to changes in ambient glucose levels. Exactly how

The Amit conjecture about word maps on finite nilpotent groups has been shown to hold for certain classes of groups. The generalised Amit conjecture says that the probability of an element occurring in the image of a word map on a finite nilpotent group G is either 0, or at least 1/|G|. Noting the work of Ashurst, we name the generalised Amit conjecture the Amit–Ashurst conjecture and show that th

Background: Human chorionic gonadotropin (hCG) is produced by the placenta and plays an essential role in the maintenance of pregnancy. Endocrine disrupting chemicals (EDCs) have the potential to interfere with functions related to the production and secretion of hCG; however associations between exposure to EDCs and hCG concentrations in humans remain to be elucidated. Objectives: To investigate

The solubilisation capacities of the micelles formed by a range of surfactants possessing a dodecyl (C12) hydrocarbon ‘tail’ and a variety of hydrophilic ‘headgroups’ have been studied for a range of hydrophobic steroids (testosterone (T) and its propionate (TP) and enanthate (TE) esters). The solubilisation studies were performed at ambient temperature, with drug concentration monitored (over 48–