As alterations in tissue pH underlie many pathological processes, the capability to image tissue pH in the clinic could offer new ways of detecting disease and response to treatment. Dynamic nuclear polarization is an emerging technique for substantially increasing the sensitivity of magnetic resonance imaging experiments. Here we show that tissue pH can be imaged in vivo from the ratio of the sig

In this work, we introduce a computationally efficient multi-pitch estimation algorithm making use of an approximative frequency domain reformulation of a recent block-sparse multi-pitch estimator. Different to most other pitch estimators, the proposed method does not require a prior knowledge of the number of sources present, nor the number of overtones of each such source. Evaluated on measured

Socioeconomic status-related factors have been associated with access to kidney transplantation, yet few studies have investigated both individual income and education as determinates of access to kidney transplantation. Therefore, this study aims to explore the effects of both individual income and education on access to kidney transplantation, controlling for both medical and non-medical factors

PURPOSE:: To investigate how patients with neovascular age-related macular degeneration treated with ranibizumab or bevacizumab respond to treatment in daily clinical practice. METHODS:: Data from the Swedish Macula Register on the treatment received by 3,912 patients during 2011 to 2014 is reported. Patientsʼ characteristics at the first visit, visual acuity, number of injections, and reason for

Human actions have led to loss and degradation of wetlands, impairing their suitability as habitat especially for waterbirds. Such negative effects may be mitigated through habitat management. To date scientific evidence regarding the impacts of these actions remains scarce. We studied guild specific abundances of breeding and staging birds in response to habitat management on 15 Finnish wetlands.

Employing fault tolerance often introduces a time overhead, which may cause a deadline violation in real-time systems (RTS). Therefore, for RTS it is important to optimize the fault tolerance techniques such that the probability to meet the deadlines, i.e. the Level of Confidence (LoC), is maximized. Previous studies have focused on evaluating the LoC for equidistant checkpointing. However, no stu

Traumatic brain injury (TBI) is currently a major cause of morbidity and poor quality of life in Western society, with an estimate of 2.5 million people affected per year in Europe, indicating the need for advances in TBI treatment. Within the first 24 h after TBI, several inflammatory response factors become upregulated, including the lectin galectin-3. In this study, using a controlled cortical

Over the last decades, the impact of human activities on the global nitrogen (N) cycle has drastically increased. Consequently, benthic N cycling has mainly been studied in anthropogenically impacted estuaries and coasts, while in oligotrophic systems its understanding is still scarce. Here we report on benthic solute fluxes and on rates of denitrification, anammox, and dissimilatory nitrate reduc

Mitochondrial disease refers to a heterogeneous group of disorders resulting in defective cellular energy production due to dysfunction of the mitochondrial respiratory chain, which is responsible for the generation of most cellular energy. Because cardiac muscles are one of the high energy demanding tissues, mitochondrial cardiomyopathies is one of the most frequent mitochondria disorders. Mitoch

Automatic detection of point groups as well as symmetrisation of molecular geometry and wavefunctions are useful tools in computational quantum chemistry. Algorithms for developing these tools as well as an implementation are presented. The symmetry detection algorithm is a clustering algorithm for symmetry invariant properties, combined with logical deduction of possible symmetry elements using t

Many state-of-the-art multichannel speech enhancement methods rely on second-order statistics of the desired speech signal, the noise signal, or both. Estimation of those are difficult in practice, resulting in a practical performance that is typically much lower than their potential theoretical performance. We propose two multichannel enhancement techniques that instead rely on a model for voiced

This paper addresses reduction of test cost for core-based non-stacked integrated circuits (ICs) and stacked integrated circuits (SICs) by test planning, under power constraint. Test planning involves co-optimization of cost associated with test time and test hardware. Test architecture is considered compliant with IEEE 1149.1 standard. A cost model is presented for calculating the cost of any tes

The Univalent Foundations project constitutes what is arguably the most serious challenge to set-theoretic foundations of mathematics since intuitionism. Like intuitionism, it differs both in its philosophical motivations and its mathematical-logical apparatus. In this paper we will focus on one such difference: Univalent Foundations’ reliance on an intensional rather than extensional logic, throu

Should an inflation-targeting central bank have an explicit tolerance band around its inflation target? This paper provides an answer derived from the Swedish experience. The Riksbank is exceptional in the sense that it first adopted and later abolished an explicit band and is currently considering bringing it back. We conclude that the band should be explicit for several reasons. Most important, Should an inflation-targeting central bank have an explicit tolerance band around its inflation target? This paper provides an answer derived from the Swedish experience. The Riksbank is exceptional in the sense that it first adopted and later abolished an explicit band and is currently considering bringing it back. We conclude that the band should be explicit for several reasons. Most important,

Good communication is of utmost importance in all forms of cancer care and especially so in the palliative context. To render the ungraspable graspable, metaphors are frequently used drawing on their capacity to capture the intangible in terms of more familiar experiences. For instance, to die from cancer can be described as ’coming to the end of a life journey’ or ’losing a battle’. Metaphors are

The staphylococcal enterotoxin H (SEH; 217 aa, 25 kD) belongs to a family of superantigens that cause a massive immune response upon simultaneous binding to the T cell receptor (TCR) and the major histocompatibility complex class II. The SEH-TCR interaction is weak and amenable to studies using NMR methodology. Essentially, 2 mg of U{2H, 13C,15N}-labeled SEH was used for the complete sequential ba

This chapter sketches some of the societal dynamics that Gezi protests have expressed and the ways in which they constitute a significant departure from both the conceptualization and practice of politics in contemporary Turkey, through an interrogation of the politics of space that has occupied center stage in the protests.

Aim: To estimate the effects of targeted elimination of environmental barriers (EB) in the ordinary housing stock in Sweden, and to explore the estimated effects on accessibility at a population level in relation to (a) residents with different functional profiles, (b) different housing types and (c) building periods. Method: Data on dwellings from existing Swedish research databases were utilized

Model catalysts containing disordered CuO and ZnO species in the pores of SBA-15 were reduced under different conditions (standard: H2, 513 K; severe: CO/H2, 673 K), studied by X-ray diffraction (XRD) and X-ray absorption spectroscopy (XAS) including operando work and used as catalysts for methanol synthesis at pressures up to 8 bar, where they were comparable with a commercial reference in terms