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I can play! : digitally based musicking with children in need of special support : 32nd World Conference International Society for Music Education, Glasgow, UK

I Can Play! -– Digitally- based musicking with children in need of special supportThis presentation highlights preliminary results from an ongoing action research project in a Swedish primary school. The aim of the project is to develop and test digitally-based musical settings with young children in need of special support. Computers, iPads and synthesizers were used in order to facilitate for th

Narratives about music and health : The 22nd annual conference of the Nordic Network for Research in Music Education March 14-16 2017

Music is used in many professional contexts that are not associated, in a traditional sense, with either music therapy or music education. How do professionals in different contexts use music, and how do they describe their thoughts about music in their professional work? Those are the main questions in our inquiry, focusing on narratives about music and health in professional relations. In this p

Biallelic germline nonsense variant of MLH3 underlies polyposis predisposition

Purpose: Some 10% of familial adenomatous polyposis (FAP) and 80% of attenuated polyposis (AFAP) cases remain molecularly unexplained. We scrutinized such cases by exome-wide and targeted methods to search for novel susceptibility genes. Methods: Exome sequencing was conducted on 40 unexplained (mainly sporadic) cases with FAP or AFAP from Finland. The DNA mismatch repair (MMR) gene MLH3 (MutL Hom

Towards Noble-Metal-Free Dyads : Ground and Excited State Tuning by a Cobalt Dimethylglyoxime Motif Connected to an Iron N-Heterocyclic Carbene Photosensitizer

Heteroleptic iron based complexes bearing the 2,6-bis[3-(2,6-diisopropylphenyl)imidazol-2-ylidene]pyridine motif and a polypridine ligand have been synthesized and characterized in their ground and excited state. This series of complexes includes a first example of a hetero-bimetallic complex connecting an iron N-heterocyclic carbene photosensitizer with a cobalt dimethylglyoxime fragment. Focus i

Sequential fractionation of the lignocellulosic components in hardwood based on steam explosion and hydrotropic extraction

BackgroundThe forest biorefinery plays an important part in the evolving circular bioeconomy due to its capacity to produce a portfolio of bio-based and sustainable fuels, chemicals, and materials. To tap into its true potential, more efficient and environmentally benign methods are needed to fractionate woody biomass into its main components (cellulose, hemicellulose, and lignin) without reducing

Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology

The clustering of different types of B-cell malignancies in families raises the possibility of shared aetiology. To examine this, we performed cross-trait linkage disequilibrium (LD)-score regression of multiple myeloma (MM) and chronic lymphocytic leukaemia (CLL) genome-wide association study (GWAS) data sets, totalling 11,734 cases and 29,468 controls. A significant genetic correlation between t

Global trends in length of stay : implications for destination management and climate change

Length-of-stay (LOS) is a key parameter in destination management that determines the number of guest nights relative to arrival numbers, with concomitant repercussions for revenue generation and other performance indicators. This article investigates the development of LOS for 32 destinations in developed and emerging economies as well as Small Islands and Developing States (SIDS). The analysis i

The decarbonisation impasse : global tourism leaders’ views on climate change mitigation

The Paris Climate Agreement is based on pledges from 195 countries to substantially reduce emissions of greenhouse gases (GHG) to prevent dangerous climate change. The tourism sector has likewise pledged to reduce its GHG emissions (−70% by 2050); however, current emission trends would result in a tripling in the same timeframe. In order to understand how the sector understands the decarbonisation

The effect of multiple hydrotropic treatments on the delignification of hardwood

Hydrotropic extraction (HEX) is a method for the delignification of lignocellulose that has been given increasing amounts of attention during the last couple of years. A hydrotrope is an amphiphilic substance, which, in high enough concentrations, can improve solubility of otherwise poorly soluble substances in water. The most commonly used substance for HEX-delignification is sodium xylenesulfona

The effect of steam pretreatment on hydrotropic extraction of hardwood

The forest industry is one of Sweden’s most important business areas. As the use of paper is declining the need for this sector to find other alternatives is increasing. An attractive option to meet this demand is the establishment of forest biorefineries. However, economically suitable pretreatment methods for woody biomass, which minimize degradation of the structural carbohydrates and allow the

Meal frequency and vegetable intake does not predict the development of frailty in older adults

Background: Frailty is considered highly prevalent among the aging population. Fruit and vegetable intake is associated with positive health outcomes across the life-span; however, the relationship with health benefits among older adults has received little attention. Aim: The aim was to examine if a relationship exists between meal frequency or frequency of vegetable intake and the development of

Copper trade and production of copper, brass and bronze goods in the Oldenburg monarchy : copperworks and copper users in the eighteenth century

This paper explores trade connections – or the lack of such – between copperworks and copper processing plants in the Oldenburg Monarchy in the eighteenth century. Domestic customs areas, high tariffs on raw material export and import bans sought to encourage domestic copper and brass goods production of Norwegian copper raw material, however this was only realised halfway. The raw material from N

A combined approach to assess the impacts of Ecological Focus Areas on regional structural development and agricultural land use

The 2013 reform of the Common Agricultural Policy (CAP) introduced compulsory ‘greening’ measures with the goal to mitigate environmental degradation caused by intensive agriculture. This paper aims to investigate how the implementation of the Ecological Focus Areas (EFA) obligation will affect regional agricultural development, the economic performance of farms and land use (including choices of

Potential use of biomass for separation of lignin by hydrotropic extraction

The demand for energy in the world is increasing steadily. As the standard of living for people in the developing countries is increasing so is the net energy use per capita. The main contributor to the energy consumption is the use of fossil fuels, which is also the major emission source for carbon dioxide. Carbon dioxide is in turn one of the most significant greenhouse gases and will enhance te

ALK positively regulates MYCN activity through repression of HBP1 expression

ALK mutations occur in 10% of primary neuroblastomas and represent a major target for precision treatment. In combination with MYCN amplification, ALK mutations infer an ultra-high-risk phenotype resulting in very poor patient prognosis. To open up opportunities for future precision drugging, a deeper understanding of the molecular consequences of constitutive ALK signaling and its relationship to