Epigenetic deregulation through altered DNA methylation is a fundamental feature of tumorigenesis, but tumor data from bulk tissue samples contain different proportions of malignant and non-malignant cells that may confound the interpretation of DNA methylation values. The adjustment of DNA methylation data based on tumor purity has been proposed to render both genome-wide and gene-specific analys

Cardiovascular disease (CVD) is the leading cause of mortality and morbidity worldwide. While sociodemographic, dietary and lifestyle factors have been well documented in relation to CVD, environmental factors have been less studied. However, considering the ongoing biodiversity, climate, and health crises, it is imperative to better understand the interplay between the environment and health. Thi

The Sensory Processing Measure, second edition (SPM-2), is an American assessment guiding person-centered sensory processing interventions, but it lacks Swedish adaptation for occupational therapists. In eight phases, this study translated the SPM-2 into Swedish and assessed its face validity and preliminary psychometric properties, including internal consistency and inter-scale/item correlations.

Bioelectronics holds great potential as therapeutics, but introducing conductive structures within the body poses great challenges. While implanted rigid and substrate-bound electrodes often result in inflammation and scarring in vivo, they outperform the in situ-formed, more biocompatible electrodes by providing superior control over electrode geometry. For example, one of the most researched met

Turkey’s state broadcaster TRT has produced a clip mocking Iran’s Crown Prince Reza Pahlavi and distorting historical facts about his father, the late Shah Mohammad Reza Pahlavi. The Shah’s legacy includes significant economic growth, modernization, and a substantial reduction in poverty in Iran. Given Turkey’s own human rights issues under President Erdoğan, there is a clear irony in TRT’s critic

Western Europe boasts advanced health care systems, robust kidney care guidelines, and a well-established health care workforce. Despite this, significant disparities in kidney replacement therapy incidence, prevalence, and transplant access exist. This paper presents the third International Society of Nephrology Global Kidney Health Atlas's findings on kidney care availability, accessibility, aff

Neutron scattering techniques have been employed to investigate two key areas of condensed matter physics: superconductivity and quantum magnetism. The experimental studies span two distinct areas: two-band superconductors, where we explore the interplay between superconducting anisotropy and vortex structure, and quasi-one-dimensional (quasi-1D) spin chains, where we investigate the magnetic exci

The extraordinary diversity of flowering plants has long captivated biologists andevolutionary ecologists. Plant-insect relationships are recognized as a major driverof this diversity, with pollinators playing a crucial role in angiosperm speciation andtrait diversification. Numerous observational and experimental studies have shownthat pollinators influence the evolution of floral traits—such as

Recent epidemiological studies have suggested a positive association between ultra-processed food consumption and breast cancer risk, although some studies also reported no association. Furthermore, the evidence regarding the associations between intake of food with lower degrees of processing and breast cancer risk is limited. Thus, we investigated the associations between dietary intake by degre

Background & aims: Epidemiological evidence on ultra-processed food (UPF) and cause-specific mortality remains limited and mixed. Molecular mechanisms underlying UPF intake and mortality remain unexplored. This study aimed to evaluate the associations between UPF consumption, metabolic signatures, and all-cause, premature, and cause-specific mortality. Methods: This study included 27670 partic

This paper presents the results of the 2022 Groundwater Time Series Modelling Challenge, where 15 teams from different institutes applied various data-driven models to simulate hydraulic-head time series at four monitoring wells. Three of the wells were located in Europe and one was located in the USA in different hydrogeological settings in temperate, continental, or subarctic climates. Participa

Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder characterized by brain aggregation of β-amyloid (Aβ) peptides and phosphorylated tau (P-tau) proteins. Extracellular vesicles (EVs) can be isolated and studied for potential roles in disease. While several studies have tested plasma-derived EVs in AD, few have analyzed EVs from cerebrospinal fluid (CSF), which are potentially mo

Identification of preferential flow-paths, such as fractures, is required for various issues in geosciences. When chemicals are injected into the subsurface, monitoring the resulting structural and chemical changes remains a challenge. The ability of geophysical tomography to tackle this problem is not fully explored due to the lack of numerical methods suitable for modeling narrow structures. We

Relationer med nära vuxna är viktiga för barns utveckling. Forskning om känslomässig trygghet, så kallad ”anknytning”, mellan barn och förälder har visat att hur föräldrar bemöter barnets behov av tröst och närhet inverkar på barnets sätt att hantera känslomässig stress och navigera sociala relationer. Även andra omsorgspersoner i ett barns vardagsliv kan bli anknytningsfigurer för barnet, såsom pCurrent child developmental research encourages a more systemic understanding of attachment-related relationship-building. As many young children spend a substantial part of their daily life in professional childcare, e.g., “preschool”, interactions with teachers at preschool are of particular interest in this respect. In bridging the developmentally important contexts of home and preschool for th

Background Implementation of evidence-based practice (EBP) in child and adolescent mental health services (CAMHS) is a priority to improve service delivery and outcomes. Clinicians’ EBP attitudes are likely to play a crucial role in implementation but are poorly understood. This study aimed to assess variation in EBP attitudes in a large national sample of CAMHS clinicians in Sweden, and to compar

Vi som bor och jobbar i byggnader har en stor inverkan på hur mycket energi som de förbrukar. Genom att tydligt förmedla engagerande information till oss kan vi påverkas och göra energimedvetna val i våra hem genom förändringar i ventilationssystem. Att spara energi blir allt viktigare i vårt samhälle. Byggnader och fastigheter står för en betydande del av energiförbrukningen i Sverige, så det är Energy efficiency is becoming a more important part of our energy system. There is a need to investigate energy efficiency measures in the building and real estate sector, which accounts for a significant portion of the total energy consumption in Sweden. Therefore, this study investigates the energy-saving opportunities available to improve energy efficiency in this sector, with a focus on ventil

Bakgrund: Akne är en vanlig hudåkomma, som drabbar många tonåringar. Tonåren innebär en sårbar period i livet, med stora förändringar både psykiskt och fysiskt. Tidigare forskning visar att hudproblem kan få konsekvenser gällande självkänsla och psykiskt mående. Distriktssköterskan kan vara den första som möter tonåringar med akne och har därmed en viktig roll i att förmedla kunskap kring ämnet oc