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World Health Organization (WHO) guideline on the complementary feeding of infants and young children aged 6−23 months 2023: A multisociety response

The recent World Health Organization (WHO) guideline aims to provide evidence-based recommendations on complementary feeding (CF) of healthy term infants and young children 6−23 months living in low-, middle-, and high-income countries, including both breastfed and non-breastfed children. Like WHO, our organizations aim to promote optimal infant and young child nutrition and health, with a focus o

Evaluation of δ-Phase ZrH1.4 to ZrH1.7 Thermal Neutron Scattering Laws Using Ab Initio Molecular Dynamics Simulations

Zirconium hydride is commonly used for next-generation reactor designs due to its excellent hydrogen retention capacity at temperatures below 1000 K. These types of reactors operate at thermal neutron energies and require accurate representation of thermal scattering laws (TSLs) to optimize moderator performance and evaluate the safety indicators for reactor design. In this work, we present an ato

Interobserver agreement on line-field confocal optical coherence tomography image markers in keratinocyte carcinomas and precursor lesions

Line-field confocal optical coherence tomography (LC-OCT) is a new technology for skin cancer diagnostics. However, the interobserver agreement (IOA) of known image markers of keratinocyte carcinomas (KC), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), as well as precursors, SCC in situ (CIS) and actinic keratosis (AK), remains unexplored. This study determined IOA on the

Melanoma Incidence and Mortality Trends in Sweden

IMPORTANCE: Over the past decades, many global regions have experienced a steady increase in the incidence of cutaneous melanoma. However, more recently, a downward trend has been observed in the younger age groups in Australia and the US. Yet, in Europe, none of the countries have reported any significant decline in melanoma incidence for any age group.OBJECTIVE: To assess melanoma incidence and

Understanding the genetic complexity of puberty timing across the allele frequency spectrum

Pubertal timing varies considerably and is associated with later health outcomes. We performed multi-ancestry genetic analyses on ~800,000 women, identifying 1,080 signals for age at menarche. Collectively, these explained 11% of trait variance in an independent sample. Women at the top and bottom 1% of polygenic risk exhibited ~11 and ~14-fold higher risks of delayed and precocious puberty, respe

Outcomes of Cytoreductive Radical Prostatectomy for Oligometastatic Prostate Cancer on Prostate-specific Membrane Antigen Positron Emission Tomography : Results of a Multicenter European Study

BACKGROUND: De novo oligometastatic prostate cancer (omPCa) on prostate-specific membrane antigen (PSMA) positron emission tomography (PET) is a new disease entity and its optimal management remains unknown. OBJECTIVE: To analyze the outcomes of patients treated with cytoreductive radical prostatectomy (cRP) for omPCa on PSMA-PET. DESIGN, SETTING, AND PARTICIPANTS: Overall, 116 patients treated wi

Interplay between glypican-1, amyloid-β and tau phosphorylation in human neural stem cells

Introduction: Alzheimer's disease (AD) is characterized by accumulation of amyloid beta (Aβ) and hyperphosphorylated tau (Tau-P) in the brain. Aβ enhances the activity of kinases involved in the formation of Tau-P. Phosphorylation at Thr 181 determines the propagation of multiple tau phosphorylations. Aβ is derived from the amyloid precursor protein (APP). Cleavage of APP by β-secretase also initi

A comparative assessment of five precipitation products in the Saharan desert of Morocco : Sakia El Hamra basin case study

This study evaluates the performance of five satellite precipitation products (GPM IMERG, TRMM 3B42, ERA5, PERSIANN, and CHIRPS) compared to monthly observations from two weather stations (Laayoune and Essmara) over 2001–2017 using statistical metrics including correlation coefficient (CC) and mean square error (MSE). The results reveal notable differences between products. On a monthly timescale,

From ice-dammed lake to aeolian dunes in the Store Mosse area, SW Sweden

Wind is a significant geomorphological agent in formerly glaciated areas and aeolian deposits surround and stretch across the Store Mosse (Great Bog) bog complex in southwestern Sweden. Both peat and aeolian sand are underlain by lacustrine sediment and the deposits record the area's transition from an initially ice-dammed lake to Ancient Lake Bolmen, which gradually drained, exposing sediments to

Hydrometeorological drought analysis through Two-variate Standardized Index for the Paraná River Basin, Brazil

Brazil has faced severe droughts in recent decades, significantly affecting agriculture, water supply, and hydropower generation, among other sectors. The Paraná River Basin, a major hub for hydropower, has been particularly affected, posing challenges for water management. To address this, we conducted a study to provide tailored climate information for the Brazilian hydroelectric sector. Given t

Total mesorectal excision quality in rectal cancer surgery affects local recurrence rate but not distant recurrence and survival : population-based cohort study

Background: The quality of the total mesorectal excision specimen in rectal cancer surgery is assessed with a three-tier grade (mesorectal, intramesorectal and muscularis propria). This study aimed to analyse the prognostic impact of the total mesorectal excision grade on survival, and to identify risk factors for intramesorectal and muscularis propria resection in a population-based setting. Meth

Trauman med suddiga konturer : Att uppmärksamma och bemöta psykisk sårbarhet bland yngre familjehemsplacerade barn

Boken tar upp de allra yngsta familjehemsplacerade barnen – och deras psykiska mående och utveckling. Den utgår från djupintervjuer med familjehem och företrädare för familjehemsvården i flera svenska kommuner. Men den innehåller även en lättillgänglig översikt av senare års kunskapsutveckling om psykisk sårbarhet bland små placerade barn, och vad som enligt forskning är avgörande för att traumati

Meta-analytical evidence for frequency-dependent selection across the tree of life

Explaining the maintenance of genetic variation in fitness-related traits within populations is a fundamental challenge in ecology and evolutionary biology. Frequency-dependent selection (FDS) is one mechanism that can maintain such variation, especially when selection favours rare variants (negative FDS). However, our general knowledge about the occurrence of FDS, its strength and direction remai

Why here? Factors influencing Palestinian refugees from Syria in choosing Germany or Sweden as asylum destinations

This paper presents the findings of 33 interviews, carried out in 2017, examining the factors influencing Palestinian refugees from Syria (PRS) in choosing Germany or Sweden as asylum destinations. The findings showed that there was a very high degree of destination specificity towards Sweden for nearly all of the participants. This was based on their desire to reach Sweden due to its accessible c

CD163+ macrophages in mantle cell lymphoma induce activation of prosurvival pathways and immune suppression

Mantle cell lymphoma (MCL) is dependent on a supportive tumor immune microenvironment (TIME) in which infiltration of CD163+ macrophages has a negative prognostic impact. This study explores how abundance and spatial localization of CD163+ cells are associated with the biology of MCL, using spatial multiomic investigations of tumor and infiltrating CD163+ and CD3+ cells. A total of 63 proteins wer

Sweden’s Temporary Asylum Law and the Indefinite Statelessness of Refugees

This paper explores the law and policy related to the identification, assessment, and recording of the statelessness of refugees in the Swedish asylum procedure. It considers the gaps in law and policy that can lead to a stateless refugee remaining in a prolonged, or potentially, indefinite stateless situation and the impacts of the temporary asylum law introduced in 2016. The temporary law can be

11th Quebec City Biennale: The Strength of Sleep – The Cohabitations of All the Living : Curated by Marie Muracciole. February 23 to April 28, 2024

Group exhibition. Theme :The Strength of SleepCohabitations of the LivingThe Quebec City Biennial will draw its inspiration from the Canadian winter and the sleeping earth to focus on human sleep and the multiple nuances of the process of waking. Both sleep and the cold season are times of latency, transition, and pause, of suspended productivity, and of resistance against the exploitation of bodi