A method for form finding with dynamic relaxation and Non-Uniform Rational B-Splines (NURBS) based isogeometric membrane elements has been implemented and studied regarding the influence of the discretization and element shape on the form finding. The procedure allows for rapid form finding since NURBS describe the curved geometry well and it is shown that the form-finding can be performed using a

I use Google News to study the relation between news volumes and stock market volatilities. More than nine million stock market-related news stories in English and Chinese are collected and the dynamics of the news volume and the stock market volatility is compared. I find that the stock market volatility and the number of publicly available global news stories are strongly linked in both language

Conceptual design is the first phase in the design process in which all the requirements and design objectives are synthesized into conceptual alternatives. In practice today, major decisions regarding the buildings geometry, massing, and overall form are usually made during the first phase. Considering structural performance requirements during conceptual design enhances interdisciplinary interac

Following on the reiterated claim that accounting inscriptions make action at a distance possible, we draw on post-mathematical topology to explain that this distance work is dependent on inscriptions acting on distances. By adopting a relational understanding of space, we show that accounting inscriptions by themselves create the distances across which they operate. Our case study uses pay-as-you

The development of oncolytic viruses has recently made great progress towards being available to cancer patients. With the breakthrough into clinics, it is crucial to analyze the existing clinical experience and use it as a basis for treatment improvements. Here we report clinical data from 290 patients treated with oncolytic adenovirus. Using clinical variables and treatment characteristics, we c

Dyslipidemia is a chronic deviation from normal blood lipid levels that can lead to atherosclerosis and other cardiovascular diseases; dyslipidemia and its sequelae are caused by the complex interplay of genetic and environmental factors. Although circulating concentrations of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein chole

Antenna current optimization is a tool that offers many possibilities in antenna technology. Optimal currents are determined in the antenna design region and used for physical understanding, as a priori estimates of the possibilities todesign antennas, physical bounds and as figures of merits for antenna designs. Antenna current optimization is particularly useful for small antennas and antennas t

BACKGROUND: Several major analyses have identified a consistent set of independent risk factors for cutaneous malignant melanoma (CMM). A few prognostic models have been presented but some are based on a limited number of patients and others are based on selected groups of patients referred to major institutions. No nationwide population-based prognostic instrument for survival of CMM has been pre

In this proceeding, architecting novel magnetic Cross-Linked-Enzyme-Aggregates (CLEA)nanoparticles to effectively and controllably modify textile surfaces without damaging the fabric itself, will bediscussed. The efficiency is due to exponentially increased surface concentration of biocatalyst and to thechoice of aggregate size which controls the penetration depth and hence preventing the fabric d

BACKGROUND: Obesity is positively associated with colorectal cancer. Recently, body size subtypes categorised by the prevalence of hyperinsulinaemia have been defined, and metabolically healthy overweight/obese individuals (without hyperinsulinaemia) have been suggested to be at lower risk of cardiovascular disease than their metabolically unhealthy (hyperinsulinaemic) overweight/obese counterpart

Rheumatoid arthritis (RA) is a chronic inflammatory condition, which is associated with an increased risk of comorbidity from other diseases. RA disease severity is a major predictor of development of cardiovascular disease, serious infections and malignant lymphoma. This reflects the role of chronic inflammation in the underlying pathology. Recent surveys indicate that although clinical outcomes

PURPOSE: To describe a concept for prevention of secondary conditions in individuals with chronic neuromuscular disabilities by using two Swedish developed follow-up-programmes for cerebral palsy (CP; CPUP) and myelomeningocele (MMC; MMCUP) respectively as examples.METHOD: This paper describes and outlines the rationale, development and implementation of CPUP and MMCUP.RESULTS: Both programmes are

The limited thermal stability of polyhydroxyalkanoates (PHAs) hinders their wide applicability, and methods to improve the processability of these biopolyesters are needed for efficient processing, e.g. by melt extrusion. In the present study we have shown by isothermal gravimetry, dynamic rheology and molecular weight analysis that the thermal stability of the PHAs at the processing temperature c

Background The outcome of axillary ultrasound (AUS) with fine-needle aspiration biopsy (FNAB) in the diagnostic work-up of primary breast cancer has an impact on therapy decisions. We hypothesize that the accuracy of AUS is modified by nodal metastatic burden and clinico-pathological characteristics. Material and methods The performance of AUS and AUS-guided FNAB for predicting nodal metastases wa

OBJECTIVES: To evaluate the safety of intra-articular sprifermin (primary), and to evaluate systemic exposure, biomarkers, histology, and other cartilage parameters in patients with advanced osteoarthritis (OA).METHODS: This was a first-in-human, double-blind, randomised, placebo-controlled trial of single and multiple ascending doses of sprifermin from 3-300 μg in knee OA patients scheduled for t

The system dynamics technique has been demonstrated to be a proper method by which to model and simulate the development of spatial data infrastructures (SDI). An SDI is a collaborative effort to manage and share spatial data at different political and administrative levels. It is comprised of various dynamically interacting quantitative and qualitative (linguistic) variables. To incorporate lingu

BACKGROUND: Anti-Müllerian Hormone (AMH) has been suggested as a marker for ovarian function. Cadmium and lead have been suggested to reduce female fecundity. In this study we aimed to investigate whether environmental exposure to cadmium and lead was associated with alterations in serum-AMH.MATERIALS AND METHOD: The associations between serum-AMH and whole blood cadmium or lead were investigated