New brass alloys containing less or even no lead are being developed, decreasing the environmental impact of the material. One example of an alternative brass is CuZn21Si3P, which contains less than 0.09 wt-% Pb. The research presented in this article evaluates the machinability of CuZn21Si3P as compared to more common, lead-containing free-machining brasses. The results show a marked decrease in

Bokrecension: Wedge, Marilyn (2015). A Disease Called Childhood. Why ADHD Became an American Epidemic. New York: Avery. (250 s.)

This paper investigates the potential of an infant intervention to improve life expectancy, contributing to emerging interest in the early life origins of chronic disease. We track individuals from birth to death, and are able to identify age and cause of death. The intervention was pioneered in Sweden in 1931–1933, and appears to have been pivotal in the emergence of universal infant care program

A 2.8-to-5.8 GHz harmonic VCO designed in a 28 nm UTBB FD-SOI CMOS process adopts a reconfigurable active core to save power at the lower oscillation frequencies, and to enable a trade-off between power consumption and phase noise at all frequencies. Interference caused by the magnetic coupling to and from the VCO inductor is greatly attenuated by resorting to an inductor in the shape of an 8. Sim

A 2.8-to-5.8GHz VCO designed in a 28nm UTBB FD-SOI CMOS process adopts a reconfigurable active core to save power at the lower oscillation frequencies, and to enable a trade-off between power consumption and phase noise at all frequencies. The UTBB FD-SOI CMOS process is instrumental to achieve a tuning range in excess of one octave at low power consumption, while the use of an 8-shaped tank coil

A digital phase-locked loop (DPLL) which uses a high resolution 2-dimension gated-Vernier time-to-digital converter (TDC) is presented. The shaped Vernier quantization of TDC greatly improves the in-band phase noise. Also the 2-dimension structure makes DPLL be able to process large phase errors almost without the influence of latency time. Combined with a high figure-of-merit (FOM) class-D digita

Detection of the androgen receptor splice variant 7 in circulating tumor cells and in prostate cancer tissue harbors prognostic and predictive information. The true value of measuring androgen receptor splice variant 7 to predict response to different treatments is still unproven but is currently under evaluation in clinical trials.

Background: Current prostate cancer screening guidelines conflict with respect to the age at which to initiate screening. Objective: To evaluate the effect of prostate-specific antigen (PSA) screening versus zero screening, starting at age 50-54 yr, on prostate cancer mortality. Design, setting, and participants: This is a population-based cohort study comparing 3479 men aged 50 yr through 54 yr r

Many existing protocols for neuronal differentiation of human pluripotent cells result in heterogeneous cell populations and unsynchronized differentiation, necessitating the development of methods for labeling specific cell populations. Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression pattern

Background: Alzheimer's disease (AD) neuropathology is associated with neuroinflammation, but there are few useful biomarkers. Mutant variants of triggering receptor expressed on myeloid cells 2 (TREM2) have recently been linked to late-onset AD and other neurodegenerative disorders. TREM2, a microglial receptor, is involved in innate immunity. A cleaved fragment, soluble TREM2 (sTREM2), is presen

This paper investigates the association between perinatal health and all-cause mortality for specific age intervals, assessing the contribution of maternal socioeconomic characteristics and the presence of maternal-level confounding. Our study is based on a cohort of 12,564 singletons born between 1915 and 1929 at the Uppsala University Hospital. We fitted Cox regression models to estimate age-var

Background: Depression is linked with alexithymia, anxiety, high HbA1c concentrations, disturbances of cortisol secretion, increased prevalence of diabetes complications and all-cause mortality. The psycho-educational method 'affect school with script analysis' and the mind-body therapy 'basic body awareness treatment' will be trialled in patients with diabetes, high HbA1c concentrations and psych

Results from the present event-related potentials (ERP) study show that tones on Swedish word stems can rapidly pre-activate upcoming suffixes, even when the word stem does not carry any lexical meaning. Results also show that listeners are able to rapidly restore suffixes which are replaced with a cough. Accuracy in restoring suffixes correlated positively with the amplitude of an anterior negati

This study aims to gain a greater insight into cycling as an element of mobility among those in later life. The characteristics and views of those who cycle, those who have never cycled, as well as those who have discontinued cycling in later life are the main focus. Malmö, a city in the south of Sweden with a strong emphasis on bicycle planning, is the study area. This study employed a mixed meth