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Lifestyle precision medicine: the next generation in type 2 diabetes prevention?

The driving force behind the current global type 2 diabetes epidemic is insulin resistance in overweight and obese individuals. Dietary factors, physical inactivity, and sedentary behaviors are the major modifiable risk factors for obesity. Nevertheless, many overweight/obese people do not develop diabetes and lifestyle interventions focused on weight loss and diabetes prevention are often ineffec

Pre- and post-migration labour market mismatch in Sweden 1970-1990

Labour market outcomes for immigrants in general is a well researched field, but the mechanisms behind labour market mismatches among immigrants post-migration is still in need of empirical research. Using a unique and newly compiled dataset on Swedish immigrants, also containing pre-migration occupational and educational information data, this study aims makes use of maximum likelihood models to

Clean water technologies and urban mortality in Sweden 1885-1925

Using a newly digitised historical dataset on clean water technologies in Swedish cities, this study tries to find the causal effect (and the magnitude of this effect) of the introduction of clean water technology on mortality in urban areas. Using urban mortality data on a county level, and clean water access data on city level, both OLS, fixed effects, and difference-in-differences models are tr

Survival of rat pancreatic islets is partly controlled by a TCF7L2-p53-p53INP1 dependent pathway

Background and aims: TCF7L2 is both an activator and an inhibitor of transcription and the most highly associated type 2 diabetes gene known to date. It influences beta cell survival and function, i.e. incretin hormonal effects, insulin processing and secretion. However, its target genes in pancreatic islets are not fully described and the molecular mechanism whereby it propagates its effects on i

Simultaneous Visualization of Hydrogen Peroxide and Water Concentrations Using Photofragmentation Laser-Induced Fluorescence

A concept based on photofragmentation laser-induced fluorescence (PFLIF) is for the first time demonstrated for simultaneous detection of hydrogen peroxide (H2O2) and water (H2O) vapor in various mixtures containing the two constituents in a bath of argon gas. A photolysis laser pulse at 248 nm dissociates H2O2 into OH fragments, whereupon a probe pulse, delayed 100 ns and tuned to an absorption l

Orphanhood and mistreatment drive children to leave home – A study from early AIDS-affected Kagera region, Tanzania

The aim of this mixed-method study was to explore the trajectories of leaving home, and views and experiences among children and youth in the Kagera region in Tanzania, who have lived on the streets or been domestic workers. The main results showed that orphanhood and mistreatment were the main reasons for leaving home: few children lived with their parents before they left, and leaving home was a