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Automated quantification of neuronal swellings in a preclinical rodent model of Parkinson's disease detects region-specific changes in pathology

Background: The development of axonal pathology is a key characteristic of many neurodegenerative disease such as Parkinson's disease and Alzheimer's disease. With advanced disease progression, affected axons do display several signs of pathology such as swelling and fragmentation. In the AAV vector-mediated alpha-synuclein overexpression model of Parkinson's disease, large (> 20 µm2) pathological

Serum S100A8/A9 concentrations are associated with neuropsychiatric involvement in systemic lupus erythematosus: a cross-sectional study

BACKGROUND: Neuropsychiatric (NP) involvement and fatigue are major problems in systemic lupus erythematosus (SLE). S100A8/A9 is a marker of inflammation and responds to therapy in SLE patients. S100A8/A9 has an immunopathogenic role in various neurological diseases. We investigated S100A8/A9 in relation to NP-involvement and fatigue in SLE.METHODS: 72 consecutive SLE outpatients at a tertiary cen

Through light and darkness: A literature review of children's independent mobility after dark

Background and objectivesDarkness is a significant barrier to children’s independent mobility (Shaw et al., 2015) affecting the perception and use of outdoor environments, making them less attractive, and increasing social fears (Cele, 2019). This literature review addresses the question of how artificial outdoor lighting may serve to provide children independent mobility after dark.Process and meBackground and objectivesDarkness is a significant barrier to children’s independent mobility (Shaw et al., 2015) affecting the perception and use of outdoor environments, making them less attractive, and increasing social fears (Cele, 2019). This literature review addresses the question of how artificial outdoor lighting may serve to provide children independent mobilityafter dark.Process and met

Social challenges within sustainable entrepreneurial ecosystems

The formation of sustainable entrepreneurial ecosystems to foster sustainable entrepreneurship in regional and national levels has become an increasing phenomenon. Therefore, the research stream of sustainable entrepreneurial ecosystems is gaining relevance in the sustainable entrepreneurship literature. What has been missing, however, is an empirical analysis of stakeholder collaborations in sust

Research Handbook On Human Rights And Poverty : Research Handbooks in Human Rights

This important Research Handbook explores the nexus between human rights, poverty and inequality as a critical lens for understanding and addressing key challenges of the coming decades, including the objectives set out in the Sustainable Development Goals. The Research Handbook starts from the premise that poverty is not solely an issue of minimum income and explores the profound ways that depriv