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Background: Several cancer types have increased PFKFB3, a glycolytic enzyme for which potent inhibitors have been found. Inhibition of PFKFB3 impairs DNA repair after irradiation of cancer cells, making it a possible radiosensitization target. The SweBCG91RT trial, in which breast cancer patients were randomized to postoperative radiotherapy or not, was used to investigate PFKFB3 as a clinical mar

Monitoring agricultural land with optical remote sensing offers a valuable tool for estimating crop yield and supporting decision-making for food security. Cropland phenology indicators, such as the start of season (SOS), the end of season (EOS), and the number of growing seasons per year, provide essential information for land managers. While established toolboxes like TIMESAT have been extractin

The functionalization of cubosomes for their use in drug delivery, bioimaging, and biosensing can be achieved by incorporating molecules that are sensitive to physiological conditions, such as phospholipids. Considering this, it is relevant to investigate the interaction between phospholipid-containing cubosomes and phospholipase A2 (PLA2), a ubiquitous enzyme associated with inflammatory diseases

Photoacoustic imaging can potentially map oxygen saturation (sO2) non-invasively. However, in-vivo human application is challenging due to spectral coloring, which causes a wavelength-dependent fluence attenuation and uncertainty in the estimation of chromophore concentrations deep in tissue. This study compares the performances of two previously proposed methods for spectral coloring compensation

Surface-enhanced Raman scattering (SERS) technology can detect molecular information; Because of its high sensitivity, it is widely used in chemical analysis. In this study discussed the experimental detection of 1,4-diethynylbenzene molecule based on SERS technology. The SERS spectra of 1,4-diethynylbenzene molecule were calculated by Density Functional Theory (DFT) simulation, and the results sh

Due to the large extent of seawater surface over the globe, aerosol particles spend significant time being transported over this type of surface. Therefore, global aerosol circulation is largely impacted by the processes particles undergo during long-range transport overseas. In this study, we investigated submicron aerosol (PM1) chemical composition changes during long-range transport events over

Background: The aim was to develop a theoretical framework for how errors in estimated activities propagate to a dispersion in time-integrated activity in radionuclide-therapy dosimetry and how this affects the comparison of radionuclide-therapy dosimetry schemes. Methods: Formulae for the variance of relative errors of estimated time-integrated activities and relative differences in time-integrat

En kort, Wittgensteininfluerad betraktelse i åminnelse av Karl Dahlstrand.

The effect of β-glucan was tested on microstructure, sensory-specific satiation, subsequent food intake, and in vitro lipid digestion. A high internal phase emulsion was prepared with 75 % milk fat and 25 % whey protein water dispersion, and added as the lipid source to milkshake matrices. Two milkshake variants, one with 1 % β-glucan and the other without fibre, were produced and characterised by

Over the past 50 years there has been an unprecedented increase in pollution globally. Population growth and higher standards of living have resulted in increases in global consumption facilitated by industrialisation and globalisation of goods and services thus resulting in the release of environmental pollutants on a mass scale. This article analyses the effects and consequences of pollution on

Background: Rare variants of the triggering receptor expressed on myeloid cell 2 (TREM2) gene are strong risk factors for Alzheimer’s disease (AD), and drugs targeting the TREM2 protein are being developed. However, it is unknown what the effect of TREM2 variants is on the AD phenotype. Methods: Here we studied a full range of clinical and biomarker measures in a large cohort of TREM2 variant carr

Patients with systemic lupus erythematosus (SLE) face an approximately 30 % risk of thrombosis post-diagnosis. However, there remains significant knowledge gaps regarding causative mechanisms, and there is a lack of specific antithrombotic guidelines. This systematic review aims to examine the existing literature regarding the mechanisms contributing to thrombosis risk in SLE, focusing on five pre

Intrauterine fetal programming determines cardiorenal interaction later in life. We hypothesize that early life factors affect adult glomerular filtration rate and mean arterial pressure (MAP) directly or by interacting with postnatal growth trajectories. The population-based LifeGene study (Sweden) randomly recruited individuals aged 18 to 43 years (n = 12 167). They filled in a web-questionnaire

Catalytic studies traditionally rely on steady-state conditions resulting in time-averaged datasets that do not differentiate between active and spectator species. This limitation can cause misinterpretations of catalytic function, as the signal of short-lived intermediates responsible for producing desired reaction products is often masked by more intense spectator species. Time-resolved ambient

The genetic contributions to early onset heart failure (HF) are incompletely understood. Genetic testing in advanced HF patients undergoing heart transplantation (HTx) may yield clinical benefits, but data is limited. We performed deep-coverage whole genome sequencing (WGS) in 102 Swedish HTx recipients. Gene lists were compiled through a systematic literature review. Variants were prioritized for

The paper deals with the effects that robot adoption in a country may generate in other trade-related countries. We concentrate on the Top 5 European economies as robot adopters over the period from 1995 to 2018 (Italy, Germany, France, Spain, UK) by testing whether robot adoption affects employment dynamics also beyond borders. To reach this goal we develop a composite indicator that captures bot

Induced pluripotent stem cells (iPSCs) have significant potential for disease modeling and cell therapies. However, their wide-spread application has faced challenges, including batch-to-batch variabilities, and notable distinctions when compared to embryonic stem cells (ESCs). Some of these disparities can stem from using undefined culture conditions and the reprogramming procedure, however, the