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Pathogens cause disease and play an important role in shaping evolution of the host immune system. They create pressure on host immunity to evolve in numerous ways, most commonly by increasing divergence between species (positive selection) or increasing polymorphisms within a population (balancing selection). Especially with balancing selection, trade-offs between different traits, for example re

In this paper, we present two thermalized setups for in situ operando X-ray diffraction data collection in temperature ranging from 0° to 100 °C: a modified Leriche cell and a coin cell chamber. Both setups proved proper thermalization and representative electrochemistry. While the coin cell chamber may only be used in transmission mode, the modified Leriche cell can also be used in reflection mod

Background: Sweets, chocolate, and sweet bakery products are generally high in energy and added sugar, whereas the levels of essential nutrients and fibre are low. According to sales statistics, the consumption of sweets and chocolate is high in the Nordic and Baltic countries. Objective: This scoping review describes the totality of evidence for the role of sweets and other sugary foods for healt

Le Covid-19 a déclenché une vague de confinements à travers le monde, contribuant à un grave ralentissement de l’activité économique. Les gouvernements ont réagi en adoptant des mesures budgétaires et monétaires expansionnistes. Nous comparons les résultats sanitaires et économiques de la Suède, généralement considérée comme une exception qui repose davantage sur des recommandations et des ajustem

Background: Etranacogene dezaparvovec, the first gene therapy approved for haemophilia B treatment, was shown to be superior to treatment with continuous prophylactic factor IX in terms of bleeding protection 18 months after gene therapy in a phase 3 trial. We report post-hoc 24-month efficacy and safety data from this trial to evaluate the longer-term effects of etranacogene dezaparvovec in indiv

Poor management and excessive pumping of groundwater (GW) resources can lead to a significant decline in GW level, which may result in land deformation and compaction of compressible fine-grained soils within or adjacent to the aquifer. Soil compaction and resulting land deformation may be permanent if the GW level declines beyond the maximum historical stress. In extreme cases, the aquifer may lo

Background/Aim: Type 1 diabetes is an autoimmune disease that involves the development of autoantibodies against pancreatic islet beta-cell antigens, preceding clinical diagnosis by a period of preclinical disease activity. As screening activity to identify autoantibody-positive individuals increases, a rise in presymptomatic type 1 diabetes individuals seeking medical attention is expected. Curre

Enligt forskare och praktiker innebär klimatförändringarna särskilda utmaningar för freden. För att förstå vilka dessa utmaningar är och hur man ska hantera dem måste man ta hänsyn till kön, eftersom både erfarenheter av och processer för fred, samt drivkrafter bakom klimatförändringar är könsbundna. Exempelvis kan kvinnor och män uppleva förhållandena efter en vapenvila på olika sätt, eller så kaScholars and practitioners argue that climate change poses particular challenges for peace. In order to understand what these challenges are and how to tackle them necessitates attention to gender, since experiences and processes of peace are gendered, as are experiences and drivers of climate change. For instance, women and men may experience conditions after a ceasefire differently, or climate h

With rising rates of antimicrobial resistance throughout the world, it is time to revisit antibiotic prescribing policies and practices, and dentistry is an important area for focused intervention, as it accounts for up to 15% of all antimicrobial prescriptions. In this narrative review, we have analyzed the current state of the knowledge, attitudes, and practice regarding antimicrobial use among

Colon cancer is among the most lethal and prevalent malignant tumors in the world, and the lack of effective therapies highlights the need for novel therapeutic approaches. Schisandrin B (Sch B), a lignan extracted from the fruit ofSchisandra chinensis, has been reported for its anticancer properties. However, to date, no studies have been done to characterize the exact molecular mechanisms underl

Background: Increasing trends of oxidized linalool contact allergy have been reported. However, the impact of reactivity and dose in eliciting allergic contact dermatitis caused by linalool hydroperoxides is insufficiently investigated. Objectives: To perform repeated open application tests (ROATs) using the real-world concentrations of linalool hydroperoxides in patients and control participants.

A radical transformation of the transport industry is required in order to achieve a fossil-fuel-free vehicle fleet and reach the greenhouse gas emissions goals. Electrification plays a crucial role in this radical process. An electric road system (ERS) is a road that supplies power to electric vehicles as they drive on it, offering numerous advantages. These include an extended driving range, dec

Myocardial infarction is a leading cause of death globally but is notoriously difficult to predict. We aimed to identify biomarkers of an imminent first myocardial infarction and design relevant prediction models. Here, we constructed a new case–cohort consortium of 2,018 persons without prior cardiovascular disease from six European cohorts, among whom 420 developed a first myocardial infarction

This paper presents an experimental study where the mechanical behaviour of single-dowel timber connections made of acetylated Scots pine is compared with the behaviour of connections made from untreated Scots pine. The main aim was to evaluate the influence of the acetylation on the connection brittleness and also to compare the experimental results to the design provisions of the current Europea

The aim of this study was to add knowledge of the longitudinal associations between gaming and emotional closeness between parents and their children. We hypothesized that parent–child emotional closeness was linked to less gaming activity over time and that more gaming activity was linked to less parent–child emotional closeness over time. We also tested the moderating effect of child gender on t