Background: The emergence of highly active novel agents has led some to question the role of autologous haematopoietic stem-cell transplantation (HSCT) and subsequent consolidation therapy in newly diagnosed multiple myeloma. We therefore compared autologous HSCT with bortezomib–melphalan–prednisone (VMP) as intensification therapy, and bortezomib–lenalidomide–dexamethasone (VRD) consolidation the

April 2013Scandinavian Journal of Disability Research 16(sup1):Active social citizenship: the case of disabled peoples' rights to personal assistance LicenseCC BY Karen ChristensenKaren ChristensenIngrid GuldvikIngrid GuldvikMonica LarssonMonica Larsson

With the broader industrial application of Additive Manufacturing (AM), designers are facing new challenges in conceptual design for AM. To better understand the problematic, the authors organised a design workshop with six experts in AM. The paper presents the results of the conducted design workshop and discusses the current and future trends in research on the conceptual design for AM.

Strain localisation structures, such as shear fractures and compaction bands, are of importance due to their influence on permeability and therefore outgassing, a factor thought to influence eruptive style. In this study, we aim to develop a better understanding of strain localisation in porous volcanic rocks using X-ray tomographic images of samples of porous andesite (porosity = 0.26) acquired b

In claiming that metadata possess the power to put historical awareness into the act of listening, this article examines digital music use as an aesthetic situation driven by potentialities of becoming. Working from a theoretical foundation amalgamating digital music archives and metadata as environments the article discusses Georgina Born’s notion of musical assemblages alongside the concept of v

Malignant rhabdoid tumour (MRT) is a childhood neoplasm of high malignancy characterised by biallelic mutation and/or loss of the epigenetic master regulator SMARCB1, accompanied by no or few other oncogenic drivers. In spite of their generally low mutational burden, an intratumoural T-cell response has been reported in a subset of MRTs, indicating that immune checkpoint inhibition may be consider

Coxsackievirus A24 variant (CVA24v) is a major causative agent of acute hemorrhagic conjunctivitis outbreaks worldwide, yet the evolutionary and transmission dynamics of the virus remain unclear. To address this, we analyzed and compared the 3C and partial VP1 gene regions of CVA24v isolates obtained from five outbreaks in Cuba between 1986 and 2009 and strains isolated worldwide. Here we show tha

Objectives The aim of this study is to determine diagnostic patterns in the prehospital paediatric population, age distribution, the level of monitoring and the treatment initiated in the prehospital paediatric case. Hypothesis was that advanced prehospital interventions are rare in the paediatric patient population. Setting We performed a retrospective population-based registry cohort study of ch

Inorganic perovskites display an enticing foreground for their wide range of optoelectronic applications. Recently, supercrystals (SCs) of inorganic perovskite nanocrystals (NCs) have been reported to possess highly ordered structure as well as novel collective optical properties, opening new opportunities for efficient films. Here, we report the large-scale assembly control of spherical, cubic, a

Factor I (FI) is one of the main inhibitors of complement activity, and numerous rare coding variants have been reported in patients with age-related macular degeneration, atypical hemolytic uremic syndrome and C3 glomerulopathy. Since many of these variants are of unknown clinical significance, this study aimed to determine the effect of rare coding variants in the complement factor I (CFI) gene

The fouling of the membranes in skim milk ultrafiltration with the nominal molecular weight cut-off (MWCO) of 100 kDa fabricated from different polymers (polysulfone (PSF), polysulfonamide (PSA), aromatic polyamide (PA), polyacrylonitrile (PAN), cellulose acetate (CA) and regenerated cellulose (RC)) was studied. The membrane structure and physical-chemical properties of the selective layer were an

The TIARA (Test Infrastructure and Accelerator Research Area) project funded by the European Union 7th framework programme made a survey of provision of education and training in accelerator science in Europe. This survey highlighted the need for more training opportunities targeting undergraduate-level students. This need is now being addressed by the European Union H2020 project ARIES (Accelerat

“The definition of insanity is doing the same thing over and over again but expecting different results.” This quote by Albert Einstein highlights our need for new formats of communication to address the knowledge-action gap regarding climate change and other sustainability challenges. This includes reflection, and communication spaces, as well as methods and approaches that can catalyze the emerg

Objectives: To investigate the interaction effect of sex and early vs. late onset of Alzheimer’s disease (AD) on long-term cognitive and functional outcomes and survival. Methods: The Swedish Alzheimer Treatment Study (SATS) is a prospective, observational, multicentre study of clinical practice involving 1,017 participants diagnosed with mild-to-moderate AD at the start of cholinesterase inhibito

Using Small-Angle Neutron Scattering (SANS) we have studied the flux line lattices of the first heavy-fermion superconductor to be discovered, CeCu2Si2, the well-known high-temperature superconductor YBa2Cu3O7, along with Ca-doped variants of this compound, and several topological superconductor candidates that have attracted a lot of attention in the last few years, such as PbTaSe2, Au2Pb and β-B