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Adaptive branching in source-sink habitats

Evolution and ecological diversification in a heterogeneous environment is driven by an often complex interplay between local adaptation and dispersal between different habitat types. Heterogeneous environments also easily generate source-sink dynamics of populations coupled by dispersal. It follows that local adaptation and possible adaptive radiation almost by necessity involves adaptation to a

Nanoparticles from Lipid-Based Liquid Crystals: Emulsifier Influence on Morphology and Cytotoxicity.

Here, monoolein-based nanoparticles (NPs), obtained through fragmentation of bulk liquid crystalline phases, and stabilized by two different emulsifiers, namely, Pluronic F127 (PF127) and lauroylcholine chloride (LCh), are investigated for structural features and for short-term in vitro cytotoxicity. Depending on the emulsifiers, different morphologies of the lipid NPs (cubosomes and liposomes) ar

Revisiting reflexive archaeology at Çatalhöyük : integrating digital and 3D technologies at the trowel’s edge

The aim of this paper is to summarize progress in the development of reflexive methods at Çatalhöyük over the past 20 years, and to describe some recent innovations that have used digital and 3D technologies to enhance the original reflexive aims. While digital technologies were not at the forefront of the methods described in an initial account of reflexive methods published in Antiquity (Hodder

Entity extraction: From unstructured text to DBpedia RDF triples

In this paper, we describe an end-to-end system that automatically extracts RDF triples describing entity relations and properties from unstructured text. This system is based on a pipeline of text processing modules that includes a semantic parser and a coreference solver. By using coreference chains, we group entity actions and properties described in different sentences and convert them into en

Intestinal dendritic cell migration and induction of T cell responses

The intestine represents the body’s largest surface exposed to the outer world and is thus a major entry site for pathogens such as bacteria and viruses. The intestinal immune system has the important task of protecting us against infection while maintaining tolerance against the vast amount of commensal microbes populating the intestinal tract and the multitude of foreign antigen present in the d

Lipid synthesis and secretion in HepG2 cells is not affected by ACTH

Apolipoprotein B (apoB) containing lipoproteins, i.e. VLDL, LDL and Lp(a), are consequently lowered by ACTH treatment in humans. This is also seen as reduced plasma apoB by 20-30% and total cholesterol by 30-40%, mostly accounted for by a decrease in LDL-cholesterol. Studies in hepatic cell line (HepG2) cells showed that apoB mRNA expression is reduced in response to ACTH incubation and is followe

Constrainedly fair job assignments under minimum wages

A number of jobs are to be assigned to a greater number of workers. While having to abide by the law of minimum wages, firms must determine who should be assigned which job and at what Salary. In Such situations fair (envy-free) allocations usually fail to exist. To cope with this Situation, this paper proposes a new concept of fairness, called constrained fairness. Among the set of constrainedly

Time-variant analysis and design of a power efficient ISM-band quadrature receiver

In this work a 2.2 GHz quadrature receiver front-end suitable for low-power applications is presented. The low-noise amplifier, the mixer and the voltage-controlled oscillator are merged into a single stage, making the circuit capable of extreme current reuse while keeping it still functional at low supply voltage. A careful linear time-variant analysis is proven to be necessary to accurately pred

Low serum levels of short-chain fatty acids after lactulose ingestion may indicate impaired colonic fermentation in patients with irritable bowel syndrome.

Ingestion of low-digestible carbohydrates triggers symptoms in patients with irritable bowel syndrome (IBS). These carbohydrates become substrates for microbial fermentation in the colon, yielding short-chain fatty acids (SCFAs) that are readily absorbed. Aiming to compare colonic fermentation in patients with IBS and healthy controls, we analyzed the concentrations of SCFA in serum at fasting and

Generation and oxidation of aerosol deposited PdAg nanoparticles

PdAg nanoparticles with a diameter of 10 nm have been generated by an aerosol particle method, and supported on a silica substrate. By using a combination of X-ray Energy Dispersive Spectroscopy and X-ray Photoelectron Spectroscopy it is shown that the size distribution of the particles is narrow and that the two metals form an alloy with a mixture of 75% Pd and 25% Ag. Under oxidizing conditions,

Occupation and risk of lymphoma: a multicentre prospective cohort study (EPIC)

Objectives Evidence suggests that certain occupations and related exposures may increase the risk of malignant lymphoma. Farming, printing and paper industry, wood processing, meat handling and processing, welding, shoe and leather manufacturing and teaching profession are among the categories that have been implicated in previous studies. The relationship between occupation and malignant lymphoma

Reversible electron-hole separation in a hot carrier solar cell

Hot-carrier solar cells are envisioned to utilize energy filtering to extract power from photogenerated electron-hole pairs before they thermalize with the lattice, and thus potentially offer higher power conversion efficiency compared to conventional, single absorber solar cells. The efficiency of hot-carrier solar cells can be expected to strongly depend on the details of the energy filtering pr

Elevated pulmonary arterial pressure and altered expression of Ddah1 and Arg1 in mice lacking cavin-1/PTRF.

Caveolae are invaginations in the plasma membrane that depend on caveolins and cavins for maturation. Here, we investigated the pulmonary phenotype in mice lacking cavin-1. Bright field and electron-microscopy showed that the cavin-1-deficient mice lacked caveolae in the lung, had an increased lung tissue density, and exhibited hypertrophic remodeling of pulmonary arteries. The right ventricle of

Acid-Catalyzed Nucleophilic Aromatic Substitution: Experimental and Theoretical Exploration of a Multistep Mechanism.

The mechanism for the acid-mediated substitution of a phenolic hydroxyl group with a sulfur nucleophile has been investigated by a combination of experimental and theoretical methods. We conclude that the mechanism is distinctively different in nonpolar solvents (i.e., toluene) compared with polar solvents. The cationic mechanism, proposed for the reaction in polar solvents, is not feasible and th

Total Serum Cholesterol and Cancer Incidence in the Metabolic Syndrome and Cancer Project (Me-Can)

Objective: To investigate the association between total serum cholesterol (TSC) and cancer incidence in the Metabolic syndrome and Cancer project (Me-Can). Methods: Me-Can consists of seven cohorts from Norway, Austria, and Sweden including 289,273 male and 288,057 female participants prospectively followed up for cancer incidence (n = 38,978) with a mean follow-up of 11.7 years. Cox regression mo

Eating-related problems among 13-15 year old Swedish adolescents: Frequency and stability over a one-year period.

Abstract in UndeterminedThe frequency of eating-related problems in young adolescents, and their stability over a one-year period, was studied by the RiBED-8 (Risk Behaviours related to Eating Disorders, 8 items) in a community sample of 13-15 year old adolescents who took part in a prospective study with a 2-wave longitudinal design. The RiBED-8 was found to have good reliability and construct va