prevalence was reported as 1:3000-4000 worldwide, making it the main reason for blindness in the working population in industrial countries. The mutations of over 70 genes have been related to this genetic disorder, and there is generally no effective treatment, except for gene therapy for the RPE65 mutations. Hence, new molecular targets are required for novel treatment development. The signaling

Although gamification is a popular term, the concept has rarely been applied to political studies. Therefore, this chapter provides an overview of the key features of gamification and offers an adapted definition of gamification suited to the study of electoral politics. To help illustrate this definition, two examples of gamification from recent campaigns are discussed: the uCampaign mobile appli

Osteosarcoma is a malignant cancer of the bone mainly affecting adolescents. Despite progress, the clinical management of osteosarcoma is still challenging. With the current chemotherapy protocol being used for more than 30 years, the number of poor responders is increasing. Although new treatments have been explored since then, no improved tumor eradication effect have been found. In the present

Three decades ago, systematic research on possible acute and long-term aftereffects of peritraumatic dissociation (PD) was partly spurred by the proposal of a Brief Reactive Dissociative Disorder (BRDD) and the associated literature reviews and analyses of datasets (Cardeña, Lewis-Fernández, Beahr, Pakianathan & Spiegel, 1996; Cardeña et al., 1998; Spiegel & Cardeña, 1991). The goal was to

The experience of one’s identity being substituted by that of some entity from within or without challenges basic Western premises about the self. One of them is that we have a single, discrete identity or self that cannot be replaced by external influences, spiritual or otherwise. A related premise is that our conscious self owns and controls our body and mental life. A myriad of perspectives can

Minna Lerner, Joakim Medin, Christian Jamtheim Gustafsson, Sara Alkner and Lars E. Olsson.

Cardiovascular disease (CVD) is the leading cause of death globally, impacted by both extrinsic and intrinsic factors. The disease at the molecular level, however, is governed by inflammation and characterized by endothelial dysfunction. Over the last decade extracellular vesicles (EVs) have emerged as crucial mediators of intercellular communication especially under varied pathophysiological cond

Streptococcus bovis/Streptococcus equinus complex (SBSEC) is a common cause of infective endocarditis (IE). For IE-pathogens, the capacity to activate and aggregate platelets is believed to be an important virulence mechanism. While the interactions between bacteria and platelets have been described in detail for many Gram-positive pathogens, little research has been carried out with SBSEC in this

Att den fria världen avbryter sina diplomatiska relationer med Irans totalitära regim är avgörande för att begränsa islamiska regimens terror och flyktingsspionage, skriver Arvin Khoshnood och Ardavan Khoshnood, Irankännare.The free world's severance of diplomatic relations with Iran's totalitarian regime is crucial to curbing the Islamic regime's terror and espionage, write Arvin Khoshnood and Ardavan Khoshnood, Iran experts.

Hur påverkas synergonomin av att jobba vid fler och stora skärmar? Det ska Hillevi Hemphälä, doktor i arbetsmiljöteknik, undersöka i en treårig forskningsstudie.– Enligt de gamla rekommendationerna ska datorskärmar på upp till 26 tums storlek placeras på 90 centimeters avstånd för att vi ska undvika huvudrörelser i sid- och höjdled. Men många skrivbord i dag är 80 centimeter och datorskärmarna oft

Affibody molecules constitute a class of small (7 kDa) scaffold proteins that can be engineered to have excellent tumor targeting properties. High reabsorption in kidneys complicates development of affibody molecules for radionuclide therapy. In this study, we evaluated the influence of the composition of cysteine-containing C-terminal peptide-based chelators on the biodistribution and renal reten

Affibody molecules, small (7 kDa) scaffold proteins, are a promising class of probes for radionuclide molecular imaging. Radiolabeling of Affibody molecules with the positron-emitting nuclide 68Ga would permit the use of positron emission tomography (PET), providing better resolution, sensitivity, and quantification accuracy than single-photon emission computed tomography (SPECT). The synthetic an

Platelet-derived growth factor receptor β (PDGFRβ) is a transmembrane tyrosine kinase receptor involved, for example, in angiogenesis. Overexpression and excessive signaling of PDGFRβ has been observed in multiple malignant tumors and fibrotic diseases, making this receptor a pharmaceutical target for monoclonal antibodies and tyrosine kinase inhibitors. Successful targeted therapy requires identi

PURPOSE: Human epidermal growth factor receptor type 3 (HER3) is a transmembrane receptor tyrosine kinase belonging to the HER (ErbB) receptor family. Membranous expression of HER3 is associated with trastuzumab resistance in breast cancer and the transition to androgen independence in prostate cancer. Imaging of HER3 expression in malignant tumors may provide important diagnostic information that

UNLABELLED: Affibody molecules are small (7 kDa) nonimmunoglobulin scaffold proteins with favorable tumor-targeting properties. Studies concerning the influence of chelators on biodistribution of (99m)Tc-labeled Affibody molecules demonstrated that the variant with a C-terminal glycyl-glycyl-glycyl-cysteine peptide-based chelator (designated ZHER2:V2) has the best biodistribution profile in vivo a