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Pushing the limits of standard CMOS

An improved clocking scheme and sharper circuit design and logic selection, which have yielded a five-to-tenfold increased in the speed of standard CMOS ICs, are discussed. The clocking strategy relies on a true single-phase clock, device sizes are varied to optimize their speed, and a precharged logic style reduces capacitive loads. The tradeoff is roughly a doubling of circuit area. The high-spe

Increased Prevalence of Multiple Sclerosis Among COPD Patients and Their First-Degree Relatives: A Population-based Study.

In both chronic obstructive pulmonary disease (COPD) and multiple sclerosis (MS), combinations of environmental and genetic factors are likely to increase the vulnerability to acquire disease. This study was undertaken to investigate any possible comorbidity of COPD and MS, thus indicating common inflammatory vulnerability. Individuals with a diagnosis of COPD (including chronic bronchitis and emp

Gestational diabetes: prospective interview-study of the developing beliefs about health, illness and health care in migrant women.

Aims and objectives. To explore the development over time of beliefs about health, illness and health care in migrant women with gestational diabetes mellitus born in the Middle East and living in Sweden and to study the influence on self-care and care seeking. Background. With today's extensive global migration, contact with the new society/health care confronts the migrant's culture of origin wi

Can pulsed ultrasound increase tissue damage during ischemia? A study of the effects of ultrasound on infarcted and non-infarcted myocardium in anesthetized pigs

BACKGROUND: The same mechanisms by which ultrasound enhances thrombolysis are described in connection with non-beneficial effects of ultrasound. The present safety study was therefore designed to explore effects of beneficial ultrasound characteristics on the infarcted and non-infarcted myocardium. METHODS: In an open chest porcine model (n = 17), myocardial infarction was induced by ligating a co

Embracing price discrimination: TRIPS and the suppression of parallel trade in pharmaceuticals

In December 2005, the WTO responded to the HIV/AIDS pharmaceutical crisis in the least developed world by voting to make the first permanent amendment to the WTO Agreements since their original negotiation during the Uruguay Round. New Article 31bis will amend the TRIPS Agreement to permit compulsory manufacturing licenses in order to facilitate supply of needed pharmaceuticals to those countries

Health Consequences of Catabolic Synthesis of Hippuric Acid in Humans.

Hippuric acid has been a major human metabolite for years. However, there is no well-known documented health benefit associated with it except for excretion of environmental-toxic exposures of aromatic compounds such as toluene, or from dietary protein degradation and re-synthesis by intestinal microflora metabolism of quinic acid via the shikimate pathway. Thus hippuric acid can appear in humans

Clonal repertoire diversification of a neutralizing cytomegalovirus glycoprotein B-specific antibody results in variants with diverse anti-viral properties.

Cytomegalovirus induces a chronic infection that in normal individuals is controlled by the immune system. In the case of humoral immunity, epitopes, in particular antigenic domain-1, in glycoprotein B have proven to be important for the induction of virus-neutralizing activity. Such antibodies can exert potent virus-neutralizing activity but can also block neutralizing antibodies from binding. Fu

Sjukvårdens metoder bör analyseras ur ett etiskt perspektiv.

Many methods exist for ethical analysis guiding decision-making. This essay presents only one method. Both facts and values are employed with this method and, as an example we use a Swedish preventative measure for individuals who abuse narcotics. The ethical analysis presupposes good knowledge of the case at hand and the approach recommended is a combination of stakeholder analysis and decision m

Den ädle terroristen

Om mannen som försökte döda Adolf Hitler 1944, Claus Schenk von Stauffenberg i tysk historieskrivning och amerikansk filmtradition