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Objective: To study transitions from and to chronic widespread pain (CWP) over 7 years in patients with rheumatoid arthritis (RA). Method: Two postal questionnaires were sent to patients included in the BARFOT (Better Anti-Rheumatic Pharmacotherapy) study, the first in 2010 and the second in 2017. The questionnaires assessed pain, number of tender and swollen joints, functional disability, health-

It is not sufficiently known that frequentist statistics cannot provide direct information on the probability that the research hypothesis tested is correct. The error resulting from this misunderstanding is compounded when the hypotheses under scrutiny have precarious scientific bases, which, generally, those of complementary alternative medicine (CAM) are. In such cases, it is mandatory to use i

Survivors of malignant bone tumors in childhood are at risk of long-term adverse health effects. We comprehensively reviewed cases of somatic diseases that required a hospital contact in survivors of osteosarcoma and Ewing sarcoma. In a population-based cohort study, 620 five-year survivors of osteosarcoma (n = 440) or Ewing sarcoma (n = 180), diagnosed before the age of 20 years in Denmark, Finla

Two Gettier cases are described in detail and it is shown how they unfold in terms of reflective and reflexive desiderata. It is argued that the Gettier problem does not pose a problem for conceptions of knowledge as long as we are consistent in how we understand justification and knowledge. It is only by reading the cases with a reflective understanding of justification but a reflexive understand

Design criteria for tissue-engineered materials in regenerative medicine include robust biological effectiveness, off-the-shelf availability, and scalable manufacturing under standardized conditions. For bone repair, existing strategies rely on primary autologous cells, associated with unpredictable performance, limited availability and complex logistic. Here, a conceptual shift based on the manuf

Objective: We studied a cohort of patients with nonsyndromic complete atrioventricular septal defect with and without concomitant complex cardiac anatomy and compared the outcomes after surgical repair. Methods: Between 1993 and 2018, 62 nonsyndromic patients underwent complete atrioventricular septal defect repair. Sixteen patients (26%) had complex complete atrioventricular septal defect with va

Most pyrolysis reactors require small sizes of biomass particles to achieve high‐quality products. Moreover, understanding the usefulness of high‐pressure systems in pyrolysis is important, given the operational challenges they exhibit specific to various biomass materials. To actualize these aspects, the authors first checked previous reviews involving pyrolysis on different biomass and different

Background: Severe eosinophilic asthma is a high-burden disease. Mepolizumab has been effective in several randomized clinical trials. However, such success might not be applicable to patients treated in usual clinical practice. The objectives of this article are to evaluate the efficacy of mepolizumab in severe uncontrolled eosinophilic asthma under usual clinical practice, and to determine chara

Conservation organizations are increasingly applying adaptive capacity assessments in response to escalating climate change impacts. These assessments are essential to identify climate risks to ecosystems, prioritize management interventions, maximize the effectiveness of conservation actions, and ensure conservation resources are allocated appropriately. Despite an extensive literature on the top

We have learnt several lessons from the Nordic countries. The management of natural resources can explain a notable part of their success, but it would be naive to extract from the chapters in this book a recipe laying out a path to success for countries with abundant natural resources.

Climate change will have a progressively increasing impact on environmental degradation and environmentally dependent socio-economic systems with potential to cause substantial population displacement. The key concerns in Less Developed Countries (LDCs) will include serious threats to food security and health, considerable economic decline, inundation of coastal areas, and degradation of land and

Addictive disorders are characterized by cognitive, behavioral, and neurological impairments caused by dysregulations of brain structure that can extend well beyond early withdrawal in the months and years of recovery. The present study aimed to examine the efficacy of neurofeedback rehabilitation on anxiety in methamphetamine abusers. The sample consisted of 14 male methamphetamine drug addicts w

Recurrent pregnancy loss (RPL), defined as three or more consecutive miscarriages, is hypothesized to share some of the same pathogenic factors as placenta-associated disorders. It has been hypothesized that a defect implantation causes pregnancy loss, while a partially impaired implantation may lead to late pregnancy complications. The aim of this retrospective register-based cohort study was to

In the 1930s and 1940s, Ukraine experienced political violence on an unprecedented scale. Political violence by the Soviet government and the German occupation authorities resulted in the death of millions, through starvation, deportations, and massacres, and left wounds which still have not fully healed. Independently of the Soviets and Nazis, mass political violence was carried out also by the O