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PURPOSE: Recent studies demonstrated reduced cardiovascular (CV) risk with gonadotropin-releasing hormone (GnRH) antagonist, yet the underlying mechanism remains undetermined. The objective of this study was to examine longitudinal changes over time in established CV related proteins among men treated with GnRH agonists vs GnRH antagonist. MATERIALS AND METHODS: We performed a proteomics analysis

Climate during the Last Interglacial period (LIG, Marine Isotope Stage 5e) was on average warmer than the present, with a higher global sea level but also more unstable conditions. Today, the Baltic Sea interacts strongly with conditions in the North Atlantic region, and this interaction was likely even stronger during the LIG. We here present a reconstruction of seawater conditions during the LIG

The human forebrain has expanded in size and complexity compared to chimpanzees despite limited changes in protein-coding genes, suggesting that gene expression regulation is an important driver of brain evolution. Here, we identify a KRAB-ZFP transcription factor, ZNF558, that is expressed in human but not chimpanzee forebrain neural progenitor cells. ZNF558 evolved as a suppressor of LINE-1 tran

Introduction: Patients with low rectal cancer are at risk for lateral lymph node metastasis (LLNM). Neoadjuvant chemoradiotherapy (CRT) is used to eradicate LLNM in the West, whereas in Japan the addition of lateral lymph node dissection (LLND) to total mesorectal excision (TME) is performed. A systematic review was conducted to assess incidence, location, risk factors and diagnosis of LLNM and la

Is China beating the US and EU through its pragmatic approach towards cooperation under the “Belt and Road” Initiative (“一带一路”倡议) (BRI)? Despite the advent of the US’ “Build Back Better World” (B3W) and the EU’s “Connecting Europe Globally” (CEG), evidence from Sri Lanka suggests that some countries still look to China for support due to the ‘no-strings-attached’ nature of its investments. The sta

En essä om Livius och kriget mot Hannibal utifrån Karin Westin Tikkanens översättning Hannibalkriget (Appell förlag), bok 21 och 22 av Livius historiska verk Ab urbe condita.

This thesis aims to acquire deep knowledge on turbulent premixed combustion at high Karlovitz (Ka) number conditions with the help of laser-based diagnostic measurements.Considering that ammonia (NH3), as a carbon-free energy carrier, is a promising candidate for replacing conventional fossil fuels in the future, all the investigations in this work were carried out on ammonia/air premixed flames.

Populationstrender för fåglar på havsstrandängar i sju län analyserades för perioden 1988–2018. För 27 arter där en trend kunde beräknas för hela perioden var bestånden minskande för 13 arter, ökande för 8 arter och för 6 arter fanns ingen säker förändring. Vid analys för perioden 2003–2018 kunde trender beräknas för 38 arter och bestånden var minskande för 18 arter, ökande för 10 arter och oförän

PURPOSE: We performed an exploratory analysis of prostate cancer-related pain and fatigue on health-related quality of life in patients with metastatic castration-sensitive prostate cancer receiving apalutamide (240 mg/day) or placebo, with continuous androgen deprivation therapy (ADT), in the phase 3, randomized, double-blind, placebo controlled TITAN trial (NCT02489318). MATERIALS AND METHODS: P

Agriculture in sub-Saharan Africa is undergoing rapid transformation involving major changes in farmland ownership and farm scales from small to medium farms, with the widespread use of mechanisation and agro-inputs. Generally, households are increasing their farm sizes while others are dropping out of agriculture as the non-farm economy grows in both rural and urban areas. This study examined the

I denna rapport redovisas populationstrender för 228 svenska fågelarter för olika långa tidsperioder. Vi visar också korttidstrender för 12 arter av större däggdjur. Fåglarna har räknats höst, vinter, vår och sommar enligt strikt standardiserade metoder. Sommar- respektive vinterpunktrutter har räknats sedan 1975, i huvudsak i södra Sverige. Standardrutterna räknas också på sommaren (sedan1996) meWe present the results of the Swedish Bird Survey, run by the Department of Biology, Lund University, as a part of the National Monitoring Programme of the Swedish Environmental Protection Agency. The results for 2020 include data from: 564 winter point counts in 2019/2020 (45th winter), of which 274 were carried out during the Christmas/New Year count, 210 summer point count routes (46th year) an

BackgroundWith advancing age the brain becomes more sensitive to centrally acting drugs thus increasing the risk of cognitive side-effects. The Swedish National Board of Health and Welfare developed indicators to measure and follow quality in older people's drug therapy, one being “Potentially Inappropriate Medications risking Cognitive impairment (PIMcogn)”. Associations between anticholinergics

Cognitive semiotics is understood here to consist in the merger of the two great transdisciplinary endeavours (re)emerging in the middle of the last century, semiotics and cognitive science, the common core of which may consist in the phenomenological perspective, in both Husserl’s and Peirce’s sense of the term. We explore and revise Louis Prieto’s characterization of the semiotic sciences, traci

In Krisis, and in many of the preparatory papers for his last published work, Edmund Husserl repeatedly declares his allegiance to the Enlightenment, but, at the same time, always expresses his misgivings about its concrete purport. Like Horkheimer and Adorno, but for somewhat different reasons, he thus succumbs to what Ferrone has termed the philosopher’s conception of the Enlightenment, as opposIn Krisis, and in many of the preparatory papers for his last published work, Edmund Husserl repeatedly declares his allegiance to the Enlightenment, but, at the same time, always expresses his misgivings about its concrete purport. Like Horkheimer and Adorno, but for somewhat different reasons, he thus succumbs to what Ferrone has termed the philosopher’s conception of the Enlightenment, as oppos

In 1981 appeared my first published paper, with the title, “A plea for integral linguistics”,which summarized the epistemological stance of my 1978 doctoral dissertation. In a lecture given in Bucharest, published only in 2004, Coseriu said that he very belatedly, in 1981, applied the term “integral linguistics” to his conception of linguistics. There is an enormous difference between a young scho

Emily Skop, Martina Angela Caretta, Caroline Faria and Jessi L. Smith offer other scholars engaged in research collaborations a pledge to help foster and sustain more equitable relationships.

As the COVID-19 pandemic continues to affect societies across the world, the ongoing economic and social disruptions are likely to present fundamental challenges for current and future biodiversity conservation. We review the literature for outcomes of past major societal, political, economic and zoonotic perturbations on biodiversity conservation, and demonstrate the complex implications of pertu

In this paper we target the color transfer estimation problem, when we have pixel-to-pixel correspondences. We present a feature-based method, that robustly fits color transforms to data containing gross outliers. Our solution is based on an optimal inlier maximization algorithm that maximizes the number of inliers in polynomial time. We introduce a simple feature detector and descriptor based on

In this paper we present a unified formulation for a large class of relative pose problems with radial distortion and varying calibration. For minimal cases, we show that one can eliminate the number of parameters down to one to three. The relative pose can then be expressed using varying calibration constraints on the fundamental matrix, with entries that are polynomial in the parameters. We can